Abstract 5336: Targeting glioma growth and invasiveness by microRNA-1.

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. Median survival is about 14 months, even with the most effective regimen of surgery followed by radiation and chemotherapy. GBM is characterized by the hallmarks of cellular heterogeneity, rapid proliferation, angiogenesis and extensive invasion. The dual feature of high proliferation and infiltration constitutes the major challenge for glioma therapy, as even...