• A review of the charts of 112 patients (141 eyes) presenting with a metastasis to the eye or orbit revealed that breast cancer was the most common primary tumor (49.1%). The median survival time (MST) following choroidal metastasis for all stages of breast cancer was 314 days. The MST after choroidal metastasis in patients thought to have stage I or II breast cancer, prior to diagnosis of the metastasis, was longer than that of patients with stage III or IV cancer (873 vs 139 days, respectively). Lung cancer metastasized to the eye and orbit earlier than did breast cancer (276 vs 1266 days, respectively) and had a shorter MST following this metastasis (188 vs 666 days, respectively). When age was considered as a continuous variable, the data indicated that older patients with breast metastases survived longer than did younger patients. Echography demonstrated that choroidal metastases from breast tumors were thicker than those from lung tumors (3.70 vs 2.59 mm, respectively).
To determine the frequency of ocular metastases in the general population, we conducted a prospective histopathologic study of 716 eyes obtained from patients who had malignant neoplasms at the time of death. Fifty-two patients had ocular metastases; all of these individuals had widespread metastases that contributed to their deaths. The overall incidence of ocular metastases among all fatal cases of cancer was 9.3%. Thirty-three of the 117 patients with various types of leukemia and four of the...
#1Linda Mewis(University of Texas Health Science Center at Houston)H-Index: 2
#2Sue E. Young(University of Texas Health Science Center at Houston)H-Index: 1
Abstract Two hundred fifty patients with breast carcinoma had ocular examinations between 1973 and 1980. One hundred fifty-two patients were referred because of ocular symptoms or signs, and 98 were asymptomatic. Of the symptomatic patients, 58 had choroidal metastases; nine of the asymptomatic patients with stage IV metastatic breast cancer had choroidal involvement (9.2%). For the 67 patients with metastases, the median age at ocular diagnosis was 51 years. The median interval from primary to ...
Praise for the Third Edition. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject. Statistics in Medical ResearchUpdated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified author team, the Fourth Edition is a critically accl...
Although metastatic cancer to the uvea is reported to be the most common intraocular malignancy, most ophthalmologists have had little experience with its diagnosis and treatment. This report describes our experience with the diagnosis and management of 70 patients with metastatic cancer to the uvea. Many patients were evaluated with modern diagnostic modalities such as fluorescein angiography, ultrasonography, and the 32 P test when indicated. Thirty-one percent of patients had no history of pr...
#1Ramon L. Font(CUNY: City University of New York)H-Index: 1
#2Andrew P. Ferry(CUNY: City University of New York)H-Index: 8
Two hundred and twenty-seven cases of carcinoma metastatic to the eye and orbit have been reviewed previously. The orbit alone was involved in 28 cases; these lesions constitute the basis of this clinicopathologic study. The most common signs and symptoms produced by orbital metastasis included exophthalmos (75%), pain (29%), decreased vision (29%), periorbital swelling (25%), a visible mass (21%), ophthalmoplegia, and diplopia (18%). The ophthalmologists' preoperative (or premortem) clinical di...
Of 227 cases of carcinoma metastatic to the eye or orbit, the predominant involvement was in the eye in 196 cases, the orbit in 28, and in the optic nerve in 3 cases. There was no preponderance of left-sided involvement. The primary sites accounting for the most cases were the breast (40%) and the lung (29%). Of the 217 patients regarding whom follow-up information was obtainable, 192 were known to have died of metastatic tumor. The median survival was 7.4 months from the time of ocular/orbital ...
Eyes from 230 patients with autopsy-proven carcinomas originating from various primary sites were subjected to postmortem examination. In 28 cases (12%), metastatic foci were demonstrated histologically. Over one third of the 52 patients with breast carcinoma were found to have ocular metastases. These are higher incidences than have been previously reported in clinical studies. The significance of the high incidence of ocular metastatic carcinoma is discussed.
Despite their unassuming size, lacrimal glands can have a variety of pathologies affecting them which often poses a diagnostic challenge clinically in view of their nonspecific presentation as palpable lump in the superolateral aspect of the orbit. There are a myriad of pathological entities ranging from inflammatory to neoplastic lesions that can affect the lacrimal glands. Cross-sectional imaging is must for the detection, characterization, and mapping of these lesions. In this pictorial revie...
Abstract null null Purpose null To report a case of ciliary body metastasis with uncontrolled glaucoma that was successfully treated with micropulse transscleral laser therapy (MPTLT). null null null Observations null A case of a 44-year-old female with uncontrolled glaucoma secondary to ciliary body metastasis from pulmonary adenocarcinoma. Antiglaucoma medications, intravitreal ranibizumab injection and local radiotherapy were ineffective in reducing her intraocular pressure (IOP) and ocular p...
INTRODUCTION AND PURPOSE Choroidal metastases (CM) are the most common intraocular malignancies. With longer survival rates for cancer patients, CM will be increasingly encountered. We evaluated clinical and ultrasonographic (US) characteristics of CM in order to identify diagnostic biomarkers that correlate with the primary tumor site. METHODS The medical records of all patients with CM evaluated at the Ocular Oncology Unit between February 2010 and March 2020 were analyzed. RESULTS 82 eyes of ...
BACKGROUND Metastatic disease to the eye most commonly involves choroid followed by orbit leading to varied ocular manifestations. By comparison, it is relatively rarer than primary malignancies of eye as well as metastasis in other parts of the body. AIM The aim of this study is to evaluate the common eye and orbital structures involved in secondary ocular and metastatic disease, to describe its clinical manifestations and outline the management done. METHODS A retrospective study of newly diag...
Purpose The eye and its adnexal structures can give rise to first or consecutive primary malignancies or to encounter metastasis. Our aim was to define the characteristics of the second primary neoplasms affecting the eye and its adnexa and find the risk modifying factors for them after malignancies elsewhere in the body. Methods We have queried the Surveillance, Epidemiology and End-Results "SEER"-9 program of the National Cancer Institute for the malignancies of the eye and its adnexa that occ...
A 62-year-old woman was referred for evaluation of a nonhealing epithelial defect of the left eye. Examination also revealed left upper lid ptosis, cicatricial lagophthalmos, and palpable lid masses. With probing, the patient admitted to recent history of lobular carcinoma and remote history of ductal carcinoma of the breast. Imaging showed abnormal tissue in the left extraconal orbit involving the lacrimal gland. After orbitotomy and biopsy of the mass, pathology specimens returned consistent w...
Ocular metastatic lesions from head to neck region are rare. 55 years old male patient presented with loss of vision, pain, and proptosis of the left eye. The patient was known case of laryngeal squamous carcinoma underwent laryngectomy 1 and half years back followed by chemoradiation. Well-defined scleral nodule extending from limbus to optic nerve was noted. In view of no other metastatic focus other than left eye on positron emission tomography (PET) scan, left eye enucleation was performed. ...