Nature Reviews Neurology
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#1Maria Stamelou (University of Marburg)H-Index: 42
#2Gesine Respondek (MHH: Hannover Medical School)H-Index: 15
Last. Günter U. Höglinger (German Center for Neurodegenerative Diseases)H-Index: 57
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Tauopathies are classified according to whether tau deposits predominantly contain tau isoforms with three or four repeats of the microtubule-binding domain. Those in which four-repeat (4R) tau predominates are known as 4R-tauopathies, and include progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, globular glial tauopathies and conditions associated with specific MAPT mutations. In these diseases, 4R-tau deposits are found in various cell types and anatomical ...
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#1Jan D. Lünemann (WWU: University of Münster)H-Index: 4
A randomized, placebo-controlled trial has found the neonatal Fc receptor modulator efgartigimod to be an effective therapy for generalized myasthenia gravis. If a pending FDA application is approved, the treatment will be the first recombinant antibody-based therapy for selective IgG depletion, adding to a growing spectrum of treatment options for myasthenia gravis.
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The burden of epilepsy among forcibly displaced persons is thought to be high, and access to treatment is limited. In June 2021, the WHO Secretariat published a draft intersectoral action plan aimed at redressing the global epilepsy treatment gap, providing a valuable opportunity to improve epilepsy treatment for forcibly displaced persons.
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#1Meichen Yu (IU: Indiana University)H-Index: 9
#2Olaf SpornsH-Index: 102
Last. Andrew J. Saykin (IU: Indiana University)H-Index: 127
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#1Velda X. Han (Children's Hospital at Westmead)H-Index: 1
#1Velda X. Han (Children's Hospital at Westmead)H-Index: 1
Last. Russell C. Dale (Children's Hospital at Westmead)H-Index: 71
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Maternal health during pregnancy plays a major role in shaping health and disease risks in the offspring. The maternal immune activation hypothesis proposes that inflammatory perturbations in utero can affect fetal neurodevelopment, and evidence from human epidemiological studies supports an association between maternal inflammation during pregnancy and offspring neurodevelopmental disorders (NDDs). Diverse maternal inflammatory factors, including obesity, asthma, autoimmune disease, infection a...
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