Primary malignant melanoma of the rectum: report of two cases.

Published on Dec 18, 2012in Case Reports in Surgery
· DOI :10.1155/2012/247348
Kodai Tomioka4
Estimated H-index: 4
(Showa University),
Hitoshi Ojima20
Estimated H-index: 20
+ 5 AuthorsMasahiko Murakami15
Estimated H-index: 15
Sources
Abstract
We report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. They were preoperatively diagnosed with poorly differentiated adenocarcinoma of the rectum. The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. Pathological examination of the resected specimens revealed a malignant melanoma. Immunohistochemical analysis results were positive for HMB-45 and negative for cytokeratin AE1/AE3, CD45, and synaptophysin. Primary anorectal melanoma is an uncommon and aggressive disease that carries a poor prognosis. Therefore, it is necessary to provide systemic treatment. To improve prognosis, it is important to detect anorectal melanoma at an early stage.
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#1Satoshi Ishizone (Shinshu University)H-Index: 12
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Introduction Anorectal malignant melanoma (AMM) is a relatively rare disease. Because of its poor prognosis, the optimal surgical treatment for AMM is still controversial and difficult to determine. In this paper, we report five cases of AMM that have been treated by surgery and/or other methods at Shinshu University Hospital within the last decade. We also review the present five cases along with 74 other Japanese cases reported between 1997 and 2006 and discuss the role of surgery in the treat...
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Malignant melanoma (MM) of the anal region is an uncommon disease. In many cases, the disease is undetected or mistaken for a benign polyp or haemorrhoids until it reaches an advanced state. Owing to delayed diagnosis and early metastases, the prognosis is often poor. In contrast to melanomas of the skin, a history of sun exposure does not seem to have an impact in development of MM in this region. Anorectal melanomas (AM) are most common in the rectum, followed by the anal canal and anal verge....
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Anorectal melanoma is a rare tumor. It has dismal prognosis; only 10% of patients live longer than 5 years. It commonly presents as bleeding from the rectum or as a hemorrhoidal mass. The management of this tumor is controversial. Some authors believe that a palliative local excision is the treatment of choice, whereas others recommend radical surgery in localized disease. We present a retrospective analysis of 72 patients who were managed at our center between 1990 and 2001. This is the largest...
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Absztrakt A mucosalis melanomak csoportjaba tartozo primer gastrointestinalis (GI) melanomak előfordulasa igen ritka. Az osszes malignus melanomat tekintve – azok mintegy 5%-at teszik ki – legnagyobb reszuk (3%) a rectumban talalhato. A prognozis rossz, az atlagos 5 eves tuleles rectalis melanoma eseten 10–20%. Kozlemenyunkben harom esetet mutatunk be. 1. A 68 eves ferfi korszovettanilag igazolt rectummelanoma miatt kerult műtetre. Radikalis műteti es onkologiai kezeles utan a műtetet kovetően h...
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