Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models

Brandon Carney; Giuseppe Carlucci; Beatriz Salinas; Valentina Di Gialleonardo; Susanne Kossatz; Axel Vansteene; Valerie A. Longo; Alexander Bolaender; Gabriela Chiosis; Kayvan R. Keshari; Thomas Reiner

doi:https://doi.org/10.1007/s11307-015-0904-y

doi.org/10.1007/s11307-015-0904-y

Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models

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..., Thomas Reiner

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Molecular Imaging and Biology3.10

Volume: 18, Issue: 3, Pages: 386 - 392

Published: Oct 22, 2015

Abstract

The current study presents [(18)F]PARPi as imaging agent for PARP1 expression.[(18)F]PARPi was generated by conjugating a 2H-phthalazin-1-one scaffold to 4-[(18)F]fluorobenzoic acid. Biochemical assays, optical in vivo competition, biodistribution analysis, positron emission tomography (PET)/X-ray computed tomography, and PET/magnetic resonance imaging studies were performed in subcutaneous and orthotopic mouse models of...

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Paper Details

Title

Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models

DOI

doi.org/10.1007/s11307-015-0904-y

Published Date

Oct 22, 2015

Journal

Molecular Imaging and Biology

Volume

18

Issue

3

Pages

386 - 392

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