KIT genetic alterations in anorectal melanomas

Mucosal melanomas (MM) represent a heterogeneous tumour population that exhibits site-specific molecular profiles.In a multicentre retrospective study, we investigated KIT aberrations in primary anorectal (AR) melanomas compared with melanoma metastatic to the gastrointestinal (GI) tract.Primary AR MM (n=31) and GI metastatic melanoma (n=27) were studied for KIT mutations on exons 11, 13, 17 and 18 by high-resolution melting analysis, direct...