Klaus-Rüdiger Trott
University of London
OffspringCancerRadiobiologyInternal medicineRadiologyPathologyOncologyCellPediatricsMedical physicsRadiation treatment planningImmunologyYoung adultProstateEndometrial cancerCarcinomaPelvisThyroid cancerBone marrowProstate cancerDose-volume histogramHypoplasiaRadiation oncologistRectumStem cellHereditary DiseasesGynecologyRadiation doseNuclear medicineSplit courseDose distributionCancer researchRadiation therapyCell growthBirth weightMedicineBiology
26Publications
11H-index
717Citations
Publications 25
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#1Wolfgang DörrH-Index: 38
#2Thomas HerrmannH-Index: 21
Last. Klaus-Rüdiger TrottH-Index: 11
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Effects of radiation exposure are observed in virtually all normal tissues. Early reactions occur primarily in turnover tissues (e.g., bone marrow, epidermis, mucosae of the gastrointestinal tract), where proliferative impairment results in progressive hypoplasia and eventually complete loss of functional cells, after a tissue dependent but dose independent latent time. These early radiation reponses are regularly preceded and accompanied by vascular and inflammatory reactions. In contrast, late...
3 CitationsSource
#2Catharine H. Clark (The Royal Marsden NHS Foundation Trust)H-Index: 26
Last. Klaus-Rüdiger Trott (Lond: University of London)H-Index: 11
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Dose to bone marrow using IMRT techniques in prostate cancer patients Purpose: To investigate the dose distribution in active bone marrow of patients undergoing intensity-modulated radiotherapy (IMRT) for prostate cancer and compare it to the distribution in the same patients, if they had been treated using conformal plans, in order to develop criteria for optimization to minimize the estimated risk of secondary Leukemia. Patients and Methods: Mean bone marrow doses were calculated for ten patie...
30 CitationsSource
Background: Many young adults with cancer of good prognosis seek advice from their doctors, because they are concerned about their ability to have children and about potential hereditary diseases in the children conceivedor fathered after cancer therapy. Patients and Methods: Results of repeated examinations of 61 children over a period of 20 years are reported. One of their parents had received radiotherapy for malignant disease (only three had additional chemotherapy). Radiation doses to the g...
#1Thomas HerrmannH-Index: 21
#2Grit ThiedeH-Index: 1
Last. Lutz VoigtmannH-Index: 6
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BACKGROUND: Many young adults with cancer of good prognosis seek advice from their doctors, because they are concerned about their ability to have children and about potential hereditary diseases in the children conceived or fathered after cancer therapy. PATIENTS AND METHODS: Results of repeated examinations of 61 children over a period of 20 years are reported. One of their parents had received radiotherapy for malignant disease (only three had additional chemotherapy). Radiation doses to the ...
9 CitationsSource
Die gute Prognose einiger Tumorerkrankungen im jungen Erwachsenenalter fordert haufig die Beratung der Patienten mit Kinderwunsch nach Therapieende hinsichtlich der genetischen Konsequenzen der Strahlenbehandlung. Es wird uber die Ergebnisse der uber einen Zeitraum von 20 Jahren wiederholten Untersuchungen von 61 Kindern berichtet, von denen sich ein Elternteil wegen einer Tumorerkrankung einer alleinigen Strahlentherapie (nur in drei Fallen mit zusatzlicher Chemotherapie) unterziehen musste. Da...
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#1Klaus-Rüdiger Trott (QMUL: Queen Mary University of London)H-Index: 11
3 CitationsSource
#1Eduard Gershkevitsh (UT: University of Tartu)H-Index: 1
#2Guido Hildebrandt (Leipzig University)H-Index: 40
Last. Klaus-Rüdiger Trott (QMUL: Queen Mary University of London)H-Index: 11
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Radiotherapy plays an important role in the management of prostate cancer. Epidemiological data indicate a small but sinificant risk of radiation-induced leukemia after radiotherapy which might be related to the high mean bone marrow dose associated with radiotherapy of prostate cancer. The purpose of the study was to investigate the relation between the mean bone marrow dose and unstable chromosome aberrations in peripheral blood lymphocytes in patients undergoing conformal radiotherapy for pro...
12 CitationsSource
#1Johann KummermehrH-Index: 10
#2Eirik MalinenH-Index: 22
Last. Klaus-Rüdiger Trott (QMUL: Queen Mary University of London)H-Index: 11
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Abstract Purpose: To study the influence of tumor fibroblasts on radiosensitivity and stem cell fraction of tumor cells in squamous cell carcinoma megacolonies by determining colony cure and clonogen survival. Methods and Materials: Murine squamous cell carcinoma cells (AT478c) grown as flat but multilayered megacolonies were co-cultured with pre-irradiated tumor fibroblasts derived from the same carcinoma, and irradiated with 1, 2, 4, or 8 fractions. Recurrent clones and their growth pattern in...
7 CitationsSource
#1Klaus-Rüdiger Trott (QMUL: Queen Mary University of London)H-Index: 11
#2Michael Baumann (TUD: Dresden University of Technology)H-Index: 67
Eine Reihe experimenteller Untersuchungen und randomisierter klinischer Studien zeigen eine Abnahme der lokalen Tumorkontrolle mit zunehmender Gesamtbehandlungszeit einer fraktionierten Strahlentherapie. Die wahrscheinlichste Ursache dises Zeitfaktors ist die Proliferation klonogener Tumorzellen wahrend der Therapie. Durch eine gezielte Hemmung der Proliferation klonogener Zellen wahrend einer Strahlenbehandlung konnten daher moglicherweise wesentliche Fortschritte in der Radioonkologie erreicht...
7 CitationsSource