The Journal of Steroid Biochemistry and Molecular Biology
Papers 6,883
1 page of 689 pages (6,883 results)
#1Fatemeh Meshkini (Shahid Sadoughi University of Medical Sciences and Health Services)H-Index: 3
#2Sepideh Soltani (Shahid Sadoughi University of Medical Sciences and Health Services)H-Index: 11
Last. Shima AbdollahiH-Index: 6
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Previous studies of the effect of vtamin D on serum levels of fibroblast growth factor- 23 (FGF-23) have yeilded an inconsistent findings. This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to investigate the effect of vitamin D supplementation on serum levels of FGF-23. PubMed, Scopus, ISI Web of Science, and the Cochrane Library were searched, from database inception to November 2020, for RCTs that evaluated the effects of native or active vitamin D suppleme...
#1Xueying Ye (STU: Shantou University)H-Index: 4
#2Tao Peng (STU: Shantou University)H-Index: 6
Last. Zhong Hu (STU: Shantou University)H-Index: 19
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Abstract null null Nowadays, 17β-estradiol (E2) biodegradation pathway has still not been identified in bacteria. To bridge this gap, we have described a novel E2 degradation pathway in Rhodococcus sp. P14 in this study, which showed that estradiol could be first transferred to estrone (E1) and thereby further converted into 16-hydroxyestrone, and then transformed into opened estrogen D ring. In order to identify the genes, which may be responsible for the pathway, transcriptome analysis was per...
#1Renata L. Goto (UNESP: São Paulo State University)H-Index: 1
#2Mariana Baptista Tablas (UNESP: São Paulo State University)H-Index: 3
Last. Guilherme Ribeiro Romualdo (UNESP: São Paulo State University)H-Index: 9
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Abstract null null Vitamin D3 (VD3) deficiency has been associated with increased risk for cirrhosis and hepatocellular carcinoma, a highly incident malignant neoplasia worldwide. On the other hand, VD3 supplementation has shown some beneficial effects in clinical studies and rodent models of chronic liver disease. However, preventive effects of dietary VD3 supplementation in cirrhosis-associated hepatocarcinogenesis is still unknow. To investigate this purpose, male Wistar rats submitted to a c...
#1Salah Gariballa (UAEU: United Arab Emirates University)H-Index: 32
#2Iltaf Shah (UAEU: United Arab Emirates University)H-Index: 15
Last. Awad Alessa (UAEU: United Arab Emirates University)H-Index: 5
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Abstract null null Background null Although both vitamin D deficiency and obesity are highly prevalent in the UAE, the role of vitamin D metabolites in mediating obesity-related adverse health effects is not clear. We aimed to assess the role of vitamin D metabolites as potential mediators in the association between obesity, inflammation and metabolic risk factors. null null null Methods null 277 participants who were part of a randomized controlled trial had their assessment that included clini...
#1Takako Kawakita (Tokushima University)H-Index: 6
#2Toshiyuki Yasui (Tokushima University)H-Index: 33
Last. Takeshi Iwasa (Tokushima University)H-Index: 18
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Associations of androstenediol, which has both androgenic and estrogenic activities, with circulating reproductive hormones and stress hormone in women during the menopausal transition may be different depending on the menopausal stage. The aim of this study was to determine the changes in circulating androstenediol during the menopausal transition in Japanese women and the associations of androstenediol with estrogen, androgen and cortisol for each stage of the menopausal transition. We divided...
Chemotherapy is a standard therapeutic option for triple-negative breast cancer (TNBC); however, its effectiveness is often compromised by drug-related toxicity and resistance development. Herein, we aimed to evaluate whether an improved antineoplastic effect could be achieved in vitro and in vivo in TNBC by combining dovitinib, a multi-kinase inhibitor, with calcitriol, a natural anticancer hormone. In vitro, cell proliferation and cell-cycle distribution were studied by sulforhodamine B-assays...
#1Alexey I. Ilovaisky (RAS: Russian Academy of Sciences)H-Index: 19
#2Valentina M. Merkulova (RAS: Russian Academy of Sciences)H-Index: 15
Last. Alexander O. Terent'ev (RAS: Russian Academy of Sciences)H-Index: 30
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Abstract null null A convenient and selective approach to 13,17-secoestra-1,3,5(10)-trien-17-oic acid hydrazides and their N’-(het)arylmethylene derivatives was disclosed and these novel types of secosteroids were screened for cytotoxicity against hormone-dependent human breast cancer cell line MCF-7. A number of 13,17-secoestra-1,3,5(10)-trien-17-oic acid [N’-(het)arylmethylene]hydrazides show significant cytotoxic effect comparable or superior to that for reference drug cisplatin. Compound 3l ...
#1Zhong-Rui Du (Ludong University)H-Index: 1
#2Gu Yu (Qingdao University)H-Index: 1
Last. Wen-Fang Chen (Qingdao University)H-Index: 9
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Abstract null null Neuroinflammation plays an important role in the pathogenesis of Parkinson's disease (PD). Genistein is an estrogen-like phytoestrogen that can exert biological effects via the crosstalk of estrogen receptor and insulin-like growth factor 1 receptor (IGF-1R). The present study aimed to evaluate the involvement of G protein-coupled estrogen receptor (GPER) and IGF-1R in the anti-inflammatory effects of genistein against lipopolysaccharide (LPS)-induced nigrostriatal injury in o...
#1Alexandra E. Butler (Royal College of Surgeons in Ireland - Bahrain)H-Index: 1
#2Abu Saleh Md Moin (Royal College of Surgeons in Ireland - Bahrain)H-Index: 1
Last. Stephen L. Atkin (Royal College of Surgeons in Ireland - Bahrain)H-Index: 63
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Vitamin D deficiency is a negative endocrine renin-angiotensin system (RAS) modulator and PCOS women are often vitamin D deficient, leading to RAS overactivation in PCOS. A cross-sectional study was performed in 99 PCOS and 68 control women who presented sequentially. Circulating plasma levels of RAS proteins (Angiotensin-converting enzyme 2 (ACE2), renin and angiotensinogen) were measured by Slow Off-rate Modified Aptamer (SOMA)-scan and 25-hydroxyvitamin D [25(OH)D] was measured by tandem mass...
#1Shumin Li (SDU: Shandong University)
Last. Shigang Zhao (SDU: Shandong University)H-Index: 12
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Abstract null null Background null Valproate (VPA) is an antiepileptic drug (AEDs) with an ideal effect against epilepsy as well as other neuropsychiatric diseases. There is considerable evidence that women taking VPA are prone to reproductive endocrine disorders. However, few studies have been published about VPA effects on human ovarian granulosa cells. null null null Methods null By treating human ovarian granulosa cell line KGN with VPA, the cell viability and progesterone production functio...
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