We report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. They were preoperatively diagnosed with poorly differentiated adenocarcinoma of the rectum. The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. Pathological examination of the resected specimens revealed a malignant melanoma. Immunohistochemical analysis results were positive for HMB-45 and negative for cytokeratin AE1/AE3, CD45, and synaptophysin. Primary anorectal melanoma is an uncommon and aggressive disease that carries a poor prognosis. Therefore, it is necessary to provide systemic treatment. To improve prognosis, it is important to detect anorectal melanoma at an early stage.
PURPOSE: Anal melanoma is rare and associated with a poor outcome. Previous studies that have reported outcomes after surgical treatment are limited by both small number of participants and treatment at single centers only. This study evaluates survival of patients undergoing surgery for anal melanoma from a prospective, population-based database. METHODS: Characteristics and survival of patients undergoing rectal resection or local excision for anal melanoma of the anus, anal canal, and overlap...
Introduction Anorectal malignant melanoma (AMM) is a relatively rare disease. Because of its poor prognosis, the optimal surgical treatment for AMM is still controversial and difficult to determine. In this paper, we report five cases of AMM that have been treated by surgery and/or other methods at Shinshu University Hospital within the last decade. We also review the present five cases along with 74 other Japanese cases reported between 1997 and 2006 and discuss the role of surgery in the treat...
#1J. Heyn(LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2M. Placzek(LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. M. Volkenandt(LMU: Ludwig Maximilian University of Munich)H-Index: 1
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Malignant melanoma (MM) of the anal region is an uncommon disease. In many cases, the disease is undetected or mistaken for a benign polyp or haemorrhoids until it reaches an advanced state. Owing to delayed diagnosis and early metastases, the prognosis is often poor. In contrast to melanomas of the skin, a history of sun exposure does not seem to have an impact in development of MM in this region. Anorectal melanomas (AM) are most common in the rectum, followed by the anal canal and anal verge....
#1Jen Jen Yeh(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 38
#2Jinru Shia(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 94
Last. Martin R. Weiser(MSK: Memorial Sloan Kettering Cancer Center)H-Index: 81
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Objectives: 1) Characterize changes in the surgical treatment of anorectal melanoma over time. 2) Determine if the extent of surgical resection is associated with outcome. 3) Identify prognostic factors correlating with survival. Background Data: Although early data suggested improved survival in patients undergoing abdominoperineal resection (APR) for primary anorectal melanoma, such an aggressive approach may be unwarranted as distant relapse rates are high. We have seen a trend toward less ag...
Last. P. Lasser(Institut Gustave Roussy)H-Index: 37
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Background: This aim of this study was to analyse outcome after surgery for primary anorectal melanoma and to determine factors predictive of survival. Methods: Records of 40 patients treated between 1977 and 2002 were reviewed. Results: Twelve men and 28 women of mean age 58·1 (range 37–83) years were included in the analysis. Overall and disease-free survival rates were 17 and 14 per cent at 5 years. Median overall survival was 17 months and disease-free survival was 10 months. The 5-year surv...
Anorectal melanoma is an uncommon disease. Histologically, the tumor may mimic adenocarcinomas, small cell carcinomas, and sarcomas; grossly, the lesion often mimics hemorrhoids. We report 3 cases of anorectal melanoma: a40-year-old woman with anorectal melanoma with local recurrence after an abdominoperineal resection (APR); a 30-year-old woman with anorectal melanoma and multiple liver metastases returning with multiple masses in the rectum and 2 nodules above and below the left clavicle after...
Abstract Background Anorectal melanoma is a rare but highly lethal malignancy. Historically, radical resection was considered the "gold standard" for treatment of potentially curable anorectal melanoma. The dismal prognosis of this disease has prompted us to recommend wide local excision as the initial therapeutic approach. The purpose of this study was to review our results in patients who underwent wide local excision or radical surgery (abdominoperineal resection [APR]) for localized anorecta...
Anorectal melanoma is a rare tumor. It has dismal prognosis; only 10% of patients live longer than 5 years. It commonly presents as bleeding from the rectum or as a hemorrhoidal mass. The management of this tumor is controversial. Some authors believe that a palliative local excision is the treatment of choice, whereas others recommend radical surgery in localized disease. We present a retrospective analysis of 72 patients who were managed at our center between 1990 and 2001. This is the largest...
: Anorectal melanoma is a rare malignant tumor with approximately 500 cases reported in the literature and has dismal long-term survival prospects. Its poor prognosis is attributable to a delay in diagnosis and its inherent biologic aggressiveness, with many patients presenting with metastatic disease. Endoluminal ultrasound is an established mode of evaluation. The mainstay of treatment is usually surgical with curative or palliative intent. The choice of abdominoperineal resection wide local e...
Anorectal melanoma is a rare malignant tumor with approximately 500 cases reported in the literature and has dismal long-term survival prospects. Its poor prognosis is attributable to a delay in diagnosis and its inherent biologic aggressiveness, with many patients presenting with metastatic disease. Endoluminal ultrasound is an established mode of evaluation. The mainstay of treatment is usually surgical with curative or palliative intent. The choice of abdominoperineal resection vs. wide local...
Targeted therapies for malignant melanoma have improved patients' prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune check...
#2Jagjit Pandey(AIIMS: All India Institute of Medical Sciences)
Last. Hemendra Kumar(AIIMS: All India Institute of Medical Sciences)
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Anorectal melanoma is a rare malignancy with very aggressive course. This case series emphasize the role of imaging, contrast-enhanced computed tomography in evaluating such cases before surgery. CT scan of four patients with pathologically proven primary anorectal malignant melanoma was included. CT findings were analyzed from the picture archiving and communication system for the site of involvement, morphological shape, presence of perirectal and anal infiltration, lymphadenopathy, liver meta...
Malignant gastrointestinal melanoma is usually a metastatic lesion. We report the case of a 67-year-old female patient who presented with intermittent abdominal pain, fever, rigor and diarrhoea. CT scan of the abdomen revealed a large mass at the right iliac fossa with features concerning for intra-abdominal abscess. Exploratory laparotomy confirmed the preoperative diagnosis of abscess, and a right hemicolectomy was performed. Histopathological examination of the surgical specimen was indicativ...
Apregnantwoman in her 30s in the first trimesterwas evaluated for incidentally detected anemia. At colonoscopy, she was found to have a 3 × 4-cm ulceroproliferative lesion in the rectum7 cm from the anal verge. A biopsy specimenwas reported asmoderately differentiatedadenocarcinoma.Noother lesionwasfoundintherestofcolon.Thepregnancywasmedically terminated. Further evaluation showed that the disease was limited to the rectal wall, withnonodal involvement, andtherewasno livermetastasis.Hercarcinoe...
Last. Juan Munoz(UF: University of Florida)H-Index: 7
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Question: A 74-year-old Caucasian woman with a history of persistent hemorrhoids presented with painless intermittent hematochezia per rectum of 6 months’ duration. A thorough physical and digital rectal examination were unremarkable. Laboratory analysis on admission included hemoglobin of 9.9 g/dL and hematocrit of 30.3%. Previous colonoscopy 5 years before admission showed a tubular adenoma. She became symptomatically anemic and underwent a colonoscopy, showing a large rectal fungating mass ex...
Last. Juan Munoz(UF: University of Florida)H-Index: 7
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53-year-old Caucasian woman presented withcomplaints of abdominal pain, constipation,pyrosis, and occasional red blood in her stool for 6months’ duration. The abdominal pain was burning innature, worse with eating, and radiated from her chest toher back. Physical examination was unremarkable anddid not show any pigmentation of the skin or the eyes.Hemoglobin and hematocrit levels on admission were14.3 g/dL and 43.1%, respectively. Colonoscopy showedinternal hemorrhoids and a bi-lobed rectal poly...
Absztrakt A mucosalis melanomak csoportjaba tartozo primer gastrointestinalis (GI) melanomak előfordulasa igen ritka. Az osszes malignus melanomat tekintve – azok mintegy 5%-at teszik ki – legnagyobb reszuk (3%) a rectumban talalhato. A prognozis rossz, az atlagos 5 eves tuleles rectalis melanoma eseten 10–20%. Kozlemenyunkben harom esetet mutatunk be. 1. A 68 eves ferfi korszovettanilag igazolt rectummelanoma miatt kerult műtetre. Radikalis műteti es onkologiai kezeles utan a műtetet kovetően h...