Michael Baumann
Helmholtz-Zentrum Dresden-Rossendorf
IrradiationCancerInternal medicinePathologyOncologyCellDose fractionationChemistryMedical physicsIn vivoCarcinomaHypoxia (medical)Epidermal growth factor receptorNuclear medicineCancer researchRadiation therapyCancer stem cellRadioresistanceMedicineBiology
Publications 276
#1Jacqueline Nathansen (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 2
#2Vasyl Lukiyanchuk (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 2
Last. Anna Dubrovska (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 33
view all 11 authors...
Head and neck squamous cell carcinoma (HNSCC) is often being diagnosed at an advanced stage, conferring a poor prognosis. The probability of local tumor control after radiotherapy depends on the eradication of cancer stem cells (CSCs) with activated DNA repair. This study provides evidence that the CSC-related transcription factor Oct4 contributes to HNSCC radioresistance by regulating DNA damage response and the CSC phenotype. Knockdown of Oct4 A isoform reduced self-renewal capacity in HNSCC a...
#1Thomas RachelH-Index: 1
#2Michael BaumannH-Index: 68
Last. Katrin BenninghoffH-Index: 1
view all 8 authors...
#1Ricardo OtazoH-Index: 27
#2Philippe LambinH-Index: 114
Last. Hedvig HricakH-Index: 137
view all 7 authors...
Radiation therapy (RT) continues to be one of the mainstays of cancer treatment. Considerable efforts have been recently devoted to integrating MRI into clinical RT planning and monitoring. This integration, known as MRI-guided RT, has been motivated by the superior soft-tissue contrast, organ motion visualization, and ability to monitor tumor and tissue physiologic changes provided by MRI compared with CT. Offline MRI is already used for treatment planning at many institutions. Furthermore, MRI...
#1Anna Mukha (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 2
#2Ugur Kahya (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 2
Last. Vladyslav Telychko (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 1
view all 38 authors...
Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells. However, PCa radiocurability can be impeded by tumor resistance mechanisms and normal tissue toxicity. Metabolic reprogramming is one of the major hallmarks of tumor progression and therapy resistance. Specific metabolic features of PCa might serve as therapeutic targets for tumor radio...
#1Sarah Meneceur (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 2
#2Annett Linge (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 20
Last. Cläre von Neubeck (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 13
view all 12 authors...
Glioblastoma is an aggressive brain tumour with a patient median survival of approximately 14 months. The development of innovative treatment strategies to increase the life span and quality of life of patients is hence essential. This requires the use of appropriate glioblastoma models for preclinical testing, which faithfully reflect human cancers. The aim of this study was to establish glioblastoma patient-derived xenografts (PDXs) by heterotopic transplantation of tumour pieces in the axilla...
#1Karolin Schneider (DKFZ: German Cancer Research Center)H-Index: 1
#2Nadja Ebert (DKFZ: German Cancer Research Center)H-Index: 2
Last. Michael Baumann (DKFZ: German Cancer Research Center)H-Index: 68
view all 4 authors...
Over the past several years, significant technological and biological progress has been made in radiation oncology with focus on the development of new treatment schemes to target tumors more precisely and increase the susceptibility of tumor cells to radiation therapy. It is essential that new treatment concepts are first appropriately evaluated and validated in preclinical settings before they are translated into the clinic. In vivo models are the most valid model systems for preclinical inves...
#1Philippe LambinH-Index: 114
Last. Nadja EbertH-Index: 2
view all 4 authors...
#1David Digomann (HZDR: Helmholtz-Zentrum Dresden-Rossendorf)H-Index: 2
#2Ina Kurth (DKFZ: German Cancer Research Center)H-Index: 8
Last. Anna Dubrovska (TUD: Dresden University of Technology)H-Index: 33
view all 25 authors...
Purpose: The heavy chain of the CD98 protein (CD98hc) is encoded by the SLC3A2 gene. Together with the light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. HighSLC3A2 mRNA expression levels are associated with poor prognosis in patients with head and neck squamous cell carcinoma (HNSCC) treated with radiochemotherapy. Little is known regarding the CD98hc protein-mediated molecular mechanisms of tumor radioresistance. Experimental Design: CD98hc protein exp...
#1Ruijuan Li (SDU: Shandong University)H-Index: 5
#2L. Helbig (TUD: Dresden University of Technology)H-Index: 4
Last. Youming Zhang (SDU: Shandong University)H-Index: 27
view all 11 authors...
Abstract Abnormal blood vessels and hypoxic and necrotic regions are common features of solid tumors and related to the malignant phenotype and therapy resistance. Certain obligate or facultative anaerobic bacteria exhibit inherent ability to colonize and proliferate within solid tumors in vivo. Escherichia coli Nissle 1917 (EcN), a non-pathogenic probiotic in European markets, has been known to proliferate selectively in the interface between the viable and necrotic regions of solid tumors. The...
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