Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes

Published on Nov 1, 2016in The Journal of Steroid Biochemistry and Molecular Biology4.294
· DOI :10.1016/J.JSBMB.2016.02.008
Cristina Palacios23
Estimated H-index: 23
(UPR: University of Puerto Rico),
Luz Maria De-Regil14
Estimated H-index: 14
(Micronutrient Initiative)
+ 1 AuthorsJuan Pablo Peña-Rosas25
Estimated H-index: 25
(WHO: World Health Organization)
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Abstract
Abstract Background Vitamin D deficiency is highly prevalent during pregnancy. It has been suggested that vitamin D supplementation during pregnancy may reduce the risk of adverse gestational outcomes. Objectives To update a previous meta-analysis on the effects of oral vitamin D supplementation (alone or in combination with other vitamins and minerals) during pregnancy on maternal 25(OH)D levels and risk of developing pre-eclampsia, gestational diabetes, preterm birth, impaired glucose tolerance, caesarean section, gestational hypertension and other adverse conditions. Methods We searched for randomized and quasi-randomized trials through the Cochrane Pregnancy and Childbirth Group’s Trials Register, the International Clinical Trials Registry Platform, the Networked Digital Library of Theses and Dissertations, and direct communications with relevant organizations. Assessments of inclusion criteria, extraction of data from included studies, and risk of bias’ assessments of the included studies were done independently by two review authors. Results We included 15 trials, excluded 27 trials and 23 trials are still ongoing/unpublished. Data from seven trials with 868 women suggest that pregnant women supplemented with vitamin D had significantly higher 25(OH)D levels compared to controls (mean difference: 54.7 nmol/L; 95% CI 36.6, 72.9). Two trials found a lower risk of preeclampsia (8.9% versus 15.5%; average risk ratio 0.52; 95% CI 0.25, 1.05) and two other trials found no difference in the risk of gestational diabetes with vitamin D supplementation. Also, three trials found that supplementation with vitamin D plus calcium reduced the risk of pre-eclampsia (5% versus 9%; average risk ratio 0.51; 95% CI 0.32, 0.80). Conclusion Supplementing pregnant women with vitamin D led to significantly higher levels of 25(OH)D at term compared to placebo/control but results were inconsistent. Vitamin D supplementation, with or without calcium, may be related to lower risk of preeclampsia but more studies are needed to confirm this.
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#1Luz Maria De-Regil (Micronutrient Initiative)H-Index: 18
#2Cristina Palacios (UPR: University of Puerto Rico)H-Index: 23
Last. Juan Pablo Peña-Rosas (WHO: World Health Organization)H-Index: 25
view all 4 authors...
BACKGROUND: Vitamin D deficiency or insufficiency is thought to be common among pregnant women. Vitamin D supplementation during pregnancy has been suggested as an intervention to protect against adverse pregnancy outcomes. OBJECTIVES: To examine whether oral supplements with vitamin D alone or in combination with calcium or other vitamins and minerals given to women during pregnancy can safely improve maternal and neonatal outcomes. METHODS: Search methods: We searched the Cochrane Pregnancy an...
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#1Aanchal Sablok (VMMC: Vardhman Mahavir Medical College)H-Index: 2
#2Aruna Batra (VMMC: Vardhman Mahavir Medical College)H-Index: 9
Last. Harish Chellani (VMMC: Vardhman Mahavir Medical College)H-Index: 14
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SummaryContext Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency. Objective (1) To find prevalence of vitamin D deficiency in pregnant women. (2) To evaluate the effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome. Design Randomized control trial from years 2010 to 2012. Setting Tertiary care cent...
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#1Masoud Etemadifar (IUMS: Isfahan University of Medical Sciences)H-Index: 26
#2Mohsen Janghorbani (IUMS: Isfahan University of Medical Sciences)H-Index: 40
Background: The aim of this preliminary study was to assess the safety and efficacy of high-dose oral vitamin D3 supplementation during pregnancy in women with multiple sclerosis (MS) in Isfahan, Iran. Methods: In a single center open-label randomized, controlled clinical Phase I/II pilot study, 15 pregnant women with confirmed MS with low serum 25-hydroxyvitamin D (25(OH)D) levels were randomly allocated to receive either 50,000 IU/week vitamin D3 or routine care from 12 to 16 weeks of gestatio...
#1Cristina Palacios (UPR: University of Puerto Rico)H-Index: 23
#2Lilliana González (UPR: University of Puerto Rico)H-Index: 4
Abstract Vitamin D deficiency is a major public health problem worldwide in all age groups, even in those residing in countries with low latitude, where it was generally assumed that UV radiation was adequate enough to prevent this deficiency, and in industrialized countries, where vitamin D fortification has been implemented now for years. However, most countries are still lacking data, particularly population representative data, with very limited information in infants, children, adolescents ...
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#1Constance Yap (USYD: University of Sydney)H-Index: 4
#2N. Wah Cheung (USYD: University of Sydney)H-Index: 29
Last. Mark McLean (University of Western Sydney)H-Index: 25
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OBJECTIVE Vitamin D deficiency in pregnancy is associated with an increased risk of gestational diabetes mellitus (GDM) and neonatal vitamin D deficiency. We conducted a double-blind, randomized controlled trial of low-dose (LD) versus high-dose (HD) vitamin D supplementation to investigate the effects of vitamin D supplementation on glucose metabolism during pregnancy. RESEARCH DESIGN AND METHODS Women with plasma 25-hydroxyvitamin D (25OHD) levels n = 89) or the recommended pregnancy dose of 4...
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#1Zatollah Asemi (KAUMS: Kashan University of Medical Sciences)H-Index: 57
#2Maryam Karamali (Arak University of Medical Sciences)H-Index: 21
Last. Ahmad Esmaillzadeh (IUMS: Isfahan University of Medical Sciences)H-Index: 76
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Aims/hypothesis This study was designed to assess the effects of calcium and vitamin D supplementation on the metabolic status of pregnant women with gestational diabetes mellitus (GDM).
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#1Augusto A. Litonjua (Harvard University)H-Index: 98
#2Nancy E. Lange (Harvard University)H-Index: 12
Last. Scott T. Weiss (Harvard University)H-Index: 171
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Abstract There is intense interest in the role of vitamin D in the development of asthma and allergies. However, studies differ on whether a higher vitamin D intake or status in pregnancy or at birth is protective against asthma and allergies. To address this uncertainty, the Vitamin D Antenatal Asthma Reduction Trial (VDAART) was developed. VDAART is a randomized, double-blind, placebo-controlled trial of vitamin D supplementation in pregnant women to determine whether prenatal supplementation ...
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#1Mahshid TaheriH-Index: 3
#2Azam BaheiraeiH-Index: 18
Last. Maryam Modarres (Tehran University of Medical Sciences)H-Index: 5
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Although vitamin D deficiency has been linked to potential complications in reproductive women, the recommended intake dosage of this vitamin in populations with high incidence of deficiency in preconception period has not been defined.The study investigated the effect of consuming a dosage of 2000 IU/day oral vitamin D for 105 days, on serum levels of this vitamin in reproductive women.229 women with 18-35 years old, who were confirmed to be vitamin D deficient (vitamin D < 75 nmol/L), were ran...
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#1Cameron C. GrantH-Index: 33
#2Alistair W. StewartH-Index: 64
Last. Carlos A. Camargo (Harvard University)H-Index: 148
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OBJECTIVE: To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥20 ng/mL during infancy. METHODS: A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks’ gestation to birth, and then their infants, from birth to age 6 months, were randomly assigned to 1 of 3 mother/infant groups: placebo/placebo, vitamin D 3 1000/400 IU, or vitamin D 3 2000/800 IU. Serum 25(OH)D and calcium concentrations were measur...
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#2Amir ZiaeeH-Index: 13
Last. Fatemeh Lalooha (QUMS: Qazvin University of Medical Sciences)H-Index: 4
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Abstract Objective To determine whether treatment of low serum vitamin D in pregnant women improves fetal growth indices. Study design In this open-label randomized clinical trial, 130 Iranian pregnant women (24–26 weeks of gestation) with vitamin D deficiency or insufficiency [25(OH)D 3 (50,000U) each week for 8 weeks. At delivery, maternal and cord blood 25(OH)D levels, maternal weight gain, neonatal length, neonatal weight and neonatal head circumference were compared between two groups. Seru...
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