Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours

Published on Jan 1, 2017in Nature Reviews Neurology42.937
· DOI :10.1038/NRNEUROL.2016.185
Milan Makale21
Estimated H-index: 21
(UCSD: University of California, San Diego),
Carrie R. McDonald39
Estimated H-index: 39
(UCSD: University of California, San Diego)
+ 1 AuthorsSantosh Kesari69
Estimated H-index: 69
The majority of patients who receive radiotherapy for brain tumours go on to develop disability, but the pathophysiological mechanisms of radiation-associated cognitive decline remains poorly understood. Here, Makale and colleagues review animal model and patient data on the mechanisms of radiotherapy-associated CNS damage and posit that early damage — occurring before 6 months after irradiation — contributes to long-term cognitive disability.
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