British Journal of Pharmacology
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#1Lin Gao (NU: Nanjing University)H-Index: 5
#2Xiaowu Dong (Nanjing Medical University)H-Index: 1
Last. Weiqin Li (Nanjing Medical University)H-Index: 25
view all 19 authors...
Background and purpose Pyroptosis is a lytic form of proinflammatory cell death characterised as caspase-1-dependent with canonical NLRP3 inflammasome-induced gasdermin D (GSDMD) activation. We aimed to investigate the role of acinar pyroptotic cell death in pancreatic injury and systemic inflammation in acute pancreatitis (AP). Experimental approach Pancreatic acinar pyroptotic cell death pathway activation upon pancreatic toxin stimulation in vitro and in vivo were investigated. Effects of pha...
1 CitationsSource
#1Boris TchernychevH-Index: 15
#2Huihui Li (Albert Einstein College of Medicine)H-Index: 1
Last. Jaime L. MasferrerH-Index: 30
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BACKGROUND AND PURPOSE Reduced nitric oxide (NO) bioavailability, a hallmark of sickle cell disease (SCD), contributes to intravascular inflammation, vasoconstriction, vaso-occlusion, and organ damage observed in SCD patients. Soluble guanylyl cyclase (sGC) catalyzes synthesis of cyclic guanosine monophosphate (cGMP) in response to NO. cGMP amplifying agents, including NO donors and phosphodiesterase 9 inhibitors, alleviate tumor necrosis factor alpha (TNFα)-induced inflammation in wild-type C57...
#1Fang Zhao (CPU: China Pharmaceutical University)H-Index: 6
#2Shuangyan Wang (CPU: China Pharmaceutical University)H-Index: 2
Last. Zhengyu Cao (CPU: China Pharmaceutical University)H-Index: 16
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BACKGROUND AND PURPOSE Cocamide monoethanolamide (CMEA) is commonly used as a surfactant-foam booster in cosmetic formulations. Upon contact with the eye or other sensitive skin areas, CMEA elicits sting and lasting irritation. We hypothesized a specific molecular interaction with TRPV1 by which CMEA caused eye irritation. EXPERIMENTAL APPROACH Eye irritancy is evaluated using eye-wiping test in rabbit and mouse. Intracellular Ca2+ concentrations and action potentials are measured using Ca2+ ima...
#1Xiaoyun Zhu (CPU: China Pharmaceutical University)H-Index: 3
#2Shengtao Ye (CPU: China Pharmaceutical University)H-Index: 1
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Background and purpose Liver fibrosis is one of the leading causes of morbidity and mortality worldwide of which no acceptable therapy exists. Accumulating evidence supports that glioma-associated oncogene homologue 1 (GLI1) is a potentially important therapeutic target for liver fibrosis. This study investigates the antifibrotic activities and potential mechanisms of Physalin B (PB), a natural Solanaceae compound. Experimental approach Mice subjected to carbon tetrachloride (CCl4 ) challenge an...
1 CitationsSource
#1Coralie Mergault (François Rabelais University)
#2Fanny Lisée (François Rabelais University)
Last. Sylvain Marchand-Adam (François Rabelais University)H-Index: 20
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BACKGROUND AND PURPOSE The Arp2/3 multiprotein complex regulates branched polymerisation of the actin cytoskeleton, and may contribute to collagen synthesis and fibrogenesis in the lung. EXPERIMENTAL APPROACH Expression of Arp2/3 components was assessed in human lung fibroblasts and in the bleomycin-induced pulmonary fibrosis model in mice. The Arp2/3 complex was repressed with the allosteric inhibitor CK666 and with interfering RNAs targeting the ARP2, ARP3 and ARPC2 subunits (siARP2, siARP3, s...
#1Jessica Conway (University of Birmingham)
#2Michelangelo Certo (University of Birmingham)H-Index: 12
Last. Niharika A. Duggal (University of Birmingham)H-Index: 12
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Advancing age is accompanied by significant remodelling of the immune system, termed immunesenescence, and increased systemic inflammation, termed inflammaging, both of which contribute towards an increased risk of developing chronic diseases in old age. Age-associated alterations in metabolic homeostasis have been linked with changes in a range of physiological functions, but their impact on immunesenescence remains poorly understood. In this article, we review the recent literature to formulat...
#1Juliana Fabiana Gregório (NIST: National Institute of Standards and Technology)H-Index: 3
Last. Giselle Santos Magalhães (NIST: National Institute of Standards and Technology)H-Index: 7
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The incidence of asthma is a global health problem and requires studies aimed for the development of new treatments to improve its clinical management, reducing personal and economic burdens on the health system. Therefore, the discovery of mediators that promote anti-inflammatory and pro-resolutive effects are highly desirable to improve lung function and quality of life of asthmatic patients. In that regard, experimental studies have shown that the angiotensin-(1-7)/Mas receptor (MAS1) of the ...
#1Li-Ping Jiang (Nanjing Medical University)H-Index: 1
#2Jin-Zi Ji (Nanjing Medical University)H-Index: 4
Last. Hong-Guang Xie (Nanjing Medical University)H-Index: 3
view all 8 authors...
Background and purpose null Overweight or obese patients exhibit poorer platelet responses to clopidogrel; however, the mechanisms behind this phenotype remain to be elucidated. Here, we sought to dissect whether and why obesity could affect the metabolic activation of and/or platelet response to clopidogrel in obese patients and high-fat diet-induced obese mice. null Experimental approach null A post hoc stratified analysis of an observational clinical study was performed to investigate changes...
#1Germana CocozzaH-Index: 4
#2Stefano Garofalo (Sapienza University of Rome)H-Index: 8
Last. Massimo Federici (University of Rome Tor Vergata)H-Index: 70
view all 13 authors...
BACKGROUND AND PURPOSE Patients with amyotrophic lateral sclerosis (ALS) exhibit dysfunctional energy metabolism and weight loss, which is negatively correlated with survival, together with neuroinflammation. However, the possible contribution of neuroinflammation to deregulations of feeding behaviour of ALS has not been studied in detail. We here investigated if microglial KCa3.1 is linked to hypothalamic neuroinflammation and affects feeding behaviours in ALS mouse models. EXPERIMENTAL APPROAC...
#1Scott P. Fraser (Imperial College London)H-Index: 28
#2Rustem Onkal (Imperial College London)H-Index: 6
Last. Mustafa B.A. Djamgoz (Imperial College London)H-Index: 55
view all 5 authors...
Background and purpose null Voltage-gated sodium (NaV ) channels are expressed de novo in carcinomas where their activity promotes invasiveness. Breast and colon cancer cells express the neonatal splice variant of NaV 1.5 (nNaV 1.5) which has several amino acid substitutions in the domain I voltage-sensor compared to its adult counterpart (aNaV 1.5). This study aimed to determine whether nNaV 1.5 could be distinguished pharmacologically from aNaV 1.5. null Experimental approach null Cells expres...
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