Molecular Imaging and Biology
Papers 1,962
1 page of 197 pages (1,962 results)
#1Zhongqian Hu (SEU: Southeast University)
#2Sunitha V. Bachawal (Stanford University)H-Index: 21
Last. Ramasamy Paulmurugan (Stanford University)H-Index: 46
view all 7 authors...
Purpose null Accurate identification and assessment of sentinel lymph node (SLN) using noninvasive imaging methods can play a vital role in tumor staging, surgical planning, and prognostic evaluation. In this study, we assessed the efficacy of B7-H3-targeted molecular-ultrasound imaging for the early SLN detection, and characterization in a mouse model of orthotopic breast cancer. null Procedures null We established a mouse breast cancer model with lymph node metastasis by injecting MAD-MB 231 c...
#1Veronica P Dubois (UWO: University of Western Ontario)H-Index: 3
#2Olivia C. Sehl (UWO: University of Western Ontario)H-Index: 3
Last. John A. Ronald (UWO: University of Western Ontario)H-Index: 4
view all 4 authors...
Chimeric antigen receptor (CAR) T cell cancer immunotherapies have shown remarkable results in patients with hematological malignancies and represent the first approved genetically modified cellular therapies. However, not all blood cancer patients respond favorably, serious side effects have been reported, and the treatment of solid tumors has been a challenge. An imaging tool for visualizing the variety of CAR-T cell products in use and being explored could provide important patient-specific d...
#1Jonathan S. Wall (UT: University of Tennessee)H-Index: 33
#2Emily B. Martin (UT: University of Tennessee)H-Index: 10
Last. Stephen J. Kennel (UT: University of Tennessee)H-Index: 57
view all 13 authors...
Purpose null Accurate diagnosis of amyloidosis remains a significant clinical challenge and unmet need for patients. The amyloid-reactive peptide p5+14 radiolabeled with iodine-124 has been developed for the detection of amyloid by PET/CT imaging. In a first-in-human evaluation, the dosimetry and tissue distribution of 124I-p5+14 peptide in patients with systemic amyloidosis. Herein, we report the dosimetry and dynamic distribution in the first three enrolled patients with light chain-associated...
#2Jens Kurth (University of Rostock)H-Index: 8
#1Seung Jin Lee (Chonnam National University)H-Index: 5
#2Ilwoo Park (Chonnam National University)H-Index: 21
Last. Jeremy W. Gordon (UCSF: University of California, San Francisco)H-Index: 19
view all 4 authors...
PURPOSE This study examined the feasibility of using two novel agents, hyperpolarized [13C]t-butanol and [13C,15N2]urea, for assessing in vivo perfusion of the intact spinal cord in rodents. Due to their distinct permeabilities to blood brain barrier (BBB), we hypothesized that [13C]t-butanol and [13C,15N2]urea exhibit unique 13C signal characteristics in the spinal cord. PROCEDURES Dynamic 13C t-butanol MRI data were acquired from healthy Long-Evans rats using a symmetric, ramp-sampled, partial...
#1Vytautas Kucikas (University of Limoges)
#2Maximilian P Werner (RWTH Aachen University)
Last. Marc A. M. J. van Zandvoort (RWTH Aachen University)H-Index: 41
view all 5 authors...
In recent years, the demand for non-destructive deep-tissue imaging modalities has led to interest in multiphoton endoscopy. In contrast to bench top systems, multiphoton endoscopy enables subcellular resolution imaging in areas not reachable before. Several groups have recently presented their development towards the goal of producing user friendly plug and play system, which could be used in biological research and, potentially, clinical applications. We first present the technological challen...
#1Amanda J. Boyle (CAMH: Centre for Addiction and Mental Health)H-Index: 10
#2Andrea Narvaez (CAMH: Centre for Addiction and Mental Health)
Last. Neil Vasdev (U of T: University of Toronto)H-Index: 34
view all 7 authors...
Cyclooxygenase-2 (COX-2) is a target for inflammation and colorectal cancer (CRC). This study evaluated the COX-2 neuro-PET radiopharmaceutical, [11C]MC1, in CRC xenograft mice. [11C]MC1 was evaluated in ICRscid mice with HT-29 and HCT-116 CRC xenografts, with high and low COX-2 expression, respectively, by immunohistochemistry, cellular uptake, dynamic PET/MR imaging, ex vivo biodistribution, and radiometabolite analysis. HT-29 xenografts were well visualized with [11C]MC1 using PET/MR. Time-ac...
#1Marcelo Queiroz (USP: University of São Paulo)H-Index: 13
#2Cinthia D. Ortega (USP: University of São Paulo)H-Index: 8
Last. Carlos Alberto Buchpiguel (USP: University of São Paulo)H-Index: 32
view all 7 authors...
To analyze the associations between positron emission tomography (PET)/magnetic resonance imaging (MRI) features for primary rectal tumors and metastases. Between November 2016 and April 2018, 101 patients with rectal adenocarcinoma were included in this prospective study (NCT02537340) for whole-body PET/MRI for baseline staging. Two readers analyzed the PET/MRI; they assessed the semiquantitative PET features of the primary tumor and the N- and M-stages. Another reader analyzed the MRI features...
#1Sonja Schelhaas (WWU: University of Münster)H-Index: 12
#2Lynn J. Frohwein (WWU: University of Münster)H-Index: 4
Last. Andreas H. Jacobs (WWU: University of Münster)H-Index: 57
view all 7 authors...
PURPOSE Multimodal molecular imaging allows a direct coregistration of different images, facilitating analysis of the spatial relation of various imaging parameters. Here, we further explored the relation of proliferation, as measured by [18F]FLT PET, and water diffusion, as an indicator of cellular density and cell death, as measured by diffusion-weighted (DW) MRI, in preclinical tumor models. We expected these parameters to be negatively related, as highly proliferative tissue should have a hi...
#1Lisa Honold (WWU: University of Münster)H-Index: 9
Last. Sven Hermann (WWU: University of Münster)H-Index: 31
view all 11 authors...
Dysregulated activity of matrix metalloproteinases (MMPs) drives a variety of pathophysiological conditions. Non-invasive imaging of MMP activity in vivo promises diagnostic and prognostic value. However, current targeting strategies by small molecules are typically limited with respect to the bioavailability of the labeled MMP binders in vivo. To this end, we here introduce and compare three chemical modifications of a recently developed barbiturate-based radiotracer with respect to bioavailabi...
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