The Journal of Steroid Biochemistry and Molecular Biology
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#1Roza Motavalli (Tabriz University of Medical Sciences)H-Index: 4
#2Taraneh Majidi (Tabriz University of Medical Sciences)
Last. Jalal Etemadi (Tabriz University of Medical Sciences)H-Index: 8
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Abstract null null The impacts of glucocorticoids (GCs) are mainly mediated by a nuclear receptor (GR) existing in almost every tissue. The GR regulates a wide range of physiological functions, including inflammation, cell metabolism, and differentiation playing a major role in cellular responses to GCs and stress. Therefore, the dysregulation or disruption of GR can cause deficiencies in the adaptation to stress and the preservation of homeostasis. The number of GR polymorphisms associated with...
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#1Jaya A. George (National Health Laboratory Service)H-Index: 13
#2Shane A. Norris (University of the Witwatersrand)H-Index: 62
Last. Nigel J. Crowther (National Health Laboratory Service)H-Index: 32
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BACKGROUND Vitamin D deficiency (VDD) has been associated with adverse maternal and foetal outcomes and is determined by measuring 25 hydroxyvitamin D (25(OH)D). The 25(OH)D is catabolized to 24, 25-(OH) 2D and the ratio of 25(OH) D to 24, 25-(OH)2D, the vitamin D metabolite ratio (VMR), is thought to be a superior marker of VDD, being elevated in such states. The aims of this study were to assess the longitudinal vitamin D status of pregnant women by measuring cholecalciferol, 25(OH)D, 24, 25-(...
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Abstract Vitamin D supplementation is widely recommended for animals and humans. However, its effects on extra-skeletal disorders have not been well proven. Our research aimed to analyse the effect of supplementation with standard and increased doses of vitamin D on the health status, biochemical and haematological parameters of blood as well as on the level of expression of genes metabolising vitamin D and the VDR gene in the kidney, liver, fat and brain of rats of different sexes. 36 Wistars r...
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#1Nasser M. Al-Daghri (KSU: King Saud University)H-Index: 58
#2Syed Danish Hussain (KSU: King Saud University)H-Index: 7
Last. Majed S. Alokail (KSU: King Saud University)H-Index: 30
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Abstract Objective Widespread vitamin D deficiency (serum 25-hydroxyvitamin D Study Design and Setting This cross-sectional series (N = 7360) were conducted in the central region of SA from 2008-2017. Participants of all ages were taken from multiple cohorts that included the Biomarker Screening in Riyadh (2008-2010; N = 1,460), the Osteoporosis Registry (2014-2017; N = 1,225), Gestational Diabetes Mellitus cohort (2014-2017, N = 281), Vitamin D School Project (2011 - 2017; N = 3,039) and Predia...
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Abstract null null Endogenous Cushing syndrome (CS) is an endocrine disorder marked by excess cortisol production rendering patients susceptible to visceral obesity, dyslipidemia, hypertension, osteoporosis and diabetes mellitus. Adrenal CS is characterized by autonomous production of cortisol from cortisol-producing adenomas (CPA) via adrenocorticotropic hormone-independent mechanisms. A limited number of studies have quantified the steroid profiles in sera from patients with CS. To understand ...
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#1Lijuan Ma (University of Bern)H-Index: 1
#2Thomas Andrieu (University of Bern)H-Index: 3
Last. Michael D. Mueller (University of Bern)H-Index: 37
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Endometriosis is a common, estrogen-dependent disease, in which endometrial tissue grows in the peritoneal cavity. These lesions often express low levels of progesterone receptors (PR), which potentially play an important role in the insufficient response to progestin treatment. Here, we uncover an interconnection between the downregulated PR expression and the epithelial-to-mesenchymal transition (EMT) in endometriotic lesions. The majority of ectopic epithelial glands (93.1 %, n = 72) display ...
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Abstract null null There is some evidence for ameliorating effect of vitamin D on glycemic and lipidemic status which are likely to be mediated through other molecules including adiponectin. However, the overall results have been controversial. This study was conducted to evaluate the effect of vitamin D supplementation on serum adiponectin concentration. MEDLINE, PubMed, Embase, Cochrane Library, and Google Scholar were searched and 402 studies were found in a preliminary search. After screenin...
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#1Francis Quilty (Trinity College, Dublin)H-Index: 1
#2Michael Freeley (DCU: Dublin City University)H-Index: 13
Last. Aideen Long (Trinity College, Dublin)H-Index: 31
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The bile acid component of gastric refluxate has been implicated in inflammation of the oesophagus including conditions such as gastro-oesophageal reflux disease (GORD) and Barrett's Oesophagus (BO). Here we demonstrate that the hydrophobic bile acid, deoxycholic acid (DCA), stimulated the production of IL-6 and IL-8 mRNA and protein in Het-1A, a model of normal oesophageal cells. DCA-induced production of IL-6 and IL-8 was attenuated by pharmacologic inhibition of the Protein Kinase C (PKC), MA...
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#1Samira Shirooie (Kermanshah University of Medical Sciences)H-Index: 10
#2Ehsan Khaledi (Kermanshah University of Medical Sciences)
Last. Eduardo Sobarzo-Sánchez (University of Santiago de Compostela)H-Index: 24
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BACKGROUND One of the most common reasons for infertility is polycystic ovary syndrome (PCOS). PCOS is related to metabolic syndrome, weight gain, type 2 diabetes mellitus, and cardiovascular diseases. Some of the causes of PCOS are dysfunction in the hypothalamus-pituitary-ovarian axis, insulin activity as well as over-activity of sympathetic nerves and elevation in serum levels of pro-inflammatory cytokines. Dapsone, a sulfonamide antibacterial agent, has anti-inflammatory effects such as decr...
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#1Lu Li (SWU: Southwest University)H-Index: 1
#2You Wu (SWU: Southwest University)H-Index: 1
Last. Deshou Wang (SWU: Southwest University)H-Index: 31
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Sex steroids play critical roles in sex differentiation and gonadal development in teleosts. Steroidogenic acute regulatory protein (StAR), transporting cholesterol (the substrate for steroidogenesis) from the outer mitochondrial membrane to the inner membrane, is the first rate-limiting factor of steroidogenesis. Interestingly, two StAR genes (named as StAR1 and StAR2) have been isolated from non-mammalian vertebrates. To characterize the functions of the novel StAR2 gene in the gonadal differe...
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