A Systematic Review of Comparative Efficacy of Treatments and Controls for Depression

Although previous meta-analyses have examined effects of antidepressants, psychotherapy, and alternative therapies for depression, the efficacy of these treatments alone and in combination has not been systematically compared. We hypothesized that the differences between approved depression treatments and controls would be small.The authors first reviewed data from Food and Drug Administration Summary Basis of Approval reports of 62 pivotal...