Deletion of the Herpes Simplex Virus 1 U _L 49 Gene Results in mRNA and Protein Translation Defects That Are Complemented by Secondary Mutations in U _L 41

Herpes simplex virus 1 (HSV-1) virions, like those of all herpesviruses, contain a protein layer termed the tegument localized between the capsid and the envelope. VP22, encoded by the U L 49 gene, is one of the most abundant tegument proteins in HSV-1 virions. Studies with a U L 49-null mutant showed that the absence of VP22 resulted in decreased protein synthesis at late times in infection. VP22 is known to form a tripartite complex with VP16...