Ekaette F. Mbong
University of California, San Diego
GeneMessenger RNAInternal medicineEndocrinologyViral replicationMutantViral tegumentMolecular biologyVirologyPoint mutationChemistryGonadotropic cellStimulationVirusGonadotropinViral proteinHerpes simplex virusHost cell membraneDefective virusFrameshift mutationGonadotropin secretionProtein biosynthesisEndocrine systemSecretionMutationFatty acidViral entryHomologous chromosomePolysomeHormoneBiologyViral envelope
4Publications
4H-index
82Citations
Publications 4
Newest
#1Song Li (UCSD: University of California, San Diego)H-Index: 2
#2Ekaette F. Mbong (UCSD: University of California, San Diego)H-Index: 4
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 6 authors...
: An emerging body of evidence supports the concept that the pituitary is a site for integration of multiple physiological and metabolic signals that inform and modulate endocrine pathways. Multiple endocrine mediators of energy balance and adiposity are known to impinge on the neuroendocrine axis regulating reproduction. Observations in humans show that obesity is correlated with decreased gonadotropin secretion, and studies have also suggested that pituitary sensitivity to stimulation by gonad...
7 CitationsSource
#1Ekaette F. Mbong (UA: University of Alabama)H-Index: 4
#2Lucille Woodley (UA: University of Alabama)H-Index: 2
Last. Carol Duffy (UA: University of Alabama)H-Index: 11
view all 6 authors...
Herpes simplex virus 1 (HSV-1) virions, like those of all herpesviruses, contain a protein layer termed the tegument localized between the capsid and the envelope. VP22, encoded by the UL49 gene, is one of the most abundant tegument proteins in HSV-1 virions. Studies with a UL49-null mutant showed that the absence of VP22 resulted in decreased protein synthesis at late times in infection. VP22 is known to form a tripartite complex with VP16 and vhs through direct interactions with VP16. Given th...
25 CitationsSource
#1Ekaette F. Mbong (UA: University of Alabama)H-Index: 4
#2Lucille Woodley (UA: University of Alabama)H-Index: 2
Last. Carol Duffy (UA: University of Alabama)H-Index: 11
view all 5 authors...
The herpes simplex virus 1 (HSV-1) UL21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel UL21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of UL21 results in a delay early in the HSV-1 replication...
17 CitationsSource
#1Carol Duffy (UA: University of Alabama)H-Index: 11
#2Ekaette F. Mbong (UA: University of Alabama)H-Index: 4
Last. Joel D. Baines (Cornell University)H-Index: 50
view all 3 authors...
Herpes simplex virus 1 (HSV-1) virions are composed of a nucleocapsid enclosing the double-stranded linear DNA genome, a proteinaceous layer termed the tegument that surrounds the nucleocapsid, and a host-derived lipid membrane envelope that contains viral glycoproteins. The tegument is unique to herpesviruses and is composed of at least 20 different viral proteins of varied stoichiometries. Tegument proteins have been shown to play a variety of roles in infection, including the regulation of vi...
34 CitationsSource