Carcinogenesis
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4.60
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12359
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#1Ping Zhu (Fudan University)
#2Jingjing Lu (Fudan University)
Last. Yang bai Sun (Fudan University)
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tRNA-derived fragments (tRFs) are a novel class of small non-coding RNAs (sncRNAs) whose biological roles are not well defined. Here, using multiple approaches, we investigated its role in human triple-negative breast cancer (TNBC). Our genome-wide transcriptome analysis of sncRNAs revealed that tRF Lys-CTT-010 was significantly increased in human TNBC. It promoted TNBC proliferation and migration. It also closely associated with starch and sucrose metabolism pathways (KEGG analysis) and positiv...
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#1Kaili Du (Kunming Medical University)H-Index: 5
#2Xinliang Zhang (Xi'an Jiaotong University)H-Index: 3
Last. Ying Huang (Kunming Medical University)H-Index: 1
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The misregulation of transforming growth factor-β (TGF-β) signaling can cause tumorigenesis, but the activation and suppression of TGF-β signaling are complicated biological processes. We discovered a protein tyrosine phosphatase nonreceptor 3 (PTPN3)-dependent regulatory mechanism in uncancerous osteoblast cells that involved a stabilizing PTPN3 interaction with the TGF-β type I receptor (TGFBR1), which impaired TGFBR1 ubiquitination by the Smurf2 (Smad ubiquitination regulatory factor 2) E3 li...
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#1Alexandra J. White (NIH: National Institutes of Health)H-Index: 18
#2Dale P. Sandler (NIH: National Institutes of Health)H-Index: 103
Last. Katie M. O'Brien (NIH: National Institutes of Health)H-Index: 20
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We evaluated whether hair products, which may contain carcinogens and endocrine disruptors that can be absorbed into the bloodstream, are related to ovarian cancer incidence in a prospective cohort. After excluding women with a history of ovarian cancer or bilateral oophorectomy, 40,559 Sister Study participants ages 35-74 at enrollment (2003-2009) were included. Participants completed questionnaires on hair product use, including hair dyes, straighteners/relaxers and permanents/body waves, in t...
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#1Yu ZhengH-Index: 2
Last. Changqing ZengH-Index: 2
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More and more studies indicated that extracellular vesicles (EVs) carrying miRNAs have been potential biomarkers of various cancers including colorectal cancer (CRC). This study aims to explore the function of miR-224-5p carried by EVs derived from cancer-associated fibroblasts (CAFs) in CRC. Here, we found that miR-224-5p was highly expressed while SLC4A4 was lowly expressed in CRC cells. Moreover, dual-luciferase reporter gene assay testified that miR-224-5p targeted SLC4A4. The expression of ...
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#1Yunmei Dong (Sichuan University)H-Index: 1
#2Zhen Wang (Sichuan University)H-Index: 2
Last. Qianming Chen (Sichuan University)H-Index: 50
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Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in the head and neck with a poor prognosis. Oral cancer development is a multistep process involving carcinogenesis. Though significant advances in cancer immunotherapy over the years, there is lack of evidence for T cell exhaustion during oral carcinogenesis. Clinical specimens from healthy donors and patients diagnosed with oral leukoplakia (OLK) or OSCC were collected for immunohistochemical staining with PD-L1, CD86, ...
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#1Jianfeng Xian (Guangzhou Medical University)H-Index: 4
#2Yuyuan Zeng (Guangzhou Medical University)H-Index: 1
Last. Lei Yang (Guangzhou Medical University)H-Index: 21
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A non-invasive method to distinguish potential lung cancer patients would improve lung cancer prevention. We employed the RNA-Seq analysis to profile serum exosomal long non-coding RNAs (lncRNAs) from non-small cell lung cancer (NSCLC) patients and pneumonia controls, and then determined the diagnostic and prognostic value of a promising lncRNA in four datasets. We identified 90 dysregulated lncRNAs for NSCLC and found the most significant lncRNA was a novel isoform of linc01125. Serum exosomal ...
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#1Shama Virani (IARC: International Agency for Research on Cancer)H-Index: 1
#1Shama Virani (IARC: International Agency for Research on Cancer)H-Index: 1
Last. Britton Trabert (NIH: National Institutes of Health)H-Index: 38
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Recently, ovarian cancer research has evolved considerably because of the emerging recognition that rather than a single disease, ovarian carcinomas comprise several different histotypes that vary by etiologic origin, risk factors, molecular profiles, therapeutic approaches, and clinical outcome. Despite significant progress in our understanding of the etiologic heterogeneity of ovarian cancer, as well as important clinical advances, it remains the eighth most frequently diagnosed cancer in wome...
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#1Irit Zurer (Weizmann Institute of Science)H-Index: 9
#2Lorne J. Hofseth (NIH: National Institutes of Health)H-Index: 51
Last. Varda Rotter (Weizmann Institute of Science)H-Index: 89
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#1Lin Zhu (Sichuan University)
#2Jing Wu (Sichuan University)
Last. Hong Liu (Sichuan University)
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The Homologous to E6AP C-terminus (HECT) domain and RCC1-like domain-containing (HERC) proteins can function as tumour suppressors and as oncogenes, depending on the cancer type. However, the expression patterns of HERCs in colorectal cancer (CRC) cells are unclear. Here, we show that only HERC1 and HERC5 are downregulated in CRC tumours, and we focus our study on revealing HERC5-mediating signalling because the change in downregulation is much more obvious for HERC5 than for HERC1. We demonstra...
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#1Kaiyi Tao (CAS: Chinese Academy of Sciences)
#2Jinshi Liu (CAS: Chinese Academy of Sciences)
Last. Weimin Mao (CAS: Chinese Academy of Sciences)
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This study tried to explore the molecular mechanism underlying progression of lung adenocarcinoma (LUAD), and discuss the extracellular communication between cancer cells and vascular endothelial cells. Roughly, differential analysis was carried out to note that miR-30a-5p was lowly expressed in LUAD while CCNE2 was highly expressed. Cell functional experiments demonstrated that overexpressed miR-30a-5p led to suppressed cell abilities in proliferation, migration and invasion. Dual-luciferase re...
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Carcinogen
Molecular biology
Chemistry
Biochemistry
Carcinogenesis
Biology