Randomized phase II study of S-1 and concurrent radiotherapy with versus without induction chemotherapy of gemcitabine for locally advanced pancreatic cancer (LAPC): Final analysis of JCOG1106

JCOG1106 is a phase II trial to evaluate the efficacy and safety of chemoradiotherapy (CRT) with and without induction chemotherapy (CT) to determine which is more promising CRT regimen for LAPC. Primary endpoint was overall survival (OS). 102 patients (pts) were randomized to CRT (Arm A) or induction CT followed by CRT (Arm B), and 100 pts (Arm A/B n = 51/49) were eligible. In the primary analysis performed 1 year after completion of...