Effects of Genistein and Hormone‐Replacement Therapy on Bone Loss in Early Postmenopausal Women: A Randomized Double‐Blind Placebo‐Controlled Study

The natural isoflavone phytoestrogen genistein has been shown to stimulate osteoblastic bone formation, inhibit osteoclastic bone resorption, and prevent bone loss in ovariectomized rats. However, no controlled clinical trial has been performed so far to evaluate the effects of the phytoestrogen on bone loss in postmenopausal women. We performed a randomized double‐blind placebo‐controlled study to evaluate and compare with hormone‐replacement...