Understanding the role of the perivascular space in cerebral small vessel disease

Small vessel diseases (SVDs) are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35–36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20–25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor...