British Journal of Pharmacology
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#1Rita Costa (LMU: Ludwig Maximilian University of Munich)H-Index: 9
#2Darcy E. Wagner (LMU: Ludwig Maximilian University of Munich)H-Index: 23
Last. Melanie Königshoff (LMU: Ludwig Maximilian University of Munich)H-Index: 44
view all 14 authors...
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#1Jordan T. Bateman (UF: University of Florida)H-Index: 2
#2Sandy E. Saunders (UF: University of Florida)H-Index: 1
Last. Erica S. Levitt (UF: University of Florida)H-Index: 10
view all 3 authors...
Respiratory depression is the proximal cause of death in opioid overdose, yet the mechanisms underlying this potentially fatal outcome are not well understood. The goal of this review is to provide a comprehensive understanding of the pharmacological mechanisms of opioid-induced respiratory depression, which could lead to improved therapeutic options to counter opioid overdose, as well as other detrimental effects of opioids on breathing. The development of tolerance in the respiratory system is...
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Emerging data shows pregnant women with COVID-19 are at significantly higher risk of severe outcomes compared to non-pregnant women of similar age. This review discusses the invaluable insight revealed from vaccine clinical trials in women who were vaccinated and inadvertently became pregnant during the trial period. It further explores a number of clinical avenues in their management and proposes a drug development strategy in-line with clinical trials for vaccines and drug treatments for the d...
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#1Mei Yang (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Qishan Chen (QMUL: Queen Mary University of London)H-Index: 15
Last. Li Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
view all 12 authors...
BACKGROUND AND PURPOSE Neointimal hyperplasia (NIH) is the fundamental cause for vascular diseases, and vascular smooth muscle cell (VSMC) dysregulation has been widely implicated in NIH. Neutrophil elastase (NE) has been suggested as potential therapeutic for multiple diseases. Here we investigated the role of NE in VSMC functions and injury-induced NIH, and further explored the therapeutic potential of targeting NE in NIH. EXPERIMENTAL APPROACH VSMCs were used to analyze the effects of NE on V...
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#1Michael L Garelja (University of Otago)
#2Christopher S Walker (University of Auckland)H-Index: 17
Last. Debbie L. Hay (University of Otago)H-Index: 42
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The development of several drugs that target the calcitonin gene-related peptide (CGRP) system has been a major breakthrough in the pharmacological management of migraine. These are divided into two major classes: antibodies which bind to the CGRP peptide, preventing it from activating CGRP receptors and receptor antagonists. Within the receptor antagonist class, there are two mechanisms of action: small molecule receptor antagonists and an antibody antagonist. This mini-review considers the pha...
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#1Louise F. KimuraH-Index: 1
#2Leonardo S. Novaes (USP: University of São Paulo)H-Index: 5
Last. Rosana Camarini (USP: University of São Paulo)H-Index: 26
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Depression and anxiety commonly occur in chronic pain states, and the co-existence of these diseases worsen outcomes for both disorders and may reduce treatment adherence and response. Despite the advances in the knowledge of chronic pain mechanisms, pharmacological treatment is still unsatisfactory. Research based on exposure to environmental enrichment (EE) is currently under investigation and seems to offer a promising low-cost strategy with no side effects. In this review, we discuss the rol...
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#1Toshiyuki Nishikido (Imperial College London)H-Index: 2
#2Kausik K. Ray (Imperial College London)H-Index: 42
: LDL cholesterol (LDL-C) plays a central role in the progression of atherosclerosis. Statin therapy for lowering LDL-C reduces the risk of atherosclerotic cardiovascular disease and is the recommended first-line treatment for patients with high LDL-C levels. However, some patients are unable to achieve an adequate reduction in LDL-C with statins or are statin-intolerant; thus, PCSK9 inhibitors were developed to reduce LDL-C levels, instead of statin therapy. PCSK9 monoclonal antibodies dramatic...
2 CitationsSource
#1Marwa Daghem (BHF: British Heart Foundation)H-Index: 4
#2David E. Newby (BHF: British Heart Foundation)H-Index: 105
: Advances in imaging technology have driven the rapid expansion in the use of computed tomography in the assessment of coronary atherosclerotic plaque. Current guidelines recommend coronary CT angiography as the first line diagnostic test for patients presenting with stable chest pain based on a rapidly growing evidence base. There is a growing need to refine current methods for diagnosis and risk stratification to better individualise preventative therapies. Imaging assessments of high-risk pl...
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#1Feng Zhang (Nanjing University of Chinese Medicine)H-Index: 25
#2Feixia Wang (Nanjing University of Chinese Medicine)H-Index: 8
Last. Shizhong Zheng (Nanjing University of Chinese Medicine)H-Index: 28
view all 12 authors...
BACKGROUND AND PURPOSE Portal hypertension is a lethal complication of cirrhosis. Its mechanism and therapeutic targets remain largely unknown. Hepatic stellate cell (HSC) contraction increases intrahepatic vascular resistance contributing to portal hypertension. We investigated how HSC contraction was regulated by Wnt signaling and the therapeutic implication. EXPERIMENTAL APPROACH Liver tissues from cirrhotic patients were examined. Cirrhotic mice with genetic or pharmacological treatments wer...
2 CitationsSource
#1Rouchelle Sriranjan (University of Cambridge)H-Index: 3
#2Jason M. Tarkin (University of Cambridge)H-Index: 15
Last. James H. F. Rudd (University of Cambridge)H-Index: 2
view all 6 authors...
: PET imaging is able to harness biological processes to characterise high-risk features of atherosclerotic plaque prone to rupture. Current radiotracers are able to track inflammation, microcalcification, hypoxia, and neoangiogenesis within vulnerable plaque. 18 F-fluorodeoxyglucose (18 F-FDG) is the most commonly used radiotracer in vascular studies and is employed as a surrogate marker of plaque inflammation. Increasingly, 18 F-FDG and other PET tracers are also being used to provide imaging ...
4 CitationsSource
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