Original paper
Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation
Abstract
Tissue factor pathway inhibitor (TFPI), the main inhibitor of initiation of coagulation, exerts an important anticoagulant role through the factor Xa (FXa)-dependent inhibition of tissue factor/factor VIIa. Protein S is a TFPI cofactor, enhancing the efficiency of FXa inhibition. TFPI can also inhibit prothrombinase assembly by directly interacting with coagulation factor V (FV), which has been activated by FXa. Because full-length TFPI...
Paper Details
Title
Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation
Published Date
Jun 1, 2017
Volume
292
Issue
22
Pages
9335 - 9344
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Notes
History