Muthu K. Shanmugam
National University of Singapore
CancerDownregulation and upregulationSTAT proteinKinaseChemistryApoptosisImmunologyIn vivoSTAT3MetastasisAngiogenesisCancer researchCarcinogenesisCell growthSignal transductionMedicineTranscription factorBiologyCancer cellPharmacology
113Publications
47H-index
5,967Citations
Publications 109
Newest
#1Manoj Garg (Amity University)H-Index: 22
#2Muthu K. Shanmugam (NUS: National University of Singapore)H-Index: 47
Last. Gautam Sethi (NUS: National University of Singapore)H-Index: 92
view all 11 authors...
11 CitationsSource
#1Muthu K. Shanmugam (NUS: National University of Singapore)H-Index: 47
#2Manoj Garg (Amity University)H-Index: 22
Last. Anupam Bishyaee (Lake Erie College of Osteopathic Medicine)
view all 7 authors...
BACKGROUND Medicinal plants and herbal preparations in the form of traditional medicines have been used in healthcare worldwide. The extracts of Ginkgo biloba L. seeds and leaves contain a complex mixture of numerous components, such as flavonol glycosides, terpene lactones, and a group of alkylphenols (anacardic or ginkgolic acids, cardanols and cardols) that have been a part of traditional Chinese medicine. These extracts are also sold as dietary supplements worldwide. G. biloba extract (EGb 7...
Source
Source
#1Vikas H. MalojiraoH-Index: 3
Last. Kanchugarakoppal S. Rangappa (University of Mysore)H-Index: 37
view all 14 authors...
Source
#1Jong Hyun Lee (Kyung Hee University)H-Index: 21
#2Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 21
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 12 authors...
: Hepatocellular carcinoma (HCC) is a major malignancy that stands second in terms of global cancer-related mortality. STAT3 has been described as a latent transcription factor that promotes tumorigenesis. This study was designed to examine the effect of vitexin on STAT3 signaling and important hallmarks of cancer. HCC cells were employed to decipher the impact of vitexin on activation of STAT3 signaling using Western blotting, EMSA, immunocytochemistry, and reporter assay. The combinational apo...
13 CitationsSource
#1Dukanya (University of Mysore)H-Index: 2
#2Muthu K. Shanmugam (NUS: National University of Singapore)H-Index: 47
Last. Kanchugarakoppal S. Rangappa (University of Mysore)H-Index: 37
view all 7 authors...
Abstract This data in brief article explains the anti-cancer activity and characterization of oxadiazoles [1] . The main objective of this article was to provide general synthetic procedures, spectral discussion and physical data on the new oxadiazole tethered indazole (OTDs). This article discusses the 1H NMR, 13C NMR, mass spectroscopy, HPLC and melting point of the synthetic compounds. MTT assay used to determine the anti-proliferative activity in hepatocellular cell lines.
Source
#1Dukanya (University of Mysore)H-Index: 2
#2Muthu K. Shanmugam (NUS: National University of Singapore)H-Index: 47
Last. Kanchugarakoppal S. Rangappa (University of Mysore)H-Index: 37
view all 7 authors...
Abstract A novel series of indazole tethered oxadiazoles (OTDs) derivatives were synthesized, characterized, and screened for their anti-proliferative activity against hepatocellular carcinoma (HCC) cells. OTDs structure was further confirmed by Single-crystal X-ray diffraction studies. Among the tested OTDs, compound 2-(4-methoxyphenyl)-5-(1-methyl-1H-indazol-3-yl)-1,3,4-oxadiazole was found to inhibit the catalytical activity of SIRT2 and brings about apoptosis as shown by western blot analysi...
1 CitationsSource
#1Chaithanya Somu (University of Mysore)H-Index: 2
#2Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 21
Last. Kanchugarakoppal S. Rangappa (University of Mysore)H-Index: 37
view all 14 authors...
Abstract Constitutive activation of NF-κB is associated with proinflammatory diseases and suppression of the NF-κB signaling pathway has been considered as an effective therapeutic strategy in the treatment of various cancers including hepatocellular carcinoma (HCC). Herein, we report the synthesis of 1,2 oxazines and their anticancer potential. The antiproliferative studies presented 3-((4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)methyl)-4-phenyl-4,4a,5,6,7,7a-hexahydrocyclopenta [e][1,2]oxazin...
2 CitationsSource
#1Wei Wang (NUS: National University of Singapore)H-Index: 31
#1Wei Wang (NUS: National University of Singapore)H-Index: 68
Last. Deron R. HerrH-Index: 26
view all 15 authors...
Ototoxicity is a major adverse effect of platinum-based chemotherapeutics and currently, there remains a lack of United States Food and Drug Administration-approved therapies to prevent or treat this problem. In our study, we examined the role of the sphingosine 1-phosphate receptor 2 (S1P2) in attenuating cisplatin-induced ototoxicity in several different animal models and cell lines. We found that ototoxicity in S1P2 knockout mice is dependent on reactive oxygen species (ROS) production and th...
10 CitationsSource
#1Chin-Yap Loh (Taylors University)H-Index: 1
#2Jian Yi Chai (Taylors University)H-Index: 1
Last. Chung Yeng Looi (Taylors University)H-Index: 27
view all 8 authors...
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metastasis and chemoresistance in cancer patients. The hallmark of EMT is the upregulation of N-cadherin followed by the downregulation of E-cadherin, and this process is regulated by a complex network of ...
129 CitationsSource