Tumors metastatic to the orbit.

Published on Jan 1, 1988in Ophthalmic Plastic and Reconstructive Surgery1.331
· DOI :10.1097/00002341-198804020-00003
Carol L. Shields120
Estimated H-index: 120
(Wills Eye Institute),
Jerry A. Shields119
Estimated H-index: 119
Michael Peggs1
Estimated H-index: 1
A review of 35 consecutive cases of tumors metastatic to the orbit revealed that the primary tumor site was breast in 18 cases (51%), prostate in 6 cases (17%), lung in 2 cases (6%), gastrointestinal tract in 2 cases (6%), kidney in 1 case (3%), cutaneous melanoma in 1 case (3%), contralateral choroidal melanoma in 1 case (3%), and unknown in 4 cases (11%). The most common presenting signs and symptoms included diplopia with noncomitant strabismus, proptosis, and a palpable mass. In nine cases (26%), the orbital metastasis was detected in patients with no prior history of cancer. The average patient survival after the diagnosis of orbital metastasis was 13 months. Orbital metastasis from lung carcinoma carried the worst prognosis, with an average survival time of only 4 months. A summary of the clinical features of these 35 cases and a review of the literature on orbital metastatic disease will be presented.
📖 Papers frequently viewed together
230 Citations
202 Citations
521 Citations
Cited By92
#1Christopher P. Long (UCSD: University of California, San Diego)H-Index: 1
#2Tianlun Lu (UCSD: University of California, San Diego)
Last. Catherine Y. Liu (UCSD: University of California, San Diego)H-Index: 10
view all 7 authors...
An 84-year-old male with previously documented poor medical follow-up presented with progressive painless proptosis of the right eye. Right upper eyelid ptosis, limited motility, proptosis, and inferomedial displacement of the right globe were noted on the exam. Computed tomography (CT) imaging revealed a right retrobulbar extraconal heterogenous mass with ill-defined borders. Biopsy revealed a malignant adenocarcinoma with tumor markers suggestive of a colorectal primary. A rectal mass was iden...
Purpose To study the level of serum malondialdehyde (MDA), a biomarker of oxidative stress before and after chemotherapy in various ocular malignancies and to correlate its significance with clinicopathological parameters. Methods Thirty two histopathologically confirmed cases of primary ocular malignancies were included in this longitudinal cohort study. Detailed clinicopathological assessment was done. Analysis of serum MDA level in the patient before and after chemotherapy was measured and it...
5 CitationsSource
#1Abdullah Al-MujainiH-Index: 13
#2Rajendra P MauryaH-Index: 6
Last. Samer SinghH-Index: 20
view all 9 authors...
Objective This study aimed to evaluate the epidemiological and clinicopathological spectrum of ocular malignancies among patients presenting to a teaching hospital in Northern India. Methods A total of 246 histopathologically diagnosed patients with ocular malignancies were included in the study. Tumor type and size, primary origin and location of tumor, clinical staging, radiological findings, histopathological type, and treatment outcomes were assessed. Results Overall, males over 55 years of ...
A 62-year-old woman was referred for evaluation of a nonhealing epithelial defect of the left eye. Examination also revealed left upper lid ptosis, cicatricial lagophthalmos, and palpable lid masses. With probing, the patient admitted to recent history of lobular carcinoma and remote history of ductal carcinoma of the breast. Imaging showed abnormal tissue in the left extraconal orbit involving the lacrimal gland. After orbitotomy and biopsy of the mass, pathology specimens returned consistent w...
Ocular cancers are unique among the diseases of the eye, threatening both vision and life. In most cases, the diagnosis can be made utilizing a careful clinical history and specialized ocular examination. Eye cancer diagnosis relies heavily on imaging techniques such as high-frequency ultrasound, fluorescein angiography, anterior and posterior segment optical coherence tomography, computed tomography (CT), and magnetic resonance imaging (MRI). Once the diagnosis is established, treatment decisio...
20 CitationsSource
#1Alan A. McNab (University of Melbourne)H-Index: 42
A very large number of disorders affect the orbit, and many of these occur in the setting of systemic disease. This lecture covers selected aspects of orbital diseases with systemic associations in which the author has a particular clinical or research interest. Spontaneous orbital haemorrhage often occurs in the presence of bleeding diatheses. Thrombosis of orbital veins and ischaemic necrosis of orbital and ocular adnexal tissues occur with thrombophilic disorders, vasculitis, and certain bact...
8 CitationsSource
#1Edwina L EadeH-Index: 1
#2Thomas G HardyH-Index: 9
Last. Alan A. McNabH-Index: 42
view all 4 authors...
Aims To review the distribution of pathology in extraocular muscle (EOM) biopsies performed at a tertiary orbital centre, identify clinical and imaging features which are associated with benign or malignant diseases and indicate when biopsy is necessary for EOM enlargement. Methods Retrospective case series including 93 patients with EOM enlargement who underwent an EOM biopsy. Clinical, radiological and histopathological information was recorded from the medical records. Statistical analysis wa...
15 CitationsSource
#1Yeji Moon (UOU: University of Ulsan)
#2Sunah Kang (UOU: University of Ulsan)H-Index: 4
Last. Ho Seok Sa (UOU: University of Ulsan)
view all 4 authors...
#1Anna M. Rose (Moorfields Eye Hospital)H-Index: 12
#2Philip J. Luthert (UCL Institute of Ophthalmology)H-Index: 7
Last. Geoffrey E. Rose (UCL Institute of Ophthalmology)H-Index: 33
view all 5 authors...
BACKGROUND: Periocular melanoma is a rare but often deadly malignancy that arises in the uvea (commonest origin), conjunctiva or orbit (rarest primary site). Melanoma accounts for 5-10% of metastatic/secondary orbital malignancies, but only a tiny proportion of primary orbital neoplasia. Primary orbital melanoma (POM) is exceedingly rare, with approximately 50 cases reported to date. METHODS: All patients seen in the orbital unit at a tertiary referral hospital (1991-2016) with a biopsy-proven d...
8 CitationsSource
#1Anna M. Rose (Imperial College London)H-Index: 12
#2Sophie Cowen (Moorfields Eye Hospital)H-Index: 1
Last. Geoffrey E. Rose (UCL Institute of Ophthalmology)H-Index: 33
view all 5 authors...
Background: Ocular melanoma is a rare but often deadly malignancy that arises in the uvea, conjunctiva or orbit. Uveal melanoma is the most common type, with conjunctival melanoma being the second most frequently observed. Melanoma accounts for 5-10% of metastatic or secondary orbital malignancies, but only a minute proportion of primary orbital neoplasia. The aim of the study was to characterise the clinical presentation, treatment and prognosis in patients presenting with melanoma metastatic t...
10 CitationsSource