Journal of Biological Chemistry
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#1Sarah G. Whaley (St. Jude Children's Research Hospital)H-Index: 2
#2Christopher D. Radka (St. Jude Children's Research Hospital)H-Index: 4
Last. Charles O. Rock (St. Jude Children's Research Hospital)H-Index: 93
view all 5 authors...
Abstract null null Bacterial fatty acid synthesis (FASII) in Escherichia coli is initiated by the condensation of an acetyl-CoA with a malonyl-acyl carrier protein (ACP) by the β-ketoacyl-ACP synthase III enzyme, FabH. E. coli ΔfabH knockout strains are viable due to the yiiD gene that allows FabH-independent FASII initiation. However, the molecular function of the yiiD gene product is not known. Here, we show the yiiD gene product is a null m alonyl- A CP null d ecarboxylase (MadA). MadA has tw...
#1Richard L. Cate (BU: Boston University)H-Index: 6
#2Nathalie di Clemente (University of Paris)H-Index: 28
Last. Adrian Whitty (BU: Boston University)H-Index: 39
view all 6 authors...
Noncovalent complexes of TGF-β family growth/differentiation factors with their prodomains are classified as latent or active, depending on whether the complexes can bind their respective receptors. For the anti-Mullerian hormone (AMH), the hormone/prodomain complex is active, and the prodomain is displaced upon binding to its type II receptor, AMHR2, on the cell surface. However, the mechanism by which this displacement occurs is unclear. Here, we used ELISA assays to measure the dependence of ...
#1Makoto Araki (Meiji Pharmaceutical University)H-Index: 6
#2Kaho Yoshimoto (Meiji Pharmaceutical University)
Last. Kenji Kontani (Meiji Pharmaceutical University)H-Index: 32
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Small GTPases cycle between an inactive GDP-bound and an active GTP-bound state to control various cellular events, such as cell proliferation, cytoskeleton organization, and membrane trafficking. Clarifying the guanine nucleotide-bound states of small GTPases is vital for understanding the regulation of small GTPase functions and the subsequent cellular responses. Although several methods have been developed to analyze small GTPase activities, our knowledge of the activities for many small GTPa...
#1Michael P. Young (Thomas Jefferson University)H-Index: 2
#2Zachary T. Schug (The Wistar Institute)H-Index: 21
Last. Suresh K. Joseph (Thomas Jefferson University)H-Index: 45
view all 7 authors...
Calcium signaling is essential for regulating many biological processes. Endoplasmic reticulum (ER) inositol trisphosphate receptors (IP3R) and the mitochondrial Ca2+ uniporter (MCU) are key proteins that regulate intracellular Ca2+ concentration. Mitochondrial Ca2+ accumulation activates Ca2+-sensitive dehydrogenases of the tricarboxylic acid (TCA) cycle that maintain the biosynthetic and bioenergetics needs of both normal and cancer cells. However, the interplay between calcium signaling and m...
#1Roshan Kumar (UM: University of Michigan–Ann Arbor)H-Index: 3
#2Aaron P. Landry (UM: University of Michigan–Ann Arbor)H-Index: 14
Last. Ruma Banerjee (UM: University of Michigan–Ann Arbor)H-Index: 86
view all 9 authors...
The dual roles of H2S as an endogenously synthesized respiratory substrate and as a toxin, raise questions as to how it is cleared when the electron transport chain is inhibited. Sulfide quinone oxidoreductase (SQOR) catalyzes the first step in the mitochondrial H2S oxidation pathway, using CoQ as an electron acceptor, and connects to the electron transport chain at the level of complex III. We have discovered that at high H2S concentrations, which are known to inhibit complex IV, a new redox cy...
#1Aswathy Chandran (Purdue University West Lafayette)H-Index: 1
#2Jean-Christophe Rochet (Purdue University West Lafayette)H-Index: 28
Small-molecule modulators of autophagy have been widely investigated as potential therapies for neurodegenerative diseases. In a recent issue of JBC, Safren et al. described a novel assay that uses a photoconvertible fusion protein to identify compounds that alter autophagic flux. Autophagy inducers identified using this assay were found to either alleviate or exacerbate neurotoxicity in different cellular models of amyotrophic lateral sclerosis, challenging the notion that autophagy stimulation...
#1Wijnand J C van der Velden (UCPH: University of Copenhagen)H-Index: 5
#2Peter Lindquist (UCPH: University of Copenhagen)H-Index: 1
Last. Mette M. Rosenkilde (UCPH: University of Copenhagen)H-Index: 55
view all 8 authors...
Naturally occurring missense variants of G protein-coupled receptors (GPCRs) with loss-of-function have been linked to metabolic disease in case studies and in animal experiments. The glucagon receptor, one such GPCR, is involved in maintaining blood glucose and amino acid homeostasis; however, loss-of-function mutations of this receptor have not been systematically characterized. Here, we observed fewer glucagon receptor missense variants than expected, as well as lower allele diversity and few...
#1Austin M. Reilly (IU: Indiana University)H-Index: 7
#2Shijun Yan (IU: Indiana University)H-Index: 15
Last. Hongxia RenH-Index: 9
view all 14 authors...
Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4 (GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an insulin-resistant mouse model with human GLUT4 promoter-driven insulin receptor knockout (GIRKO) in muscle, adipose, and neuronal subpopulations. However, the rate of diabetes in GIRKO mice remained low prior to 6 months of age on normal chow diet (NCD), suggesting that additional factors/mechanisms are responsible for a...
#1Stephanie M. Soohoo (GUMC: Georgetown University Medical Center)H-Index: 1
#2Purushottam Tiwari (GUMC: Georgetown University Medical Center)H-Index: 9
Last. Tinatin I. Brelidze (GUMC: Georgetown University Medical Center)H-Index: 10
view all 4 authors...
Human ether-a-go-go-related gene (hERG) channels are key regulators of cardiac repolarization, neuronal excitability, and tumorigenesis. hERG channels contain N-terminal Per-Arnt-Sim (PAS) and C-terminal cyclic nucleotide-binding homology (CNBH) domains with many long-QT syndrome (LQTS)-causing mutations located at the interface between these domains. Despite the importance of PAS/CNBH domain interactions, little is known about their affinity. Here, we used the surface plasmon resonance (SPR) te...
#1Christopher Gisriel (Yale University)H-Index: 7
#2Gaozhong Shen (PSU: Pennsylvania State University)H-Index: 41
Last. Donald A. Bryant (PSU: Pennsylvania State University)H-Index: 95
view all 13 authors...
Abstract null null Far-red light (FRL) photoacclimation (FaRLiP) in cyanobacteria provides a selective growth advantage for some terrestrial cyanobacteria by expanding the range of photosynthetically active radiation to include far-red/near-infrared light (700 to 800 nm). During this photoacclimation process, photosystem II (PSII), the water:plastoquinone photooxidoreductase involved in oxygenic photosynthesis, is modified. The resulting FRL-PSII is comprised of FRL-specific core subunits and bi...
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