Jakub Godlewski
Polish Academy of Sciences
GeneCancerDownregulation and upregulationmicroRNAMolecular biologyTranscriptomeRegulation of gene expressionGene knockdownMesenchymal stem cellMicrovesiclesTumor microenvironmentGliomaBrain tumorStem cellEpigeneticsCancer researchGeneticsCancer stem cellCell growthSignal transductionTranscription factorBiologyCell biologyCancer cell
70Publications
29H-index
4,132Citations
Publications 67
Newest
#1Jakub GodlewskiH-Index: 29
#2Mohamed M. Farhath (Brigham and Women's Hospital)H-Index: 3
Last. Agnieszka BroniszH-Index: 25
view all 8 authors...
Oncolytic virus (OV) therapy, which is being tested in clinical trials for glioblastoma, targets cancer cells, while triggering immune cells. Yet OV sensitivity varies from patient to patient. As OV therapy is regarded as an anti-tumor vaccine, by making OV-infected cancer cells secrete immunogenic proteins, linking these proteins to transcriptome would provide a measuring tool to predict their sensitivity. A set of six patient-derived glioblastoma cells treated ex-vivo with herpes simplex virus...
Source
#1Agnieszka Bronisz (PAN: Polish Academy of Sciences)H-Index: 25
#2Arun K. Rooj (Brigham and Women's Hospital)H-Index: 12
Last. Jakub Godlewski (PAN: Polish Academy of Sciences)H-Index: 29
view all 9 authors...
The assortment of cellular microRNAs ("microRNAome") is a vital readout of cellular homeostasis, but the mechanisms that regulate the microRNAome are poorly understood. The microRNAome of glioblastoma is substantially down-regulated in comparison to the normal brain. Here, we find malfunction of the posttranscriptional maturation of the glioblastoma microRNAome and link it to aberrant nuclear localization of DICER, the major enzymatic complex responsible for microRNA maturation. Analysis of DICE...
8 CitationsSource
#1Kamil Krawczynski (Brigham and Women's Hospital)H-Index: 8
#2Jakub Godlewski (PAN: Polish Academy of Sciences)H-Index: 29
Last. Agnieszka Bronisz (PAN: Polish Academy of Sciences)H-Index: 25
view all 3 authors...
Rapid growth of brain tumors such as glioblastoma often results in oxygen deprivation and the emergence of hypoxic zones. In consequence, the enrichment of reactive oxygen species occurs, harming nonmalignant cells and leading them toward apoptotic cell death. However, cancer cells survive such exposure and thrive in a hypoxic environment. As the mechanisms responsible for such starkly different outcomes are not sufficiently explained, we aimed to explore what transcriptome rearrangements are us...
2 CitationsSource
#1Agnieszka Bronisz (Brigham and Women's Hospital)H-Index: 25
#2Elzbieta Salinska (PAN: Polish Academy of Sciences)H-Index: 16
Last. Jakub Godlewski (Brigham and Women's Hospital)H-Index: 29
view all 4 authors...
Malignant brain tumor—glioblastoma is not only difficult to treat but also hard to study and model. One of the reasons for these is their heterogeneity, i.e., individual tumors consisting of cancer cells that are unlike each other. Such diverse cells can thrive due to the simultaneous co-evolution of anatomic niches and adaption into zones with distorted homeostasis of oxygen. It dampens cytotoxic and immune therapies as the response depends on the cellular composition and its adaptation to hypo...
3 CitationsSource
#1Daisuke Ogawa (Brigham and Women's Hospital)H-Index: 8
#2Khairul Ansari (Brigham and Women's Hospital)H-Index: 1
Last. Jakub Godlewski (Brigham and Women's Hospital)H-Index: 29
view all 6 authors...
Malignant glioblastoma (GBM, glioma) is the most common and aggressive primary adult brain tumor. The prognosis of GBM patients remains poor, despite surgery, radiation and chemotherapy. The major obstacles for successful remedy are invasiveness and therapy resistance of GBM cells. Invasive glioma cells leave primary tumor core and infiltrate surrounding normal brain leading to inevitable recurrence, even after surgical resection, radiation and chemotherapy. Therapy resistance allowing for selec...
17 CitationsSource
#1Aizhen Xiao (UVA: University of Virginia)H-Index: 14
#2Breanna Brenneman (UVA: University of Virginia)H-Index: 4
Last. Benjamin PurowH-Index: 27
view all 13 authors...
// Aizhen Xiao 1 , Breanna Brenneman 1 , Desiree Floyd 1 , Laurey Comeau 2 , Kelsey Spurio 1 , Inan Olmez 1 , Jeongwu Lee 3 , Ichiro Nakano 4 , Jakub Godlewski 5 , Agnieszka Bronisz 5 , Noritaka Kagaya 6 , Kazuo Shin-ya 6 and Benjamin Purow 1 1 Departments of Neurology, University of Virginia, Charlottesville, VA 22908, USA 2 Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA 3 Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Ins...
15 CitationsSource
#1Jakub Godlewski (Brigham and Women's Hospital)H-Index: 29
#2Jacek Lenart (PAN: Polish Academy of Sciences)H-Index: 8
Last. Elzbieta Salinska (PAN: Polish Academy of Sciences)H-Index: 16
view all 3 authors...
The mammalian brain is made up of billions of neurons and supporting cells (glial cells), intricately connected. Molecular perturbations often lead to neurodegeneration by progressive loss of structure and malfunction of neurons, including their death. On the other side, a combination of genetic and cellular factors in glial cells, and less frequently in neurons, drive oncogenic transformation. In both situations, microenvironmental niches influence the progression of diseases and therapeutic re...
26 CitationsSource
#1Vivek Bhaskaran (Brigham and Women's Hospital)H-Index: 4
#2Michał Nowicki (Brigham and Women's Hospital)H-Index: 37
Last. Pierpaolo Peruzzi (Brigham and Women's Hospital)H-Index: 12
view all 16 authors...
MicroRNA deregulation is a consistent feature of glioblastoma, yet the biological effect of each single gene is generally modest, and therapeutically negligible. Here we describe a module of microRNAs, constituted by miR-124, miR-128 and miR-137, which are co-expressed during neuronal differentiation and simultaneously lost in gliomagenesis. Each one of these miRs targets several transcriptional regulators, including the oncogenic chromatin repressors EZH2, BMI1 and LSD1, which are functionally ...
49 CitationsSource
#1Inan Olmez (UVA: University of Virginia)H-Index: 6
#2Ying Zhang (UVA: University of Virginia)H-Index: 35
Last. Benjamin Purow (UVA: University of Virginia)H-Index: 27
view all 12 authors...
Glioblastoma (GBM) is the most common primary brain malignancy and carries an extremely poor prognosis. Recent molecular studies revealed the CDK4/6-Rb-E2F axis and receptor tyrosine kinase (RTK) signaling to be deregulated in most GBM, creating an opportunity to develop more effective therapies by targeting both pathways. Using a phospho-RTK protein array, we found that both c-Met and TrkA-B pathways were significantly activated upon CDK4/6 inhibition in GBM cells. We therefore investigated the...
26 CitationsSource
#1Franz Ricklefs (UHH: University of Hamburg)H-Index: 5
#2Quazim A. Alayo (Brigham and Women's Hospital)H-Index: 9
Last. E. Antonio Chiocca (Brigham and Women's Hospital)H-Index: 79
view all 29 authors...
Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1) leads to cancer immune evasion via inhibition of T cell function. One of the defining characteristics of glioblastoma, a universally fatal brain cancer, is its profound local and systemic immunosuppression. Glioblastoma has also been shown to generate extracellular vesicles (EVs), which may play an important role in tumor progression. We thus hypothesized that glioblastoma EVs may be important mediators of immu...
214 CitationsSource