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#1Jiahui Mou (Shanghai Institute of Materia Medica)
#2Xiaoding Xu (NJUCM: Nanjing University of Chinese Medicine)
Last. Jin Ren (Shanghai Institute of Materia Medica)
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Abstract High-mobility group nucleosome-binding domain 4 (HMGN4) exerts biological functions by regulating gene transcription through binding with nucleosome. As a new epigenetic regulator discovered in 2001, its biological functions have not been clarified. HMGN4 belongs to HMGNs family, in which HMGN1, 2, and 5 have been reported to play roles in oncogenesis of various cancers. However, it is reported that HMGN4 was associated with thyroid and liver cancer. In this study, we discovered for the...
#1Mitsuru Yanagaki (Jikei University School of Medicine)H-Index: 2
#2Yoshihiro Shirai (Jikei University School of Medicine)H-Index: 12
Last. Hiroshi Kobayashi (Jikei University School of Medicine)
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Abstract Sphingolipid metabolism plays an important role in the formation of cellular membranes and is associated with malignant potential and chemosensitivity of cancer cells. Sphingolipid degradation depends on multiple lysosomal glucosidases. We focused on acid β-glucosidase (GBA), a lysosomal enzyme the deficiency of which is related to mitochondrial dysfunction. We analyzed the function of GBA in pancreatic ductal adenocarcinoma (PDAC). Human PDAC cell lines (PANC-1, BxPC-3, and AsPC-1) wer...
Last. Jie Hu (Fudan University)
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Liver metastasis is a leading indicator of poor prognosis in patients with colorectal cancer (CRC). Exosomal intercellular communication has been reported to play an important role in cancer invasion and metastasis. Here, we characterized exosomal miRNAs underlying liver metastasis in CRC patients (Cohort 1, n = 30) using miRNA arrays. Exosomal miR-150 was found to be down-regulated in CRC patients with liver metastases compared to those without (P = 0.025, Fold Change = 2.01). These results wer...
#1Kun-Ming Chen (PSU: Pennsylvania State University)
#2Yuan-Wan Sun (PSU: Pennsylvania State University)
Last. Karam El-Bayoumy (PSU: Pennsylvania State University)H-Index: 45
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Abstract Polycyclic aromatic hydrocarbons (PAHs) are recognized as potential etiological agents in the development of oral cancer in smokers. In particular, benzo[a]pyrene (B[a]P) and dibenzo[def,p]chrysene (DB[a,l]P) are detected in cigarette smoke and the environment and can induce DNA damage, mutagenesis and carcinogenesis in the oral cavity of rodents. Consequently, DNA adducts are regarded as the most direct markers of genotoxicity and can be used as biomarkers of cancer risk. Thus, this st...
#1Neha Jaiswal (University of Delhi)
#2Deeptashree Nandi (University of Delhi)
Last. Alo Nag (University of Delhi)H-Index: 19
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Abstract The transforming properties of the high risk human papillomavirus (HPV) E7 oncoprotein are indispensable for driving the virus life cycle and pathogenesis. Besides inactivation of the retinoblastoma family of tumor suppressors as part of its oncogenic endeavors, E7-mediated perturbations of eminent cell cycle regulators, checkpoint proteins and proto-oncogenes are considered to be the tricks of its transformative traits. However, many such critical interactions are still unknown. In the...
#1Jian Feng (Shanghai Chest Hospital)
#2Huiling Ouyang (SJTU: Shanghai Jiao Tong University)
Last. Deshui Jia (SJTU: Shanghai Jiao Tong University)
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Abstract Non-small cell lung cancer (NSCLC), accounting for 85% of all lung cancer, is one of the leading causes of cancer-related death worldwide. Previously, we demonstrated that MPZL1 gene amplification promotes liver cancer metastasis through activating Src/Cortactin pathway. However, the clinical relevance and biological roles of the MPZL1 gene in lung cancer are still unknown. Here, we found that MPZL1 expression upregulates in human NSCLC, which is partly due to the copy number amplificat...
#1Xiaohong Guo (Shandong Provincial QianFoShan Hospital)
#2Longtao Yue (Shandong Provincial QianFoShan Hospital)
Last. Qing Sun (Shandong Provincial QianFoShan Hospital)
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Abstract Colorectal cancer is the predominant cause of cancer-related death worldwide, because of lack of effective therapeutic targets. Estrogen-related receptor gamma (ESRRG), which belongs to the family of nuclear receptors, functions as an important element regulating gene transcription. In our report, we identified ESRRG as a potential tumor suppressor. The decreased level of ESRRG was initially observed in CRC and was highly associated with poor prognosis. ESRRG overexpression abrogated ce...
#1Si-Li He (Third Xiangya Hospital)
#2Xingping Zhao (Third Xiangya Hospital)
Last. Shui-Jing Yi (Third Xiangya Hospital)
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Recent studies highlighted non-coding RNAs as potential therapeutic targets in ovarian cancer. We aimed to investigate the roles of circAHNAK in ovarian cancer pathogenesis. Here, RNA immunoprecipitation, dual-luciferase reporter assay, and RNA fluorescence in situ hybridization were adopted to determine circAHNAK, miR-28, or EIF2B5 interaction. CCK-8 assay was used to detect cell proliferation. Wound healing and Transwell assays were employed to assess cell migration and invasion, respectively....
#1Yinxing Zhu (NMU: Nanjing Medical University)
#2Yixuan Hu (NMU: Nanjing Medical University)
Last. Wenwen Zhang (NMU: Nanjing Medical University)H-Index: 18
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Abstract To improve the early detection of gastric cancer (GC), there is a growing need for novel and efficient biomarkers. We aimed to evaluate diagnostic value of thioredoxin reductase 1 (TXNRD1), which was found to be overexpressed in various malignancies. We found that TXNRD1 has a higher expression level in GC tissues compared with adjacent normal tissues, and high TXNRD1 expression was significantly associated with poor outcomes of GC patients. Next, a total of 1446 cases were collected, w...
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