Cardiovascular Research
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#1Mitch KanterH-Index: 3
#2Siddhartha S. Angadi (UVA: University of Virginia)H-Index: 15
Last. Katherine A. Beals (UofU: University of Utah)H-Index: 12
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#1Tasnim Mohaissen (Jagiellonian University)H-Index: 3
#2Bartosz Proniewski (Jagiellonian University)H-Index: 9
Last. Marek Grosicki (Jagiellonian University)H-Index: 4
view all 18 authors...
AIMS Endothelial dysfunction (ED) and red blood cell distribution width (RDW) are both prognostic factors in heart failure (HF), but the relationship between them is not clear. In this study, we used a unique mouse model of chronic HF driven by cardiomyocyte-specific overexpression of activated Gαq protein (Tgαq*44 mice) to characterise the relationship between the development of peripheral ED and the occurrence of structural nanomechanical and biochemical changes in red blood cells (RBCs). METH...
#1Monika M Gladka (UvA: University of Amsterdam)
#2Vincent M. Christoffels (UvA: University of Amsterdam)H-Index: 70
Commentary on 'Single-cell measurement of higher-order 3D genome organization with scSPRITE.'
#1Gabriele Riccardi (University of Naples Federico II)H-Index: 67
#2Annalisa Giosuè (University of Naples Federico II)H-Index: 1
Last. Olga Vaccar (University of Naples Federico II)
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#2Christian BaumeierH-Index: 2
Last. Felicitas Escher (Humboldt University of Berlin)
view all 6 authors...
Infection of the heart muscle with cardiotropic viruses is one of the major etiologies of myocarditis and acute and chronic inflammatory cardiomyopathy (DCMi). However, viral myocarditis and subsequent dilated cardiomyopathy (DCM) is still a challenging disease to diagnose and to treat and is therefore a significant public health issue globally. Advances in clinical examination and thorough molecular genetic analysis of intramyocardial viruses and their activation status have incrementally impro...
#1Thomas Münzel (University of Mainz)H-Index: 132
#2Omar Hahad (University of Mainz)H-Index: 11
Last. Andreas Daiber (University of Mainz)H-Index: 72
view all 7 authors...
Noncommunicable diseases (NCDs) are fatal for more than 38 million people each year and are thus the main contributors to the global burden of disease accounting for 70% of mortality. The majority of these deaths are caused by cardiovascular disease. The risk of NCDs is strongly associated with exposure to environmental stressors such as pollutants in the air, noise exposure, artificial light at night and climate change, including heat extremes, desert storms and wildfires. In addition to the tr...
Aims null Remdesivir is a prodrug of an adenosine triphosphate analogue and is currently the only drug formally approved for the treatment of hospitalised COVID-19 patients. Nucleoside/nucleotide analogues have been shown to induce mitochondrial damage and cardiotoxicity, and this may be exacerbated by hypoxia, which frequently occurs in severe COVID-19 patients. Although there have been few reports of adverse cardiovascular events associated with remdesivir, clinical data are limited. Here, we ...
#1David Pereyra (Medical University of Vienna)H-Index: 9
#2Stefan Heber (Medical University of Vienna)H-Index: 7
Last. Fabian Fritsch (Medical University of Vienna)
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AIM: Anticoagulation was associated with improved survival of hospitalized COVID-19 patients in large-scale studies. Yet, the development of COVID-19 associated coagulopathy (CAC) and the mechanism responsible for improved survival of anticoagulated patients with COVID-19 remain largely elusive. This investigation aimed to explore the effects of anticoagulation and low molecular weight heparin (LMWH) in particular on patient outcome, CAC development, thromboinflammation, cell death, and viral pe...
#1Gabrielle Fredman (Albany Medical College)H-Index: 28
#2Katherine C. MacNamara (Albany Medical College)H-Index: 11
The resolution of inflammation (or inflammation-resolution) is an active and highly coordinated process. Inflammation-resolution is governed by several endogenous factors, and specialized pro-resolving mediators (SPMs) are one such class of molecules that have robust biological function. Non-resolving inflammation is associated with a variety of human diseases, including atherosclerosis. Moreover, non-resolving inflammation is a hallmark of aging, an inevitable process associated with increased ...
#1Anabela Bensimon-Brito (MPG: Max Planck Society)H-Index: 11
#2Giulia L. M. Boezio (MPG: Max Planck Society)H-Index: 3
view all 12 authors...
AIMS Mammalian models have been instrumental in investigating adult heart function and human disease. However, electrophysiological differences with human hearts and high costs motivate the need for non-mammalian models. The zebrafish is a well-established genetic model to study cardiovascular development and function; however, analysis of cardiovascular phenotypes in adult specimens is particularly challenging as they are opaque. METHODS AND RESULTS Here, we optimized and combined multiple imag...
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