Generalizability of findings from randomized controlled trials: application to the National Institute of Drug Abuse Clinical Trials Network

Aims To compare randomized controlled trial (RCT) sample treatment effects with the population effects of substance use disorder (SUD) treatment. Design Statistical weighting was used to re-compute the effects from 10 RCTs such that the participants in the trials had characteristics that resembled those of patients in the target populations. Settings Multi-site RCTs and usual SUD treatment settings in the United States. Participants A total of...