Flavan-3-ols from the roots of Actinidia arguta inhibit the formation of advanced glycation end products (AGEs) in vitro

In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines [1–3], two new flavan-3-ols, 8-(2-pyrrolidinone-5-yl)-(–)-epicatechin (1) and 6-(2-pyrrolidinone-5-yl)-(–)-epicatechin (2), as well as five known compounds, (–)-epicatechin (3), (+)-catechin (4), proanthocyanidin B-4 (5), (+)-pinoresinol (6), and p-hydroxybenzoic acid (7), were isolated from an EtOAc-soluble...