Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations

Volume: 8, Issue: 1
Published: Apr 21, 2017
Abstract
Several studies using genome-wide molecular techniques have reported various degrees of genetic heterogeneity between primary tumours and their distant metastases. However, it has been difficult to discern patterns of dissemination owing to the limited number of patients and available metastases. Here, we use phylogenetic techniques on data generated using whole-exome sequencing and copy number profiling of primary and multiple-matched...
Paper Details
Title
Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations
Published Date
Apr 21, 2017
Volume
8
Issue
1
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