British Journal of Pharmacology
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#1Susana Bernal (Complutense University of Madrid)H-Index: 4
#2Laura Lopez-Sanz (Complutense University of Madrid)H-Index: 5
Last. Carmen Gomez-Guerrero (Complutense University of Madrid)H-Index: 34
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Background and purpose Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, oxidative stress, and proteolytic activity in the aortic wall. Targeting Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is a promising strategy for chronic inflammatory diseases. We investigated the vasculoprotective role of suppressor of cytokine signalling-1 (SOCS1), the negative JAK/STAT regulator, in experimental AAA. Experimental approac...
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#1Yanjun Guo (Third Military Medical University)H-Index: 3
Last. Hui Dong (UCSD: University of California, San Diego)H-Index: 27
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BACKGROUND AND PURPOSE Although human blood perfusion is largely redistributed into the mesenteric circulation after meals, the mechanisms by which postprandial nutrients induce mesenteric vasorelaxation, and whether this process is involved in the pathogenesis of colitis are not well understood. We aimed to study the direct actions of nutrients on mesenteric arterial tone and the underlying molecular mechanisms in healthy and colitis mice. EXPERIMENTAL APPROACH We used wire myograph and DSS-ind...
1 CitationsSource
#1Julia A. Tree (PHE: Public Health England)H-Index: 13
#2Jeremy E. Turnbull (UCPH: University of Copenhagen)H-Index: 45
Last. Miles W. Carroll (PHE: Public Health England)H-Index: 26
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BACKGROUND AND PURPOSE: Currently, there are no licensed vaccines and limited antivirals for the treatment of COVID-19. Heparin (delivered systemically) is currently used to treat anticoagulant anomalies in COVID-19 patients. Additionally, in the United Kingdom, Brazil and Australia, nebulised unfractionated heparin (UFH) is being trialled in COVID-19 patients as a potential treatment. A systematic comparison of the potential antiviral effect of various heparin preparations on live wild type SAR...
11 CitationsSource
#1Rhys D.O. Jones (AstraZeneca)H-Index: 10
#2Mike Grondine (AstraZeneca)
Last. Ghada F. Ahmed (AstraZeneca)H-Index: 3
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BACKGROUND AND PURPOSE Savolitinib (AZD6094, HMPL-504, volitinib) is an oral, potent, and highly MET receptor TK inhibitor. This series of studies aimed to develop a pharmacokinetic-pharmacodynamic (PK/PD) model to link inhibition of MET phosphorylation (pMET) by savolitinib with anti-tumour activity. EXPERIMENTAL APPROACH Cell line-derived xenograft (CDX) experiments using human lung cancer (EBC-1) and gastric cancer (MKN-45) cells were conducted in athymic nude mice using a variety of doses an...
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#1Peter Illes (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 58
#2Christa E. Müller (University of Bonn)H-Index: 68
Last. Francesco Di Virgilio (University of Ferrara)H-Index: 74
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The known seven mammalian receptor (R) subunits (P2X1-7) form cationic channels gated by ATP. Three subunits compose a receptor-channel. Each subunit is a polypeptide consisting of two transmembrane regions (TM1, TM2), intracellular N- and C-termini, and a bulky extracellular loop. Crystallization allowed the identification of the 3D-structure and gating cycle of P2XRs. The agonist binding pocket is located at the intersection of two neighboring subunits. In addition to the mammalian P2XRs their...
5 CitationsSource
#1Alireza Tahamtan (Golestan University)H-Index: 10
#2Sjanna B. Besteman (Boston Children's Hospital)H-Index: 2
Last. Vahid Salimi (Tehran University of Medical Sciences)H-Index: 15
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Respiratory syncytial virus (RSV) is an important infectious agent in infants and young children. In most cases, RSV infection only causes mild disease, but in some, it requires invasive ventilation. Although antiviral drugs are obvious candidates to treat viral illness, and some have shown antiviral effects in humans, antivirals such as GS-5806, ALX-0171 and ALS-8176 have not yet met their expectations. Since the inappropriate or dysregulated immune response against RSV leads to harmful immune ...
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#1Ankush Korishettar (MCW: Medical College of Wisconsin)H-Index: 3
#2Yoshinori Nishijima (MCW: Medical College of Wisconsin)H-Index: 5
Last. David X. Zhang (MCW: Medical College of Wisconsin)H-Index: 27
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Background and purpose Vascular transient receptor potential vanilloid (TRPV) channels have emerged as important regulators of vascular tone. TRPV1 and endothelin-1 (ET-1) are independently associated with the pathophysiology of coronary vasospasm but the relationship between their vasomotor functions remains unclear. We characterized the vasomotor function of TRPV1 channels in human arterioles and investigated regulation of their vasomotor function by ET-1. Experimental approach Arterioles were...
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#1Gang Bian (Soochow University (Suzhou))H-Index: 1
#2Lidan Wang (Soochow University (Suzhou))
Last. Yunsen Li (Soochow University (Suzhou))H-Index: 12
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BACKGROUND AND PURPOSE Psoriasis is a chronic immune-mediated inflammatory skin disease that easily recurs and is difficult to cure. DGT is a novel synthetic heterocyclic diterpenoid, whose structure has not been previously reported. We have investigated the action of DGT against psoriasis, specifically the hyperproliferation of epidermal keratinocytes, angiogenesis and pathogenic inflammatory responses. EXPERIMENTAL APPROACH We investigated its pharmacokinetics in skin after topical administrat...
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#1Daiki Ueda (Hoshi University)H-Index: 1
#2Naomi Yonemochi (Hoshi University)H-Index: 3
Last. Hiroko Ikeda (Hoshi University)H-Index: 23
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Background and purpose Patients with diabetes mellitus are reported to show a raised prevalence of mental disorders, which may be reflected in impaired social interaction. However, the mechanisms underlying such impairment in diabetes are unknown. Experimental approach The present study investigated whether social interaction is impaired in diabetic mice and whether central neuropeptide Y (NPY) and glutamatergic function are involved in such impairment. Key results In the three-chamber test, soc...
1 CitationsSource
#1Lisa-Marie Holbrook (University of Reading)H-Index: 8
#2Shirley J. Keeton (University of Reading)H-Index: 3
Last. Daniel R. Kennedy (Western New England University)H-Index: 9
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Background and purpose Multiple members of the thiol isomerase (TI) family of enzymes are present in, and released by platelets. Inhibition of these enzymes results in diminished platelet responses including aggregation, adhesion and thrombus formation. In recent years, the therapeutic potential of TI inhibition has been recognised and drug-development technologies used to identify selective small molecule inhibitors. To date, few pan-TI inhibitors have been characterised and the most studied, b...
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