Journal of Clinical Pathology
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#1Mirna Elghobashy (University of Birmingham)
#2Lutful Wahab (West Hertfordshire Hospitals NHS Trust)
Last. Clinton Boyd (Belfast Health and Social Care Trust)H-Index: 5
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Aims null There is little information on the impact of COVID-19 on breast pathologists. This survey assessed the effect of the COVID-19 pandemic on UK and Ireland-based breast pathologists to optimise working environments and ensure preparedness for potential future pandemics. null Methods null A 35-question survey during the first wave of COVID-19 infections in the UK including questions on workload, working practices, professional development, training, health and safety and well-being was dis...
Aims null Recently, a new automated digital cell imaging analyser (Sysmex CellaVision DC-1), intended for use in low-volume and small satellite laboratories, has become available. The purpose of this study was to compare the performance of the DC-1 with the Sysmex DI-60 system and the gold standard, manual microscopy. null Methods null White blood cell (WBC) differential counts in 100 normal and 100 abnormal peripheral blood smears were compared between the DC-1, the DI-60 and manual microscopy ...
#1Juliana Cunha (USP: University of São Paulo)
#2Rodrigo B. Gonçalves (USP: University of São Paulo)H-Index: 12
Last. José Roberto Filassi (USP: University of São Paulo)H-Index: 15
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Aims null To correlate the ‘Residual Cancer Burden’ (RCB) index with overall survival (OS) and disease-free survival (DFS) in women undergoing neoadjuvant chemotherapy at the Cancer Institute of the State of Sao Paulo. null Methods null We analysed the medical records of patients with breast cancer who underwent neoadjuvant chemotherapy and breast surgery, from 2011 to December 2017. Variables analysed were age, clinical and pathological staging, molecular subtype, number of recurrences or metas...
#2Elizabeth Walker (Barts Health NHS Trust)
Last. Chris Scott (Barts Health NHS Trust)H-Index: 2
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The World Allergy Organisiation/European Academy of Allergy and Clinical Immunology (WAO/EAACI) 2017/2018 guidelines recommend measuring complement4 levels, followed by C1-inhibitor level and function for diagnosis of hereditary angioedema (HAE). We analysed 6 months' worth of data generated in our laboratory which is a specialist regional immunology service and also provides laboratory service for the Barts Health immunology department, which is a GA2LEN/HAEi-Angioedema Centre of Excellence and...
#1Ethan Gantana (National Health Laboratory Service)
#2Nomusa Mashigo (National Health Laboratory Service)
Last. Zivanai C. Chapanduka (National Health Laboratory Service)
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Aim null To compare the frequently used CD138 immunohistochemistry-based method of plasma cell quantitation, to a proposed new method, using interobserver and intraobserver concordance parameters. null Methods null Archival CD138 immunohistochemically stained slides made from paraffin-embedded bone marrow biopsies of 33 patients with a confirmed diagnosis of multiple myeloma were used. Light microscopic examination was performed using low magnification lenses (10×) for both the overview estimati...
Dermot Hourihane was born in Ballina, County Mayo, but his family soon moved to Dublin where he was educated. He studied medicine at University College Dublin and interned at St Vincent’s Hospital in Dublin where he began his pathology career under Professor John (Jock) McGrath. He continued his training in London at the Hammersmith Hospital and the London Hospital (later the Royal London Hospital) where his mentors included Sir John Dacie, and Professors Israel Doniach, Victor Hoffbrand and Joh...
#1Michael J AllenH-Index: 2
#2Amy Zhang (OICR: Ontario Institute for Cancer Research)H-Index: 7
Last. Julie M. Wilson (OICR: Ontario Institute for Cancer Research)H-Index: 12
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Aims null The majority of pancreatic ductal adenocarcinomas (PDACs) harbour oncogenic mutations in KRAS with variants in TP53, CDKN2A and SMAD4 also prevalent. The presence of oncogenic fusions including NTRK fusions are rare but important to identify. Here we ascertain the prevalence of NTRK fusions and document their genomic characteristics in a large series of PDAC. null Methods null Whole genome sequencing and RNAseq were performed on a series of patients with resected or locally advanced/me...
#1Friederike Kullmann (FAU: University of Erlangen-Nuremberg)
#2Pamela L. Strissel (FAU: University of Erlangen-Nuremberg)H-Index: 36
Last. Helge Taubert (FAU: University of Erlangen-Nuremberg)H-Index: 54
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Aims null Upper tract urothelial carcinoma (UTUC) is a rare malignancy with a poor prognosis which occurs sporadically or in few cases results from a genetic disorder called Lynch syndrome. Recently, examination of microsatellite instability (MSI) has gained importance as a biomarker: MSI tumours are associated with a better response to immunomodulative therapies. Limited data are known about the prevalence of MSI in UTUC. New detection methods using the fully automated Idylla MSI Assay facilita...
The assessment of cell proliferation is a key morphological feature for diagnosing various pathological lesions and predicting their clinical behaviour. Visual assessment of mitotic figures in routine histological sections remains the gold-standard method to evaluate the proliferative activity and grading of cancer. Despite the apparent simplicity of such a well-established method, visual assessment of mitotic figures in breast cancer (BC) remains a challenging task with low concordance among pa...
#1Theodore Estrin-Serlui (Imperial College Healthcare)
#2Michael Osborn (Imperial College Healthcare)H-Index: 10
Aims null The aim of this study is to evaluate whether there has been a significant change in the frequency of markedly decomposed bodies having coronial autopsies since the UK’s first COVID-19 lockdown. null Methods null We compared coronial autopsies (n=263) performed by one pathologist at a central London mortuary in the 1 year before and after 23 March 2020 by analysing their autopsy reports and coronial documentation. null Results null We have shown that there has been a significant increas...
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