Giuseppe Carlucci
New York University
AnalytePharmacokineticsAnalytical chemistryDetection limitHigh-performance liquid chromatographyChemistryIn vivoCalibration curveSample preparationUrineAnthraquinonesAntibacterial agentChromatographyReversed-phase chromatographyExtraction (chemistry)BotanyMedicineElutionSolid phase extractionBiologyQuantitative analysis (chemistry)
129Publications
27H-index
2,305Citations
Publications 128
Newest
#1Peter Panizzi (AU: Auburn University)H-Index: 25
#2Marvin Krohn-Grimberghe (Harvard University)H-Index: 1
Last. Matthias Nahrendorf (Harvard University)H-Index: 102
view all 34 authors...
Acute bacterial endocarditis is a rapid, difficult to manage, and frequently lethal disease. Potent antibiotics often cannot efficiently kill Staphylococcus aureus that colonizes the heart’s valves. S. aureus relies on virulence factors to evade therapeutics and the host’s immune response, usurping the host’s clotting system by activating circulating prothrombin with staphylocoagulase and von Willebrand factor–binding protein. An insoluble fibrin barrier then forms around the bacterial colony, s...
Source
#1Jiacheng Wang (NYU: New York University)
#2Michael MacLean (NYU: New York University)H-Index: 4
Last. Yu-Shin Ding (NYU: New York University)H-Index: 13
view all 10 authors...
212 Objectives: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by selective degeneration of both upper and lower motor neurons, resulting in paralysis of skeletal muscle and respiratory failure, with death occurring within 2-5 years of diagnosis. 90% of cases are sporadic, and of the 10% that are familial more than 20 genes (>150 mutations) have been found to be associated with ALS, most notably copper/zinc superoxide dismutase (SOD1). SOD1 mutant...
#1Alina Diuzheva (CULS: Czech University of Life Sciences Prague)H-Index: 10
#2Marcello LocatelliH-Index: 36
Last. Vasil AndruchH-Index: 26
view all 7 authors...
INTRODUCTION: The analysis of plant and herbal samples is a challenging task for analytical chemists due to the complexity of the matrix combined with the low concentration of analytes. In recent years different liquid-phase microextraction (LPME) techniques coupled with a variety of analytical equipment have been developed for the determination of both organic and inorganic analytes. OBJECTIVE: Over the past few years, the number of research papers in this field has shown a markedly growing ten...
4 CitationsSource
#1Nicholas Ramos (NYU: New York University)H-Index: 7
#2Jairo Baquero-Buitrago (NYU: New York University)H-Index: 2
Last. Giuseppe Carlucci (NYU: New York University)H-Index: 27
view all 7 authors...
: The cell cycle is a progression of four distinct phases (G1, S, G2, M), with various cycle proteins being essential in regulating this process. In breast cancer, alterations in the cell cycle and uncontrolled proliferation led to several studies interrogating the relationship between cyclins and their counterpart cyclin-dependent-kinases (CDKs). We aimed to develop a radiolabeled CDK4/6 inhibitor for breast cancer imaging. Our transfluorinated analog ([18F]-CDKi) was evaluated and validated as...
4 CitationsSource
#1Vincenzo FerroneH-Index: 11
#2Sabrina TodaroH-Index: 1
Last. Edoardo Milanetti (IIT: Istituto Italiano di Tecnologia)H-Index: 9
view all 7 authors...
Abstract In this paper a dispersive magnetic-solid phase extraction (MSPE) using a graphene nanocomposite (rG/Fe3O4 ) followed by ultra high performance liquid chromatography with photodiode array detection has been developed for the simultaneous analysis of new class of oral anticoagulants (NOAs) in human plasma. The performance of the nanocomposite graphene@Fe3O4 on the magnetic solid phase extraction of apixaban, rivaroxaban and dabigatran has been optimized using a Box-Behnken design of expe...
9 CitationsSource
#1Edoardo Milanetti (IIT: Istituto Italiano di Tecnologia)H-Index: 9
#2Giuseppe CarlucciH-Index: 27
Last. Vincenzo FerroneH-Index: 11
view all 6 authors...
Abstract In the present work we analyzed the hydrophobicity and hydrophilicity properties of several non-steroidal anti-inflammatory drugs (NSAIDs) by investigating the structural changes of the dynamic hydrogen bond network in order to predict the extraction recovery of NSAIDs from biological fluids set by solid phase extraction (SPE). This work allows investigating the relationship between theoretical descriptors and experimental data using a parameter free method with a strong correlation (Pe...
7 CitationsSource
#1Max L. SendersH-Index: 11
#2Sophie Hernot (Vrije Universiteit Brussel)H-Index: 21
Last. Carlos Pérez-Medina (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 21
view all 28 authors...
Abstract Objectives This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque phenotyping, facilitated by clinically approved and nanobody radiotracers. Background Noninvasive characterization of atherosclerosis remains a challenge in clinical practice. The limitations of current diagnostic methods demonstrate that, in addition to atherosclerotic plaque morphology and composition, disease act...
34 CitationsSource
#1Tina Binderup (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 24
#2Raphaël Duivenvoorden (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 25
Last. Willem J. M. MulderH-Index: 73
view all 32 authors...
Nanomedicine research produces hundreds of studies every year, yet very few formulations have been approved for clinical use. This is due in part to a reliance on murine studies, which have limited value in accurately predicting translational efficacy in larger animal models and humans. Here, we report the scale-up of a nanoimmunotherapy from mouse to large rabbit and porcine atherosclerosis models, with an emphasis on the solutions we implemented to overcome production and evaluation challenges...
25 CitationsSource
#1Nicholas Ramos (NYU: New York University)H-Index: 7
#2Jairo Baquero-Buitrago (NYU: New York University)H-Index: 2
Last. Giuseppe Carlucci (NYU: New York University)H-Index: 27
view all 5 authors...
1036 Introduction: Breast cancer is a worldwide health issue with about 1 million new cases every year. Dysregulated cellular proliferation, a common feature to all human cancers, is a key player of aberrant proliferative signaling and is therefore considered as a “hallmark of cancer”. In breast cancer, a lot of attention focuses on particular members of the cell cycle machinery, the D-type cyclins and their partner cyclin-D kinases 4 and 6 (CDK4/6). CDKs are serine/threonine kinases key in regu...
#1Yu-Shin Ding (NYU: New York University)H-Index: 25
#1Yu-Shin Ding (NYU: New York University)H-Index: 69
Last. James A. Ciaccio (Fordham University)H-Index: 6
view all 8 authors...
1105 Objectives: There is an urgent need for the development of Parkinson9s disease (PD) treatments that can slow disease progression. LRRK2 (leucine-rich repeat kinase 2) has recently been identified as a causative gene for autosomal dominant Parkinson’s disease (PD), with LRRK2 mutation G2019S linked to the most frequent familial form of PD. Several LRRK2 inhibitors have been developed and evaluated in vitro; however, in vivo target engagement has never been characterized. Despite research eff...
1 Citations