Ju Sun Kim
Seoul National University
TriterpenoidInternal medicineEndocrinologyPharmacognosyOrganic chemistryChemistryGlycosideIn vivoAntioxidantSaponinAraliaceaeDaucosterolTriterpeneGlucosidePharmacology toxicologyTerpeneBiochemistryTraditional medicineBotanyStereochemistryMedicineBiologyPharmacology
Publications 91
#1Min Hye YeanH-Index: 4
#2Ju Sun KimH-Index: 28
Last. Yeong Shik KimH-Index: 79
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A new megastigmane glucoside, simplicifloranoside (1), and three new flavonol glycosides, prunifolianosides A–C (2–4, resp.), were isolated from the aerial parts of Spiraea prunifolia var. simpliciflora. In addition, fifteen known compounds, including five phenolic acids, three lignans, four flavonoids, one eugenol glycoside, and two alkyl-primeverosides, were also identified. Their structures were elucidated on the basis of detailed spectroscopic analyses and acid hydrolysis.
6 CitationsSource
#1In Ho Jung (Kyung Hee University)H-Index: 6
#2Hyung Eun Lee (Kyung Hee University)H-Index: 16
Last. Jong Hoon Ryu (Kyung Hee University)H-Index: 51
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Abstract Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa . This study investigated the effect of spinosin on cholinergic blockade-induced memory impairment in mice. Behavioral tests were conducted using the passive avoidance, Y-maze, and Morris water maze tasks to evaluate the memory-ameliorating effect of spinosin. Spinosin (10 or 20 mg/kg, p.o.) significantly ameliorated scopolamine-induced cognitive impairment in these behavioral tasks with a prolon...
44 CitationsSource
#1Yuna Pyee (SNU: Seoul National University)H-Index: 7
#2Hwa-Jin ChungH-Index: 23
Last. Sang Kook LeeH-Index: 59
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The anti-inflammatory activity of handelin (1), a guaianolide dimer from Chrysanthemum boreale flowers, was evaluated in vivo, and the effects on mediators nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) and the nuclear factor-κB (NF-κB) and ERK/JNK signaling pathways were investigated in vitro. Compound 1 inhibited lipopolysaccharide (LPS)-induced production of NO and PGE2 in cultured mouse macrophage RAW 264.7 cells. The suppression of NO...
12 CitationsSource
#1Joo-Young Lee (SNU: Seoul National University)H-Index: 25
#2Ju Sun Kim (SNU: Seoul National University)H-Index: 28
Last. Sam Sik Kang (SNU: Seoul National University)H-Index: 70
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: An investigation of the Korean medicinal plant Patrinia villosa (THUNB.) JUSS. (Valerianaceae) led to the isolation of two new flavonoid glycosides, patrivilosides 1 (1) and 2 (2), a new iridoid glycoside, patrinovalerosidate (3), and two new saponins, patrinovilosides A (4) and B (5), along with six known compounds including three flavonoid glycosides and three iridoid glycosides. The structures of the new compounds were elucidated based on analysis of their one dimensional (1D)- and 2D-NMR s...
9 CitationsSource
#1Hyung Eun Lee (Kyung Hee University)H-Index: 16
#2So Young LeeH-Index: 2
Last. Jong Hoon Ryu (Kyung Hee University)H-Index: 51
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In the present study, we investigated the effect of ethanolic extract of the seed of Zizyphus jujuba var. spinosa (EEZS) on cholinergic blockade-induced memory impairment in mice. Male ICR mice were treated with EEZS. The behavioral tests were conducted using the passive avoidance, the Y-maze, and the Morris water maze tasks. EEZS (100 or 200 mg/kg, p.o.) signifi cantly ameliorated the scopolamine-induced cognitive impairment in our present behavioral tasks without changes of locomotor activity....
28 CitationsSource
#1So Young LeeH-Index: 2
#2Ju Sun KimH-Index: 28
Last. Sam Sik Kang (SNU: Seoul National University)H-Index: 70
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Sour jujube (Zizyphus jujuba Miller var. spinosa Hu ex H. F. Chou) is a thorny, rhamnaceous deciduous plant distributed widely throughout tropical and subtropical regions. The dried seeds are named sanjoin (Zizyphi Spinosi Semen) in Korean and have a thousand-year history of use in traditional medicine as a sedative for treating mild anxiety, nervousness and sleep-related problems. Previous phytochemical investigations on the seeds of this plant have resulted in the isolation of saponins, flavon...
4 CitationsSource
#1J. KimH-Index: 3
Last. Ju Sun KimH-Index: 28
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#1Yunkyung Han (Dongguk University)H-Index: 8
#2Hyo Won JungH-Index: 20
Last. Yong-Ki ParkH-Index: 6
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Abstract Rehmanniae Radix Preparata, the steamed root of Rehmannia glutinosa Libosch, has been widely used for the treatment of inflammatory conditions in Oriental medicines. In this study we evaluated the effects of 2,5-dihydroxyacetophenone (DHAP) isolated from Rehmanniae Radix Preparata on inflammatory responses in lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophages. LPS-stimulated RAW264.7 cells were used to investigate the anti-inflammatory activity of DHAP on the production of i...
24 CitationsSource
#1Hyunjung Shin (SNU: Seoul National University)H-Index: 49
#2Lee So Young (SNU: Seoul National University)
Last. Sam Sik Kang (SNU: Seoul National University)H-Index: 70
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Six new germacranolides, zawadskinolides A—F (1—6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. latilobum, along with thirteen known constituents. Their structures were elucidated by means of spectroscopic evidence. Bioassay showed that flavonoids such as apigenin (9), (−)-eriodictyol (10) and nepetin (12), as well as the sesquiterpene lactone, zawadskinolide F (6), inhibited nitric oxide (NO) production in lipopolysacch...
7 CitationsSource