Welche Methoden zur Minimierung des Zeitfaktors sind gesichert, welche sind ungesichert?

Published on Oct 1, 2000in Strahlentherapie Und Onkologie3.621
· DOI :10.1007/PL00002313
Klaus-Rüdiger Trott11
Estimated H-index: 11
(QMUL: Queen Mary University of London),
Michael Baumann68
Estimated H-index: 68
(TUD: Dresden University of Technology)
Eine Reihe experimenteller Untersuchungen und randomisierter klinischer Studien zeigen eine Abnahme der lokalen Tumorkontrolle mit zunehmender Gesamtbehandlungszeit einer fraktionierten Strahlentherapie. Die wahrscheinlichste Ursache dises Zeitfaktors ist die Proliferation klonogener Tumorzellen wahrend der Therapie. Durch eine gezielte Hemmung der Proliferation klonogener Zellen wahrend einer Strahlenbehandlung konnten daher moglicherweise wesentliche Fortschritte in der Radioonkologie erreicht werden.
#1Cordula PetersenH-Index: 35
#2Michael Baumann (TUD: Dresden University of Technology)H-Index: 68
Eine Reihe experimenteller und prospektiv randomisierter Studien zeigt, dass die Chance der lokalen Tumorvernichtung mit zunehmender Gesamtbehandlungszeit einer fraktionierten Strahlentherapie vermindert werden kann.
Der Einfluss des Intervalls zwischen Operation und Bestrahlung, insbesondere in Kombination mit Chemotherapie, auf die lokoregionare Prognose ist in den letzten Jahren zunehmend in den Blickpunkt geruckt.
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Zur Beantwortung der Frage nach dem Effekt der Gesamtbehandlungszeit der Strahlentherapie auf das Therapieergebnis bei verschiedenen Tumorentitaten wurden die randomisierten Studien zur akzelierten Fraktionierung vergleichend in einer Ubersicht dargestellt. Es wurden nur Studien aufgenommen, bei denen die Strahlentherapie die definitive lokoregionale Therapie war.
Hintergrund Die strahlenbiologischen Mechanismen, die bei der Planung neuer Strategien der Radiochemotherapie therapeutisch ausgenutzt werden konnen, werden dargestellt.
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PURPOSEInduction chemotherapy for advanced head and neck (H&N) cancer has been studied in clinical trials for more than two decades without clear demonstration of benefit for locoregional tumor control or overall patient survival. Nonetheless, its use has become a common community standard of practice in the United States (US). This report examines some of the factors that may have contributed to this phenomenon.MATERIALS AND METHODSA mail survey was conducted of 300 US community cancer speciali...
This chapter provides an overview of the tumor stem cells. There is a characteristic difference between the concept of stem cells in tumors and stem cells in normal tissues. In tumors, stem cells may be defined as the biological units which have the potential of giving rise to a new tumor, either by metastasis or by tumor recurrence after therapy. This definition provides a much more rigorous test for identifying stem cells than is available in most normal tissues except for the bone marrow stem...
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#2G AndersonH-Index: 1
Last. O BrodinH-Index: 1
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Last. Lester J. Peters (University of Texas MD Anderson Cancer Center)H-Index: 75
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Abstract Experiments were performed to establish the extent and kinetics of tumor cell repopulation in a murine sarcoma, designated SA-NH, treated with cyclophosphamide (CY). Mice bearing 8-mm leg tumors were treated with 200 mg/kg CY which caused a transient tumor regression. Changes in the absolute clonogen content of tumors was determined by the change in TCD 50 values (50% tumor control) obtained under hypoxic conditions of local tumor irradiation at different times after CY treatment until ...
#1Jennifer R. Grandis (University of Pittsburgh)H-Index: 96
#2David J. TweardyH-Index: 49
Abstract The squamous mucosa of patients who develop head and neck cancer is “condemned” or predisposed to disregulated growth as reflected by the high incidence of synchronous and metachronous primary tumors. We hypothesized that transformed and nontransformed mucosa from head and neck cancer patients would produce increased levels of transforming growth factor α (TGF-α) and its cell surface receptor, the epidermal growth factor receptor (EGFR), thereby contributing to this predisposition. Usin...
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Il fine ultimo della radioterapia (RT) e l’eradicazione della totalita delle cellule tumorali clonogeniche (cellule staminali), con contenimento del danno ai tessuti irradiati entro livelli accettabili. A tale scopo le recenti innovazioni nell’ambito delle tecniche di radioterapia si sono tradotte in un miglioramento nella selezione e nel contornamento dei volumi di interesse e nella messa a punto di piani di trattamento per l’ottimizzazione del calcolo delle dosi. Inoltre, si e aggiunta la disp...
#1Elizabeth Murray (UCT: University of Cape Town)H-Index: 16
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Last. Gerald Langman (UCT: University of Cape Town)H-Index: 4
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Background and Purpose: By virtue of their high linear energy transfer (LET) characteristics the biologic effectiveness of neutrons is less dependent on tissue oxygenation tension and cell cycle phase as compared to that with photons. Hence, an improved clinical benefit is to be expected predominantly in large, hypoxic and slowly growing tumors. Since a short course of radiotherapy is required for clinical reasons, it prompted the authors to initiate a randomly controlled trial on locally advanc...
#1Anja Bollmann (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 1
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Background and Purpose: Up to now, evidence about survival of patients with non-small-cell lung cancer treated with radiation therapy alone is only available from clinical studies. The authors analyzed survival experiencedepending on several prognostic factors from a population-based cancer registry and compared this to survival data from the literature. Patients and Methods: Between April 1996 and September 1999, 1,696 patients with lung cancer were recruited by the Halle Lung Cancer (HALLUCA) ...
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In der vorliegenden Untersuchung wurde die Effizienz einer akzeleriert fraktionierten Bestrahlung im Vergleich zu einer konventionell fraktionierten Bestrahlung zur lokalen Tumorkontrolle zweier humaner Plattenepithelkarzinome am Heterotransplantatmodell “nu/nu”-Maus untersucht.
Die aktuelle Ausstattung der strahlentherapeutischen Einrichtungen mit arztlichem Personal wird hinsichtlich verschiedener Einflussgrosen analysiert.
Die perkutane Strahlentherapie ist neben den unterschiedlichen chirurgischen Ansatzen der zervikalen Lymphknotenausraumung die wichigste onkologische Modalitat in der Behandlung zervikaler Lymphknotenmetastasen. Der Einsatz einer Radiotherapie wird wesentlich durch den Primartumor, seine Ausdehnung und Lokalisation, Zelltyp und Vorliegen regionarer Lymphknotenmetastasen wie auch Art und Ausmas der vorangegangenen oder geplanten chirurgischen Intervention bestimmt.
#1Jörg O. Zieron (UHH: University of Hamburg)H-Index: 3
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Last. Hans-Peter Beck-Bornholdt (UHH: University of Hamburg)H-Index: 17
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Gaps are a common feature of clinical radiotherapy. Only little information is available about the influence of the position of a gap on tumor response.
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