Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3

Background and Purpose Aberrant activation of STAT3 is frequently encountered and promotes proliferation, survival, metastasis and angiogenesis in hepatocellular carcinoma ( HCC ). Here, we have investigated whether emodin mediates its effect through interference with the STAT3 activation pathway in HCC . Experimental Approach The effect of emodin on STAT3 activation, associated protein kinases and apoptosis was investigated using various HCC...