Developmental Cell
Papers 5,131
1 page of 514 pages (5,131 results)
#1Nathan M. Willy (OSU: The Ohio State University)H-Index: 4
#2Joshua P. Ferguson (OSU: The Ohio State University)H-Index: 4
Last. Comert Kural (OSU: The Ohio State University)H-Index: 16
view all 16 authors...
Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation on the cell surface, which is the primary function of the endocytosis machinery. Using super-resolved live cell fluorescence imaging, we demonstrate that curvature generation by individual clathrin-coated pits can be detected in real time within cultured cells and tissues of developing organisms. Our analyses demonstrate that the footprint of clathrin coats increases monotonically during the formation of p...
#1Ting Wang (Yale University)
#2Zheng Wang (Qingdao University)
Last. Fabio Rinaldo Santori (Yale University)H-Index: 1
view all 24 authors...
Summary null null Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for development of the nervous system, heart, v...
#1Onur Sen (University of Warwick)H-Index: 5
#2Jonathan U. Harrison (University of Warwick)H-Index: 4
Last. Andrew D. McAinsh (University Hospital Coventry)H-Index: 33
view all 4 authors...
Summary null Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of cancer and linked to cancer genome evolution. Errors can manifest as "lagging chromosomes" in anaphase, although their mechanistic origins and likelihood of correction are incompletely understood. Here, we combine lattice light-sheet microscopy, endogenous protein labeling, and computational analysis to define the life history of >104 kinetochores. By defining the "laziness" of kinetochores in anap...
#1Shefali Krishna (Salk Institute for Biological Studies)H-Index: 1
#2Rafael Arrojo E. Drigo (UCSD: University of California, San Diego)H-Index: 1
Last. Martin W. Hetzer (Salk Institute for Biological Studies)H-Index: 58
view all 6 authors...
In order to combat molecular damage, most cellular proteins undergo rapid turnover. We have previously identified large nuclear protein assemblies that can persist for years in post-mitotic tissues and are subject to age-related decline. Here, we report that mitochondria can be long lived in the mouse brain and reveal that specific mitochondrial proteins have half-lives longer than the average proteome. These mitochondrial long-lived proteins (mitoLLPs) are core components of the electron transp...
#1Ethan C. Strayer (Yale University)
#2Valerie A. Tornini (Yale University)H-Index: 10
Last. Antonio J. Giraldez (Yale University)H-Index: 37
view all 3 authors...
A cell's identity is commonly regarded as its transcriptomic profile. In this issue of Developmental Cell, Fujii et al. (2021) show that a global translation factor subunit acts differentially on transcripts to modulate morphogen signaling levels, revealing a global mechanism of transcript-specific translational control in development.
#1Lanlan Jia (SCU: Sichuan University)H-Index: 1
#2Maoxing Liao (SCU: Sichuan University)
Last. Mina Chen (SCU: Sichuan University)H-Index: 8
view all 11 authors...
The metabolic coupling of Schwann cells (SCs) and peripheral axons is poorly understood. Few molecules in SCs are known to regulate axon stability. Using SC-specific Rheb knockout mice, we demonstrate that Rheb-regulated mitochondrial pyruvate metabolism is critical for SC-mediated non-cell-autonomous regulation of peripheral axon stability. Rheb knockout suppresses pyruvate dehydrogenase (PDH) activity (independently of mTORC1) and shifts pyruvate metabolism toward lactate production in SCs. Th...
#1Daniel Andergassen (TUM: Technical University of Munich)H-Index: 3
#2Zachary D. Smith (Yale University)H-Index: 25
Last. Alexander MeissnerH-Index: 90
view all 5 authors...
Genomic imprinting and X chromosome inactivation (XCI) require epigenetic mechanisms to encode allele-specific expression, but how these specific tasks are accomplished at single loci or across chromosomal scales remains incompletely understood. Here, we systematically disrupt essential epigenetic pathways within polymorphic embryos in order to examine canonical and non-canonical genomic imprinting as well as XCI. We find that DNA methylation and Polycomb group repressors are indispensable for a...
#1Annmary Paul Erinjeri (UCL: University College London)
#2John Labbadia (UCL: University College London)H-Index: 2
The significance of mitochondrial long-lived proteins (mitoLLPs) to tissue health has remained mysterious for over a decade. In this issue of Developmental Cell, Krishna et al. demonstrate that mitochondrial lifetimes are highly heterogeneous and that mitoLLPs promote respiratory capacity by facilitating supercomplex assembly within the electron transport chain.
#1Cecilia Rodriguez-Furlan (UCR: University of California, Riverside)H-Index: 10
#2Jaimie M. Van Norman (UCR: University of California, Riverside)H-Index: 16
How protein dynamics contribute to developmental processes is a critical biological question. In this issue of Developmental Cell, Ju et al. show that subcellular localization of NORTIA in the female gametophyte is required for pollen reception. NORTIA redistribution boosts cues that drive pollen tube bursting, thus promoting male gamete release and fertilization.
#1Kotaro Fujii (UF: University of Florida)H-Index: 7
#2Olena Zhulyn (SU: Stanford University)H-Index: 6
Last. Maria Barna (SU: Stanford University)H-Index: 30
view all 7 authors...
Summary null null Although gene expression is tightly regulated during embryonic development, the impact of translational control has received less experimental attention. Here, we find that eukaryotic translation initiation factor-3 (eIF3) is required for Shh-mediated tissue patterning. Analysis of loss-of-function eIF3 subunit c (Eif3c) mice reveal a unique sensitivity to the Shh receptor patched 1 (Ptch1) dosage. Genome-wide in vivo enhanced cross-linking immunoprecipitation sequence (eCLIP-s...
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