Gautam Sethi
National University of Singapore
CancerSTAT proteinKinaseChemistryApoptosisNF-?BSTAT3MetastasisAngiogenesisCancer researchCarcinogenesisCell growthSignal transductionMedicineProtein kinase BTranscription factorBiologyCell biologyCancer cellPharmacology
Publications 427
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Jeong-Hyeon Ko (Kyung Hee University)H-Index: 13
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 7 authors...
Hypercholesterolemia has been found to be closely linked with a significant increase in both cancer incidence and mortality. However, the exact correlation between serum cholesterol levels and cancer has not been completely deciphered. Here we analyzed the effect of low-density lipoprotein (LDL) cholesterol on prostate and pancreatic cancer cells. We noted that LDL induced a substantial STAT3 activation and JAK1, JAK2, Src activation in diverse prostate and pancreatic tumor cells. Moreover, LDL ...
1 CitationsSource
#1Jiayi Weng (NUS: National University of Singapore)
#2Xiaoqiang Xiang (Fudan University)H-Index: 10
Last. Boon Cher Goh (NUS: National University of Singapore)H-Index: 51
view all 9 authors...
Cancer has risen up to be a major cause of mortality worldwide over the past decades. Despite advancements in cancer screening and diagnostics, a significant number of cancers are still diagnosed at a late stage with poor prognosis. Hence, the discovery of reliable and accurate methods to diagnose cancer early would be of great help in reducing cancer mortality. Extracellular vesicles (EVs) are phospholipid vesicles found in many biofluids and are released by almost all types of cells. In recent...
#1Chakrabhavi Dhananjaya Mohan (University of Mysore)H-Index: 21
#2Shobith RangappaH-Index: 20
Last. Kanchugarakoppal S. Rangappa (University of Mysore)H-Index: 37
view all 8 authors...
Abstract Cancer stands in the frontline among leading killers worldwide and the annual mortality rate is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of cancers and many of them have a small number of approved therapeutic agents. Moreover, several types of major cancers are diagnosed at advanced stages as a result of which the existing therapies have limited efficacy against them and contribute to a dismal prognosis. Therefore, it is essential to develop n...
#1Manoj Garg (Amity University)H-Index: 22
#2Muthu K. Shanmugam (NUS: National University of Singapore)H-Index: 47
Last. Gautam Sethi (NUS: National University of Singapore)H-Index: 92
view all 11 authors...
11 CitationsSource
#1Bahare Salehi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 31
#2Cristina Quispe (Arturo Prat University)H-Index: 14
Last. Javad Sharifi-Rad (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 33
view all 20 authors...
Nigella is a small genus of the family Ranunculaceae, which includes some popular species due to their culinary and medicinal properties, especially in Eastern Europe, Middle East, Western, and Central Asia. Therefore, this review covers the traditional uses and phytochemical composition of Nigella and, in particular, N. sativa. The pharmacological studies reported in vitro, in vivo, and in humans have also been reviewed. One of the main strength of the use of Nigella is that the seeds are rich ...
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2Jae-Young Um (Kyung Hee University)H-Index: 30
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 6 authors...
Abstract Background: Leelamine (LEE) is a lipophilic diterpene amine phytochemical, which can be naturally extracted from pine's bark trees. It has been extensively studied recently for its promising chemopreventive and anti-cancer effects against various cancers such as that of prostate and breast. Hypothesis: We examined the potential impact of LEE in affecting the activation of signal transducer and activator of transcription 3 (STAT3) and promoting apoptosis in human multiple myeloma (MM) ce...
#1Arpita DattaH-Index: 5
#2Shuo DengH-Index: 9
Last. Celestial T. YapH-Index: 21
view all 12 authors...
In cancer cells, a vital cellular process during metastasis is the transformation of epithelial cells towards motile mesenchymal cells called the epithelial to mesenchymal transition (EMT). The cytoskeleton is an active network of three intracellular filaments: actin cytoskeleton, microtubules, and intermediate filaments. These filaments play a central role in the structural design and cell behavior and are necessary for EMT. During EMT, epithelial cells undergo a cellular transformation as mani...
#1Sepideh Mirzaei (IAU: Islamic Azad University, Science and Research Branch, Tehran)H-Index: 1
#2Ali Zarrabi (Sabancı University)H-Index: 16
Last. Gautam Sethi (NUS: National University of Singapore)H-Index: 92
view all 17 authors...
The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential therapeutic target in cancer therapy. It has been well established that transcription factor NF-κB is involved in regulating physiological and pathological events including inflammation, immune response and differentiation. Increasing evidences suggest that deregulated NF-κB signaling can enhance cancer cell proliferation, metastasis and also mediate radio-as well as chemo-resistance. On the contrary, non-coding RNA...
2 CitationsSource
#1Young Yun Jung (Kyung Hee University)H-Index: 6
#2In Jin Ha (Kyung Hee University)H-Index: 1
Last. Kwang Seok Ahn (Kyung Hee University)H-Index: 56
view all 5 authors...
Abstract Introduction The development of cancer generally occurs as a result of various deregulated molecular mechanisms affecting the genes that can control normal cellular growth. Signal transducer and activator of transcription 3 (STAT3) pathway, once aberrantly activated can promote carcinogenesis by regulating the transcription of a number of oncogenic genes. Objectives Here, we evaluated the impact of fangchinoline (FCN) to attenuate tumor growth and survival through modulation of oncogeni...
#1Young Yun JungH-Index: 6
#2Jeong-Hyeon KoH-Index: 13
Last. Kwang Seok AhnH-Index: 56
view all 5 authors...
Purpose: The potential effects of bergamotiin (BGM) on the suppression of cancer cachexia was evaluated under in vitro and in vivo conditions to investigate its possible inhibitory effects on the muscle and fat loss. Method: The differentiated C2C12 and 3T3L1 cells were treated with BGM after the induction of cancer-cachexia with pancreatic cancer conditioned media (CM). The expression levels of the various molecules involved in the differentiation and loss of muscle and fat (MuRF-1, Atrogin-1, ...