Journal of Biological Chemistry
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#1Yuening Liu (WSU: Washington State University)H-Index: 4
#2Jingrui Chen (WSU: Washington State University)H-Index: 3
Last. Zhaokang Cheng (WSU: Washington State University)H-Index: 14
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Reperfusion therapy, the standard treatment for acute myocardial infarction, can trigger necrotic death of cardiomyocytes and provoke ischemia/reperfusion (I/R) injury. However, signaling pathways that regulate cardiomyocyte necrosis remain largely unknown. Our recent genome-wide RNAi screen has identified a potential necrosis suppressor gene PRKAR1A, which encodes PKA regulatory subunit 1α (R1α). R1α is primarily known for regulating PKA activity by sequestering PKA catalytic subunits in the ab...
#1Whitney Kilu (Goethe University Frankfurt)H-Index: 3
#2Daniel Merk (Goethe University Frankfurt)H-Index: 18
Last. Jan Heering (Fraunhofer Society)H-Index: 10
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Nuclear receptors (NRs) activate transcription of target genes in response to binding of ligands to their ligand binding domains (LBDs). Typically, in vitro assays use either gene expression or the recruitment of coactivators to the isolated LBD of the NR of interest to measure NR activation. However, this approach ignores that NRs function as homo- as well as heterodimers, and that the LBD harbors the main dimerization interface. Cofactor recruitment is thereby interconnected with oligomerizati...
#1John P. Evans (OSU: Ohio State University)H-Index: 3
#2Shan-Lu Liu (OSU: Ohio State University)H-Index: 27
The zoonotic transmission of highly pathogenic coronaviruses into the human population is a pressing concern highlighted by the ongoing SARS-CoV-2 pandemic. Recent work has helped to illuminate much about the mechanisms of SARS-CoV-2 entry into the cell, which determines host- and tissue-specific tropism, pathogenicity, and zoonotic transmission. Here we discuss current findings on the factors governing SARS-CoV-2 entry. We first reviewed key features of the viral spike protein (S) mediating fus...
#1Sayantani Goswami (RU: Rutgers University)H-Index: 1
#2Iyshwarya Balasubramanian (RU: Rutgers University)H-Index: 4
Last. Nan Gao (RU: Rutgers University)H-Index: 31
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Within the intestinal epithelium, regulation of intracellular protein and vesicular trafficking is of utmost importance for barrier maintenance, immune responses, and tissue polarity. RAB11A is a small GTPase that mediates the anterograde transport of protein cargos to the plasma membrane. Loss of RAB11A-dependent trafficking in mature intestinal epithelial cells (IECs) results in increased epithelial proliferation and nuclear accumulation of Yes-Associated Protein (YAP), a key Hippo-signaling t...
#1Ekaterina S. Marakasova (CBER: Center for Biologics Evaluation and Research)H-Index: 4
#2Philip Olivares (CBER: Center for Biologics Evaluation and Research)
Last. Andrey G. Sarafanov (CBER: Center for Biologics Evaluation and Research)H-Index: 7
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The low-density lipoprotein receptor (LDLR) family of receptors are cell-surface receptors that internalize numerous ligands and play crucial role in various processes, such as lipoprotein metabolism, hemostasis, fetal development, etc. Previously, receptor-associated protein (RAP) was described as a molecular chaperone for LDLR-related protein 1 (LRP1), a prominent member of the LDLR family. We aimed to verify this role of RAP for LRP1 and two other LDLR family receptors, LDLR and vLDLR, and to...
#1Yan Li (NWAFU: Northwest A&F University)H-Index: 1
#2Yujia Huang (NWAFU: Northwest A&F University)
Last. Xiayan Liu (NWAFU: Northwest A&F University)H-Index: 14
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The dynamic responses of microtubules (MTs) to internal and external signals are modulated by a plethora of microtubule associated proteins (MAPs). In higher plants, many plant-specific MAPs have emerged during evolution as advantageous to their sessile lifestyle. Some members of the IQ67 domain (IQD) protein family have been shown to be plant-specific MAPs. However, the mechanisms of interaction between IQD proteins and MTs remain elusive. Here we demonstrate that the Domain of Unknown Function...
#1Ao Zhang (UGA: University of Georgia)H-Index: 1
#2Aarya Venkat (UGA: University of Georgia)H-Index: 3
Last. Robert S. Haltiwanger (UGA: University of Georgia)H-Index: 64
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Peters Plus Syndrome (PTRPLS OMIM #261540) is a severe congenital disorder of glycosylation where patients have multiple structural anomalies, including Peters anomaly of the eye (anterior segment dysgenesis), disproportionate short stature, brachydactyly, dysmorphic facial features, developmental delay, and variable additional abnormalities. PTRPLS patients and some Peters Plus-like (PTRPLS-like) patients, who only have a subset of PTRPLS phenotypes, have mutations in the gene encoding β1,3-glu...
#1Elena Pires (CSU: Colorado State University)H-Index: 1
#2Neelam Sharma (CSU: Colorado State University)H-Index: 18
Last. Claudia Wiese (CSU: Colorado State University)H-Index: 19
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Abstarct RAD51 Associated Protein 1 (RAD51AP1) is a key protein in the homologous recombination (HR) DNA repair pathway. Loss of RAD51AP1 leads to defective HR, genome instability, and telomere erosion. RAD51AP1 physically interacts with the RAD51 recombinase and promotes RAD51-mediated capture of donor DNA, synaptic complex assembly, and displacement-loop formation when tested with nucleosome-free DNA substrates. In cells, however, DNA is packaged into chromatin, posing an additional barrier to...
#1Thomas A. Bunch (UA: University of Arizona)H-Index: 19
#2Piyali Guhathakurta (UMN: University of Minnesota)H-Index: 5
Last. Brett A. Colson (UA: University of Arizona)H-Index: 12
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Abstract Cardiac myosin-binding protein C (cMyBP-C) interacts with actin and myosin to modulate cardiac muscle contractility. These interactions are disfavored by cMyBP-C phosphorylation. Heart failure patients often display decreased cMyBP-C phosphorylation, and phosphorylation in model systems has been shown to be cardioprotective against heart failure. Therefore, cMyBP-C is a potential target for heart failure drugs that mimic phosphorylation or perturb its interactions with actin/myosin. Her...
#1Olga Bocharova (UMB: University of Maryland, Baltimore)
#2Narayan P. Pandit (UMB: University of Maryland, Baltimore)
Last. Ilia V. Baskakov (UMB: University of Maryland, Baltimore)H-Index: 52
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Abstract Alzheimer's disease (AD) is a devastating fatal neurodegenerative disease. An alternative to the amyloid cascade hypothesis is that a viral infection is key to the etiology of late-onset AD, with β-amyloid (Aβ) peptides playing a protective role. In the current study, young 5XFAD mice that overexpress mutant human amyloid precursor protein with the Swedish, Florida, and London familial AD mutations were infected with one of two strains of herpes simplex virus 1 (HSV-1), 17syn+ and McKra...
Top fields of study
Molecular biology
Cell biology