Ga Young Lee
Ministry of Food and Drug Safety
Biological activityH&E stainPathologyGlycationCellMolecular biologyPharmacognosyInhibitory postsynaptic potentialChemistryIn vitroActinidia argutaLactamUlmus davidianaAdvanced glycation end-productFlavanCornus officinalisActinidiaBetulinic acidDraize testCorosolic acidCorneal epitheliumUrsolic acidLipaseEzrinTriterpeneUlmus davidiana var. japonicaFlavan-3-olHydrolyzable TanninData interpretationIc50 valuesTerpeneColumn chromatographyEpitheliumBiochemistryStereochemistryMedicineStainingProanthocyanidinBiologyBovine serum albumin
7Publications
3H-index
132Citations
Publications 6
Newest
#1Kyung Yuk Ko (Ministry of Food and Drug Safety)H-Index: 4
#2Mi Hye Hong (Ministry of Food and Drug Safety)H-Index: 1
Last. Jong Kwon Lee (Ministry of Food and Drug Safety)H-Index: 2
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Abstract Introduction A variety of in vitro tests to replace the Draize test have been developed; however, there is no available method for assessing the full spectrum of Globally Harmonized System (GHS) categories. Human cornea-like three-dimensional (3D) reconstructed tissue models are the most promising in vitro systems. The objective of this study was to evaluate the ocular toxicity of 11 test substances using the EpiOcular™ model after performing proficiency tests. We further evaluated the ...
2 CitationsSource
#1Dae Sik JangH-Index: 31
#2Ga Young LeeH-Index: 3
Last. Jin Sook KimH-Index: 35
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Two new flavan-3-ols, 6-(2-pyrrolidinone-5-yl)-(-)-epicatechin (1) and 8-(2-pyrrolidinone-5-yl)-(-)-epicatechin (2), as well as five known compounds, (-)-epicatechin (3), (+)-catechin (4), proanthocyanidin B-4 (5), (+)-pinoresinol, and p-hydroxybenzoic acid, were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation, particularly by extensive 1D- and 2D-NMR studies. All the isolates were e...
68 CitationsSource
#1Ga Young LeeH-Index: 3
#2Dae Sik JangH-Index: 31
Last. Jin Sook KimH-Index: 35
view all 7 authors...
Four flavan-3-ols, (+)-catechin ( 1), (+)-catechin 7- O- β- D-apiofuranoside ( 2), (+)-catechin 7- O- β- D-xylopyranoside ( 3), (+)-catechin 7- O- β- D-glucopyranoside ( 4), and proanthocyanidin A-1 ( 5) as well as three other constituents, isolated from an EtOAc-soluble extract of the stem barks of ULMUS DAVIDIANA var. JAPONICA, were evaluated for inhibitory activity against the formation of AGEs. Compounds 1 - 5 exhibited a significant inhibitory activity on the formation of AGEs in an AGEs-BS...
18 CitationsSource
#1Ga Young LeeH-Index: 3
#2Dae Sik JangH-Index: 31
Last. Ju Sun KimH-Index: 28
view all 6 authors...
Source
#1Ga Young LeeH-Index: 3
#2Dae Sik JangH-Index: 31
Last. Ju Sun KimH-Index: 28
view all 6 authors...
Source
#1Dae Sik JangH-Index: 31
#2Ga Young LeeH-Index: 3
Last. Jin Sook KimH-Index: 35
view all 7 authors...
A new coumaroyl triterpene, 3-O-trans-p-coumaroyl actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1–6) were evaluated in vitro for their inhibitory acti...
86 CitationsSource