Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis

Highlights•CLCb and Dyn1 contribute to adaptive clathrin-mediated endocytosis in cancer cells•CLCb modulates dynamin-1 via an APPL1/Akt/GSK3β signaling circuit•Upregulation of CLCb alters EGFR trafficking dependent on dynamin-1•Upregulation of CLCb increases tumor cell migration and metastasisSummarySignaling receptors are internalized and regulated by clathrin-mediated endocytosis (CME). Two clathrin light chain isoforms, CLCa and CLCb, are...