Journal of Clinical Pathology
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#1Cornelia Margaret Szecsei (North Bristol NHS Trust)H-Index: 1
#2Jon Oxley (North Bristol NHS Trust)H-Index: 16
1 CitationsSource
#1Owen J Wiese (National Health Laboratory Service)H-Index: 1
#2Annalise E Zemlin (National Health Laboratory Service)H-Index: 12
Last. Tahir S. PillayH-Index: 22
view all 3 authors...
The renin–angiotensin system is mainly associated with the regulation of blood pressure, but recently many other functions of this system have been described. ACE2, an 805-amino acid monocarboxypeptidase type I transmembrane glycoprotein, was discovered in 2000 and has sequence similarity to two other proteins, namely ACE and collectrin. The ACE2 gene is located on Xp22 and is highly polymorphic. ACE2 is expressed in numerous tissues especially the lung alveolar epithelial cells, heart, kidney a...
2 CitationsSource
This paper reviews recent academic research into the pathology of trauma of lightning. Lightning may injure or kill in a variety of different ways. Aimed at the trainee, or practicing pathologist, this paper provides a clinicopathological approach.
#1Murali Varma (University Hospital of Wales)H-Index: 18
#2W. Glenn McCluggageH-Index: 44
Last. Daniel M. Berney (QMUL: Queen Mary University of London)H-Index: 54
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#1Ravindra Kumar (ICMR: Indian Council of Medical Research)H-Index: 41
#2Sweta Mishra (ICMR: Indian Council of Medical Research)H-Index: 2
Last. Rajasubramaniam Shanmugam (ICMR: Indian Council of Medical Research)H-Index: 2
view all 7 authors...
#1Takayuki Kiuchi (Hokkaido University)H-Index: 5
#2Utano Tomaru (Hokkaido University)H-Index: 25
Last. Masanori Kasahara (Hokkaido University)H-Index: 51
view all 12 authors...
#1Shaun S. TanH-Index: 4
#2Benedict YanH-Index: 24
Last. Sunil SethiH-Index: 24
view all 7 authors...
The coronavirus disease 2019 (COVID-19) is a zoonotic viral infection originating from Wuhan, China in December 2019. The World Health Organization has classified this pandemic as a global health emergency due to its virulent nature of transmission, which may lead to acute respiratory distress syndrome. Singapore’s health ministry has responded with enhanced surveillance of COVID-19 for all suspected pneumonia cases, further increasing the volume of testing via real-time reverse transcription PC...
20 CitationsSource
#1Luisa ZupinH-Index: 9
#2Lorella PascoloH-Index: 22
Last. Sergio CrovellaH-Index: 38
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Unravelling the SARS-CoV-2 mechanism of entry into host cells is engaging the endeavours of researchers worldwide and, although angiotensin-converting enzyme 2 (ACE2) is recognised as the primary receptor, many issues remain to be investigated.1 Remarkably, the interaction between ACE2 and the spike (S) glycosylated protein of SARS-CoV-2 necessary for viral entry has been discovered by employing crystallography. S protein presents a receptor binding domain (RBD) and more specifically a receptor ...
5 CitationsSource
#1Daniel Payne (Leeds Teaching Hospitals NHS Trust)H-Index: 2
#2Darren J. Newton (University of Leeds)H-Index: 17
Last. Richard L Baretto (University Hospitals Birmingham NHS Foundation Trust)H-Index: 2
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Significant challenges exist to develop sensitive and specific tests to diagnose COVID-19 caused by infection with the RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).1 Diagnosis of COVID-19 in the acute stage relies on detecting SARS-CoV-2 genomic RNA in naso/oropharyngeal (NOP) swabs. The swab is transferred to the laboratory in either viral or universal transport medium (VTM/UTM) and reverse transcriptase PCR (RT-PCR) performed to detect SARS-CoV-2 RNA.1 This same algor...
5 CitationsSource
#1Giancarlo TronconeH-Index: 44
#2Paul Hofman (French Institute of Health and Medical Research)H-Index: 31
Last. Paul Hofman (French Institute of Health and Medical Research)H-Index: 62
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The current COVID-19 pandemic has imposed sweeping changes in every aspect of life, not least in the way pathologists carry out their practice. Severe acute respiratory syndrome coronavirus 2 spreads quickly from person to person through respiratory droplets released in the air by infected patients. Thus, respecting strict biosafety procedures while handling potentially infected fresh tissues, liquid samples or even air-dried fixed cytological preparations, has become paramount for pathologists....
8 CitationsSource
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