Journal of Virology
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#1Margarita A. Kurnaeva (MSU: Moscow State University)H-Index: 2
#2Arthur O. Zalevsky (RAS: Russian Academy of Sciences)H-Index: 5
Last. Anastasia I. Kachalova (MSU: Moscow State University)
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During evolution, viruses had to adapt to an increasingly complex environment of eukaryotic cells. Viral proteins that need to enter the cell nucleus or associate with nucleoli possess nuclear localization signals (NLSs) and nucleolar localization signals (NoLSs) for nuclear and nucleolar accumulation, respectively. As viral proteins are relatively small, acquisition of novel sequences seems to be a more complicated task for viruses than for eukaryotes. Here, we carried out a comprehensive analy...
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#1Alicja M Chmielewska (Gdańsk Medical University)
#2Maria Gómez-Herranz (University of Gdańsk)
Last. Borivoj VojtesekH-Index: 26
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Tick-borne encephalitis virus (TBEV), of the genus Flavivirus, is a causative agent of severe encephalitis in endemic regions of northern Asia and central and northern Europe. Interferon induced transmembrane proteins (IFITMs) are restriction factors that inhibit the replication cycles of numerous viruses, including flaviviruses such as the West Nile virus, dengue virus, and Zika virus. Here, we demonstrate the role of IFITM1, IFITM2, and IFITM3 in the inhibition of TBEV infection and in protect...
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#1Kento Fukano (NIH: National Institutes of Health)H-Index: 8
#2Mizuki Oshima (NIH: National Institutes of Health)H-Index: 2
Last. Masamichi Muramatsu (NIH: National Institutes of Health)H-Index: 52
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Sodium taurocholate cotransporting polypeptide (NTCP) is a receptor that is essential for hepatitis B virus (HBV) entry into the host cell. A number of HBV entry inhibitors targeting NTCP have been reported to date; these inhibitors have facilitated a mechanistic analysis of the viral entry process. However, the mechanism of HBV internalization into host cells after interaction of virus with NTCP remains largely unknown. Recently, we reported that troglitazone, a thiazolidinedione derivative, sp...
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#1Gregory A. Sowd (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Jiong Shi (VUMC: Vanderbilt University Medical Center)H-Index: 15
Last. Christopher Aiken (VUMC: Vanderbilt University Medical Center)H-Index: 55
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The HIV-1 capsid, composed of the CA protein, is the target of the novel antiretroviral drug lenacapavir (LCV). CA inhibitors block host factor binding and alter capsid stability to prevent nuclear entry and reverse transcription (RTN), respectively. Capsid stability is mediated in vitro by binding to the host cell metabolite inositol hexakisphosphate (IP6). IP6 depletion in target cells has little effect on HIV-1 infection. We hypothesized that capsid-altering concentrations of CA inhibitors mi...
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#1Li DanH-Index: 10
#2Panxue WuH-Index: 1
Last. Haixue ZhengH-Index: 16
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African swine fever (ASF), a devastating infectious disease in swine, severely threatens the global pig farming industry. Disease control has been hampered by the unavailability of vaccines. Here, we report that deletion of the QP509L and QP383R genes (ASFV-ΔQP509L/QP383R) from the highly virulent ASFV CN/GS/2018 strain results in complete viral attenuation in swine. Animals inoculated with ASFV-ΔQP509L/QP383R at a 104 50% hemadsorbing dose (HAD50) remained clinically normal during the 17-day ob...
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#1P. Bessiere (École nationale vétérinaire de Toulouse)
#2Figueroa T (École nationale vétérinaire de Toulouse)H-Index: 1
Last. Romain Volmer (École nationale vétérinaire de Toulouse)H-Index: 8
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Highly pathogenic avian influenza viruses (HPAIV) emerge from low pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely represents a minority variant within the index host, predominantly infected with the LPAIV precursor. Using reverse-genetics engineered H5N8 viruses differing solely at the HA cleavage, we tested the hypothesis that the interaction between the min...
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#1Chanakha K. Navaratnarajah (Mayo Clinic)H-Index: 15
#2David R Pease (Mayo Clinic)H-Index: 2
Last. Roberto Cattaneo (Mayo Clinic)H-Index: 87
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Severe cardiovascular complications can occur in coronavirus disease of 2019 (COVID-19) patients. Cardiac damage is attributed mostly to the aberrant host response to acute respiratory infection. However, direct infection of cardiac tissue by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also occurs. We examined here the cardiac tropism of SARS-CoV-2 in spontaneously beating human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). These cardiomyocytes express the an...
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#1Maria Vittoria Salvati (UNIPD: University of Padua)H-Index: 1
#2Claudio Salaris (UNIPD: University of Padua)H-Index: 2
Last. Cristiano Salata (UNIPD: University of Padua)H-Index: 17
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Crimean-Congo hemorrhagic fever (CCHF) is a severe disease of humans caused by CCHF virus (CCHFV), a biosafety level (BSL)-4 pathogen. Ticks of the genus Hyalomma are the viral reservoir and they represent the main vector transmitting the virus to its hosts during blood feeding. We have previously shown that CCHFV can persistently infect Hyalomma-derived tick cell lines. However, the mechanism allowing the establishment of persistent viral infections in ticks is still unknown. Hazara virus (HAZV...
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#1Chen Chen (HAU: Huazhong Agricultural University)H-Index: 116
#2Chengguang Zhang (HAU: Huazhong Agricultural University)H-Index: 2
Last. Ling Zhao (HAU: Huazhong Agricultural University)H-Index: 31
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Rabies, caused by rabies virus (RABV), is fatal to both humans and animals around the world. Effective clinical therapy for rabies has not been achieved, and vaccination is the most effective means of preventing and controlling rabies. Although different vaccines, such as live attenuated and inactivated vaccines, can induce different immune responses, different expression of pattern recognition receptors (PRRs) also causes diverse immune responses. Toll-like receptor 4 (TLR4) is a pivotal PRR th...
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#1Nicolas Romero (UGent: Ghent University)H-Index: 1
#2Herman Favoreel (UGent: Ghent University)H-Index: 36
The nuclear factor kappa B (NF-κB) pathway is known to integrate signaling associated with very diverse intra- and extracellular stressors including virus infections, and triggers a powerful (pro-inflammatory) response through the expression of NF-κB-regulated genes. Typically, the NF-κB pathway collects and transduces threatening signals at the cell surface or in the cytoplasm leading to nuclear import of activated NF-κB transcription factors. In the current work, we demonstrate that the swine ...
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