Journal of Bone and Mineral Research
Papers 9539
1 page of 954 pages (9,539 results)
#1Lingyun Tang (SJTU: Shanghai Jiao Tong University)H-Index: 6
#2Min Wu (Ruijin Hospital)
Last. Zhugang Wang (SJTU: Shanghai Jiao Tong University)H-Index: 30
view all 10 authors...
#1Suzanne M. Jan De Beur (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
#2Paul D. MillerH-Index: 63
Last. Thomas O. Carpenter (Yale University)H-Index: 43
view all 12 authors...
Tumor-induced osteomalacia (TIO) is caused by phosphaturic mesenchymal tumors producing FGF23 and is characterized by impaired phosphate metabolism, skeletal health, and quality of life. UX023T-CL201 is an ongoing, open-label, Phase 2 study investigating safety and efficacy of burosumab, a fully human monoclonal antibody that inhibits FGF23, in adults with TIO or cutaneous skeletal hypophosphatemia syndrome (CSHS). Key endpoints were changes in serum phosphorus and osteomalacia assessed by trans...
#1Marcella D. Walker (Columbia University)H-Index: 23
#2Shonni J. Silverberg (Columbia University)H-Index: 66
#1Kathleen T. Nevola (Tufts University)H-Index: 1
#2Douglas P. Kiel (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 102
Last. Christine W. Lary (Maine Medical Center)H-Index: 3
view all 9 authors...
Osteoporosis is a debilitating and costly disease that causes fractures in 33% of women and 20% of men over the age of 50 years. Recent studies have shown that beta blocker (BB) users have higher bone mineral density (BMD) and decreased risk of fracture compared with non-users. The mechanism underlying this association is thought to be due to suppression of adrenergic signaling in osteoblasts, which leads to increased BMD in rodent models; however, the mechanism in humans is unknown. Also, sever...
#1Zahra Raisi-Estabragh (NIHR: National Institute for Health Research)H-Index: 6
#2Luca Biasiolli (NIHR: National Institute for Health Research)H-Index: 1
Last. Nicholas C Harvey (NIHR: National Institute for Health Research)H-Index: 54
view all 21 authors...
Osteoporosis and ischemic heart disease (IHD) represent important public health problems. Existing research suggests an association between the two conditions beyond that attributable to shared risk factors, with a potentially causal relationship. In this study, we tested the association of bone speed of sound (SOS) from quantitative heel ultrasound with (i) measures of arterial compliance from cardiovascular magnetic resonance (aortic distensibility [AD]); (ii) finger photoplethysmography (arte...
1 CitationsSource
#1Kreepa Kooblall (University of Oxford)H-Index: 4
#2Hannah Boon (University of Oxford)H-Index: 3
Last. Rajesh V. Thakker (University of Oxford)H-Index: 77
view all 13 authors...
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic and pituitary tumors, and is due to mutations in the coding region of the MEN1 gene, which encodes menin. We investigated a family with identical twins that had MEN1, with different MEN1 tumors. DNA sequence analysis of the MEN1 coding region had not identified any abnormalities and we hypothesized that deletions and mutations involving the untranslated regions ...
#1Mariah Farrell (USM: University of Southern Maine)H-Index: 5
#2Heather Fairfield (Tufts University)H-Index: 13
Last. Michaela R. ReaganH-Index: 28
view all 7 authors...
Obesity, a growing pandemic, is a risk factor for many cancers and causes increased bone marrow adipose tissue (BMAT). in vitro studies and obese animal models suggest that BMAT contributes to cancer progression, but there is a lack of preclinical models to directly test BMAT's role in cancer. Overactivation of peroxisome-proliferator-activated receptor-γ (PPARγ) can skew bone formation and resorption rates, resulting in increased BMAT and trabecular bone loss. Thiazolidinediones (eg, rosiglitaz...
1 CitationsSource
#1Amitabh Das (UMB: University of Maryland, Baltimore)H-Index: 11
#2Xiaobei Wang (UMB: University of Maryland, Baltimore)H-Index: 1
Last. Vivek Thumbigere-Math (UMB: University of Maryland, Baltimore)H-Index: 10
view all 13 authors...
Osteoclasts (OCs) are bone-resorbing cells formed by the serial fusion of monocytes. In mice and humans, three distinct subsets of monocytes exist; however, it is unclear if all of them exhibit osteoclastogenic potential. Here we show that in wild-type (WT) mice, Ly6Chi and Ly6Cint monocytes are the primary source of OC formation when compared to Ly6C- monocytes. Their osteoclastogenic potential is dictated by increased expression of signaling receptors and activation of preestablished transcrip...
1 CitationsSource
#1Jack Feehan (University of Melbourne)H-Index: 5
#2Moustapha Kassem (University of Southern Denmark)H-Index: 72
Last. Gustavo Duque (University of Melbourne)H-Index: 39
view all 4 authors...
Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm-like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as ...
#1Kristin M D’Silva (Harvard University)H-Index: 7
#2Sara Jane Cromer (Harvard University)H-Index: 2
Last. Seoyoung C. Kim (Harvard University)H-Index: 36
view all 5 authors...
Zoledronic acid (ZA) is an effective agent in osteoporosis and malignancy-related bone disease but may be associated with increased risk of atrial fibrillation (AF), although current studies disagree on this risk. To examine the risk of incident AF among patients receiving ZA compared with denosumab in the first year of treatment, we performed a new-user, active comparator cohort study including privately insured Americans between January 1, 2010, and June 30, 2019. Individuals aged ≥50 years wi...
1 CitationsSource
Top fields of study
Bone remodeling
Bone mineral
Diabetes mellitus