Journal of Virology
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#1Nozomi KuseH-Index: 11
#2Tomohiro Akahoshi (Kumamoto University)H-Index: 11
Last. Masafumi TakiguchiH-Index: 40
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Functional HIV-1-specific CD8+ T-cells primed from naive T-cells are expected to act as effector T-cells in a ''shock and kill'' therapeutic strategy for an HIV-1 cure since less functional HIV-1-specific CD8+ T-cells are elicited from memory T-cells in HIV-1-infected individuals on cART. CD8+ T-cells specific for HIV-1 conserved and protective epitopes are candidates of such T-cells. We here investigated the priming with STING ligand of CD8+ T-cells specific for HLA-B*52:01 or HLA-C*12:02-restr...
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#1Meng-Ting Luo (KIZ: Kunming Institute of Zoology)
#2Dan Mu (KIZ: Kunming Institute of Zoology)H-Index: 3
Last. Yong-Tang Zheng (KIZ: Kunming Institute of Zoology)H-Index: 60
view all 8 authors...
The host range of human immunodeficiency virus type 1 (HIV-1) is narrow. Therefore, using ordinary animal models to study HIV-1 replication, pathogenesis, and therapy is impractical. The lack of applicable animal models for HIV-1 research spurred our investigation on whether tree shrews (Tupaia belangeri chinensis), which are susceptible to many types of human viruses, can act as an animal model for HIV-1. Here, we report that tree shrew primary cells are refractory to wild-type HIV-1 but suppor...
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#1Sean A. Nelson (URMC: University of Rochester Medical Center)H-Index: 1
#2Thamotharampillai Dileepan (UMN: University of Minnesota)H-Index: 17
Last. Andrea J. Sant (URMC: University of Rochester Medical Center)H-Index: 39
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Lung-localized CD4 T cells play a critical role in the control of influenza virus infection and can provide broadly protective immunity. However, current influenza vaccination strategies primarily target influenza hemagglutinin (HA) and are administered peripherally to induce neutralizing antibodies. We have used an intranasal vaccination strategy targeting the highly conserved influenza nucleoprotein (NP) to elicit broadly protective lung localized CD4 T cell responses. The vaccine platform con...
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#1Khlood Alsulami (MUHC: McGill University Health Centre)
#2Naomi Bolastig (MUHC: McGill University Health Centre)
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NKG2C is an activating NK cell receptor encoded by a gene having an unexpressed deletion variant. Cytomegalovirus (CMV) infection expands a population of NKG2C+ NK cells with adaptive-like properties. Previous reports found that carriage of the deleted NKG2C- variant was more frequent in people living with HIV (PLWH) than in HIV- controls unexposed to HIV. The frequency of NKG2C+ NK cells positively correlated with HIV viral load (VL) in some studies and negatively correlated with VL in others. ...
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#1Yunhao Hu (CAU: China Agricultural University)H-Index: 2
#2Purui Ke (CAU: China Agricultural University)
Last. Hanchun Yang (CAU: China Agricultural University)H-Index: 32
view all 9 authors...
A critical step in replication of positive-stranded RNA viruses is the assembly of replication and transcription complexes (RTC). We have recently mapped the nonstructural protein (nsp) interaction network of porcine reproductive and respiratory syndrome virus (PRRSV) and provided evidence by truncation mutagenesis that the recruitment of viral core replicase enzymes (nsp9 and nsp10) to membrane proteins (nsp2, nsp3, nsp5 and nsp12) is subject to regulation. Here, we went further to discover an ...
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#1Kai Qin (UAB: University of Alabama at Birmingham)H-Index: 3
#2Sushma Boppana (UAB: University of Alabama at Birmingham)H-Index: 5
Last. Paul A. Goepfert (UAB: University of Alabama at Birmingham)H-Index: 61
view all 11 authors...
HIV frequently escapes CD8 T cell responses, leading to the accumulation of viral adaptations. We recently demonstrated that, during chronic HIV infection, adapted epitopes can promote dendritic cells (DC) maturation through direct CD8 T cell interactions and lead to enhanced HIV trans-infection of CD4 T cells. Here, we sought to determine the role of such adaptations following HIV MRKAd5 vaccination. We observed that vaccine-induced adapted epitope specific CD8 T cells promoted higher levels of...
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#1Mariah Hassert (SLU: Saint Louis University)H-Index: 6
#2Tara L. Steffen (SLU: Saint Louis University)H-Index: 3
Last. Amelia K. Pinto (SLU: Saint Louis University)H-Index: 23
view all 7 authors...
The 2015/16 Zika virus epidemic in South and Central America left the scientific community urgently trying to understand the factors that contribute to Zika virus pathogenesis. Because multiple other flaviviruses are endemic in areas where Zika virus emerged, it is hypothesized that a key to understanding Zika virus disease severity, is to study Zika virus infection in the context of prior flavivirus exposure. Human and animal studies have highlighted the idea that having been previously exposed...
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#1Chelsea M. Crooks (UW: University of Wisconsin-Madison)H-Index: 4
#2Andrea M. Weiler (UW: University of Wisconsin-Madison)H-Index: 20
Last. Thomas C. Friedrich (UW: University of Wisconsin-Madison)H-Index: 46
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Following the Zika virus (ZIKV) outbreak in the Americas, ZIKV was causally associated with microcephaly and a range of neurological and developmental symptoms, termed congenital Zika syndrome (CZS). The viruses responsible for this outbreak belonged to the Asian lineage of ZIKV. However, in-vitro and in-vivo studies assessing the pathogenesis of African-lineage ZIKV demonstrated that African-lineage isolates often replicated to high titer and caused more severe pathology than Asian-lineage isol...
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#1Alexander M Schin (NIH: National Institutes of Health)
#2Ulrike S. Diesterbeck (NIH: National Institutes of Health)H-Index: 2
Last. Bernard Moss (NIH: National Institutes of Health)H-Index: 169
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Poxviruses are exceptional in having a complex entry-fusion complex (EFC) that is comprised of eleven conserved proteins embedded in the membrane of mature virions. However, the detailed architecture is unknown and only a few bimolecular protein interactions have been demonstrated by co-immunoprecipitation from detergent-treated lysates and by cross-linking. Here, we adapted the tripartite split green fluorescent protein (GFP) complementation system in order to analyze EFC protein contacts withi...
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#1M. M. van Haaren (UvA: University of Amsterdam)
#2Laura E. McCoy (Scripps Research Institute)H-Index: 27
Last. MJ van Gils (UvA: University of Amsterdam)H-Index: 2
view all 16 authors...
The high HIV-1 viral diversity is a formidable hurdle for the development of an HIV-1 vaccine. Elicitation of broadly neutralizing antibodies (bNAbs) would offer a solution, but so far immunization strategies have failed to elicit bNAbs efficiently. To overcome the obstacles, it is important to understand the immune responses elicited by current HIV-1 envelope glycoprotein (Env) immunogens. To gain more insight, we characterized monoclonal antibodies (mAbs) isolated from rabbits immunized with E...
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