Journal of Bone and Mineral Research
Papers 9,803
1 page of 981 pages (9,803 results)
#1Xiaolin Ni (Peking Union Medical College Hospital)H-Index: 1
#2Yiming Feng (Peking Union Medical College Hospital)
Last. Weibo Xia (Peking Union Medical College Hospital)H-Index: 22
view all 25 authors...
Tumor-induced osteomalacia TIO is a rare paraneoplastic syndrome caused by excessive production of fibroblast growth factor 23 FGF23 by a tumor. Previous studies have revealed generalized mineralization defects and low areal bone mineral density aBMD in TIO. However, data on the bone microarchitecture in TIO are limited. In this study, we evaluated the microarchitecture in the peripheral distal radius and tibia and axial lumbar spine skeleton using high-resolution peripheral quantitative compute...
#1Mingming Yan (CSU: Central South University)
#2Xin Duan (WashU: Washington University in St. Louis)H-Index: 12
Last. Muhammad Farooq Rai (WashU: Washington University in St. Louis)H-Index: 22
view all 7 authors...
Ectopic calcification is an osteogenic process that leads to the formation of inappropriate bone within intra-articular soft tissues, often in response to injury or surgery. The molecular mechanisms governing this phenotype have yet to be determined. Using a population genetics approach, we identified an association of the kinesin superfamily member 26b (Kif26b) with injury-induced ectopic calcification through quantitative trait locus analysis of recombinant inbred mouse strains, consistent wit...
#1J. Everts-Graber (University of Bern)H-Index: 2
#2Daniel Lehmann (University of Bern)
Last. Thomas LehmannH-Index: 2
view all 10 authors...
Osteonecrosis of the jaw (ONJ) is a rare but serious adverse event associated with antiresorptive treatment. There is little evidence regarding the incidence of ONJ among patients with osteoporosis who are treated with denosumab versus bisphosphonates (BPs). The aim of this study was to determine the risk of ONJ in a real-world population. Subjects who underwent at least one dual-energy X-ray absorptiometry (DXA) examination were included in the osteoporosis register of the Swiss Society of Rheu...
#1Connor P. Dolan (A&M: Texas A&M University)H-Index: 6
#2Felisha M. Imholt (A&M: Texas A&M University)H-Index: 2
Last. Ken Muneoka (A&M: Texas A&M University)H-Index: 35
view all 17 authors...
Amputation of the mouse digit tip results in blastema-mediated regeneration. In this model, new bone regenerates de novo to lengthen the amputated stump bone resulting in a functional replacement of the terminal phalangeal element along with associated non-skeletal tissues. Physiological examples of bone repair, such as distraction osteogenesis and fracture repair, are well known to require mechanical loading. However, the role of mechanical loading during mammalian digit tip regeneration is unk...
#1Josef Lavicky (Masaryk University)
#2Magdalena Kolouskova (Masaryk University)H-Index: 1
Last. Jan Krivanek (Masaryk University)H-Index: 7
view all 13 authors...
Considerable amount of research has been focused on dentin mineralization, odontoblast differentiation, and their application in dental tissue engineering. However, very little is known about the differential role of functionally and spatially distinct types of dental epithelium during odontoblast development. Here we show morphological and functional differences in dentin located in crown and roots of mouse molar and analogous parts of continuously growing incisors. Using a reporter (DSPP-cerul...
#1Eric T. Rush (UMKC: University of Missouri–Kansas City)H-Index: 12
#2Britt JohnsonH-Index: 2
Last. Kathryn Dahir (VUMC: Vanderbilt University Medical Center)H-Index: 8
view all 14 authors...
X-linked hypophosphatemia (XLH), a dominant disorder caused by pathogenic variants in the PHEX gene, affects both sexes of all ages and results in elevated serum fibroblast growth factor 23 (FGF23) and below-normal serum phosphate. In XLH, rickets, osteomalacia, short stature, and lower limb deformity may be present with muscle pain and/or weakness/fatigue, bone pain, joint pain/stiffness, hearing difficulty, enthesopathy, osteoarthritis, and dental abscesses. Invitae and Ultragenyx collaborated...
#1Marie-Josée Bégin (University of Geneva)
#2Marie-Claude Audet (University of Geneva)
Last. Emmanuel Biver (University of Geneva)H-Index: 24
view all 13 authors...
Atypical femoral fractures (AFFs) occurring during the course of osteoporosis treatment usually lead to discontinuation of anti-resorptive (AR) drugs. However, the risk of fracture after an AFF is unknown. We conducted a follow-up study of patients with AFF matched 1:3 for age and gender with patients with a peripheral major osteoporotic fracture (pMOF), in the setting of a fracture liaison service, to investigate the incidence of subsequent low-trauma fractures. Fifty-five patients with AFF (95...
#1Makoto Tsujita (Memorial Hospital of South Bend)H-Index: 2
#2Yohei Doi (Osaka University)H-Index: 6
Last. Yoshihiko WataraiH-Index: 18
view all 13 authors...
Vitamin D deficiency, persistent hyperparathyroidism, and bone loss are common after kidney transplantation (KTx). However, limited evidence exists regarding the effects of cholecalciferol supplementation on parathyroid hormone (PTH) and bone loss after KTx. In this prespecified secondary endpoint analysis of a randomized controlled trial, we evaluated changes in PTH, bone metabolic markers, and bone mineral density (BMD). At 1 month post-transplant, we randomized 193 patients to an 11-month int...
#1Jessica L. Pierce (Georgia Regents University)H-Index: 8
#2Anuj K. Sharma (Georgia Regents University)H-Index: 3
Last. Meghan E. McGee-Lawrence (Georgia Regents University)H-Index: 28
view all 19 authors...
Hallmarks of aging-associated osteoporosis include bone loss, bone marrow adipose tissue (BMAT) expansion, and impaired osteoblast function. Endogenous glucocorticoid levels increase with age, and elevated glucocorticoid signaling, associated with chronic stress and dysregulated metabolism, can have a deleterious effect on bone mass. Canonical glucocorticoid signaling through the glucocorticoid receptor (GR) was recently investigated as a mediator of osteoporosis during the stress of chronic cal...
#1K Poole (University of Cambridge)H-Index: 3
#2Graham M. Treece (University of Cambridge)H-Index: 45
Last. Tristan Whitmarsh (University of Cambridge)H-Index: 10
view all 15 authors...
This research was funded by Amgen and supported by the NIHR Cambridge BRC. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
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