Original paper
Survivin promotion of melanoma metastasis requires upregulation of α 5 integrin
Abstract
Survivin is an apoptotic and mitotic regulator that is overexpressed in melanoma and a poor prognostic marker in patients with metastatic disease. We recently showed that Survivin enhances melanoma cell motility through Akt-dependent upregulation of α5 integrin. However, the functional role of Survivin in melanoma metastasis is not clearly understood. We found that overexpression of Survivin in LOX and YUSAC2 human melanoma cells increased...
Paper Details
Title
Survivin promotion of melanoma metastasis requires upregulation of α 5 integrin
Published Date
May 2, 2013
Journal
Volume
34
Issue
9
Pages
2137 - 2144
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Notes
History