Effects of HIV and combination antiretroviral therapy on cortico-striatal functional connectivity

Objective: Determine whether HIV and combination antiretroviral therapy (cART) affect resting-state functional connectivity (rs-fc) between the striatum and the cortical regions. Methods: Forty-nine HIV-uninfected (HIV−) and 132 HIV-infected (HIV+) (65% receiving cART) patients underwent laboratory studies (current and nadir CD4+ T-cell counts, and plasma HIV viral load), neuropsychological performance testing, and neuroimaging. Rs-fc, which...