Original paper

Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

Volume: 7, Issue: 1
Published: Jul 28, 2016
Abstract
Cancer stem cells (CSCs) have key roles in treatment resistance, tumour metastasis and relapse. Using colorectal cancer (CC) cell lines, patient-derived xenograft (PDX) tissues and patient tissues, here we report that CC CSCs, which resist chemoradiation, have higher SUMO activating enzyme (E1) and global SUMOylation levels than non-CSCs. Knockdown of SUMO E1 or SUMO conjugating enzyme (E2) inhibits CC CSC maintenance and self-renewal, while...
Paper Details
Title
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
Published Date
Jul 28, 2016
Volume
7
Issue
1
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