The Journal of Steroid Biochemistry and Molecular Biology
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#1Abhishek Shetty (MU: Mangalore University)H-Index: 2
#2Padmanaban S. Suresh (NITC: National Institute of Technology Calicut)H-Index: 7
Abstract Obesity increases the risk of developing cancers for both males and females. This study investigated potential crosstalk between estradiol and leptin signaling pathways within the endometrium of high-fat-diet-induced obese ovariectomized mice to gain insight into possible links between obesity and endometrial cancer. We administered 17-β estradiol (0.2 μg/mouse subcutaneously) and/or recombinant mouse leptin (1 μg/g Bwt intraperitoneally.,) for 20 h to high-fat-diet-induced obese ovarie...
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#1Natalia Hetemäki (UH: University of Helsinki)H-Index: 1
#2Tomi S. Mikkola (UH: University of Helsinki)H-Index: 23
Last. Hanna Savolainen-Peltonen (UH: University of Helsinki)H-Index: 13
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Abstract Objective Although the ovaries produce the majority of estrogens in women before menopause, estrogen is also synthesized in peripheral tissues such as adipose tissue (AT). The typical female AT distribution, concentrated in subcutaneous and femoro-gluteal regions, is estrogen-mediated, but the significance of estrogen synthesis in AT of premenopausal women is poorly understood. Design and Methods Serum and subcutaneous and visceral AT homogenates from 28 premenopausal women undergoing n...
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#1Saba Nikanfar (Tabriz University of Medical Sciences)H-Index: 1
#2Hajar Oghbaei (Tabriz University of Medical Sciences)H-Index: 5
Last. Ralf Dittrich (FAU: University of Erlangen-Nuremberg)H-Index: 32
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Abstract Adipokines are mainly produced by adipose tissue; however, their expression has been reported in other organs including female reproductive tissues. Therefore, adipokines have opened new avenues of research in female fertility. In this regard, studies reported different roles for certain adipokines in ovarian function, although the role of other recently identified adipokines is still controversial. It seems that adipokines are essential for normal ovarian function and their abnormal le...
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Abstract Estrogen receptor subtype α (ERα) plays key roles in breast cancers, and has been a target for endocrine therapy for a long time. Unfortunately, long-term treatment by Aromatase Inhibitors (AIs) or Selective Estrogen Receptor Modulators (SERMs) could cause drug resistance and also would increase the risk for uterine cancer. Therefore, novel anti-breast cancer drugs based on different mechanisms of action have received significant attention, especially through the strategies of selective...
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#1Chi Sun Liau (RCSI: Royal College of Surgeons in Ireland)
#2Praveena Mogan (RCSI: Royal College of Surgeons in Ireland)
Last. Warren Thomas (RCSI: Royal College of Surgeons in Ireland)H-Index: 21
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Abstract Infantile hypercalcemia (IH), is a rare disorder caused by CYP24A1 or SLC34A1 variants which lead to disturbed catabolism of 25(OH)D3 and 1,25(OH)2D3 or increased generation of 1,25(OH)2D3. Aim of study To assess the status of 24,25(OH)2D3 and other markers of vitamin D in IH survivors, in whom variants of CYP24A1 or SLC34A1 gene were found and to compare these unique biochemical features with those obtained from subjects who were diagnosed in the first year of life with hypercalcemia, ...
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#1E. O. YablokovH-Index: 6
#1E.O. YablokovH-Index: 1
Last. Natallia Strushkevich (Skolkovo Institute of Science and Technology)H-Index: 1
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1 CitationsSource
#1Melina A. Dattilo (UBA: University of Buenos Aires)H-Index: 3
#2Yanina Benzo (UBA: University of Buenos Aires)H-Index: 1
Last. Paula Maloberti (UBA: University of Buenos Aires)H-Index: 19
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Abstract Consanguinity increases the risk of hereditary diseases including disorders of sex development (DSD). There are minimal data on DSD in the highly consanguineous population of Saudi Arabia. This study reports the molecular genetics of a series of patients with different types of DSD. Methods We enrolled 77 patients from 47 families with DSD. DNA was isolated from peripheral leucocytes. Genes of interest were amplified by polymerase chain reaction and subsequently sequenced. Results Overa...
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#1Sarah M. Glass (Vandy: Vanderbilt University)H-Index: 3
#2Michael J. Reddish (ASU: Appalachian State University)H-Index: 9
Last. F. Peter Guengerich (Vandy: Vanderbilt University)H-Index: 90
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Abstract Cytochrome P450 (P450) 11B1 and 11B2 both catalyze the 11β-hydroxylation of 11-deoxycorticosterone and the subsequent 18-hydroxylation of the product. P450 11B2, but not P450 11B1, catalyzes a further C-18 oxidation to yield aldosterone. 11-Oxygenated androgens are of interest, and 11-hydroxy progesterone has been reported to be a precursor of these. Oxidation of progesterone by purified recombinant P450 11B2 yielded a mono-hydroxy derivative as the major product, and co-chromatography ...
3 CitationsSource
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