Dae Sik Jang
Kyung Hee University
CytotoxicityInternal medicineEndocrinologyGlycationMolecular biologyInhibitory postsynaptic potentialTumor necrosis factor alphaKinaseChemistryApoptosisIn vitroAldose reductaseLipopolysaccharideMorris water navigation taskNitric oxideBiochemistryTraditional medicineStereochemistryMedicineBiologyPharmacology
Publications 163
#1Jaeyoung Kwon (KIST: Korea Institute of Science and Technology)H-Index: 13
#2Hoseong Hwang (KIST: Korea Institute of Science and Technology)H-Index: 1
Last. Jae Wook Lee (KIST: Korea Institute of Science and Technology)H-Index: 13
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Abstract null null The consumption of sprouts has been steadily increasing due to their being an excellent source of nutrition. It is known that the bioactive constituents of legumes can be increased after germination. In this study, the extract from Senna tora sprouts is shown to exhibit improved radical scavenging activities and better neuroprotective effects in HT22 hippocampal neuronal (HT22) and R28 retina precursor (R28) cells than those from seeds due to an increased content of phenolic c...
#1Jeong-Hwa Woo (Kyung Hee University)H-Index: 7
#2Dae Sik Jang (Kyung Hee University)H-Index: 31
Last. Jung-Hye Choi (Kyung Hee University)H-Index: 32
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Luteolin, a flavonoid present in several fruits, vegetables, nuts, and herbs reportedly exhibits anti-cancer and anti-inflammatory properties. However, the effect of luteolin on endometriosis, a painful condition characterized by the ectopic growth of endometrial tissue and pelvic inflammation, remains elusive. Herein, we observed that luteolin inhibited cell growth and induced apoptosis of 12Z human endometriotic cells by activating caspase-3, -8, and -9. Additionally, luteolin significantly in...
#1Kun Won LeeH-Index: 8
#2Ahmed H.E. HassanH-Index: 11
Last. Yu-jeong LeeH-Index: 1
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The chiral molecule, methoxetamine (MXE), demonstrated promising biological effects in management of treatment-resistant depression patients. To satisfy the need for a method capable of providing gram quantities of each enantiopure stereoisomer of MXE to enable advanced biological studies of enantiomers, a protocol was developed to access gram scale quantities of (R)- and (S)-MXE in the form of pharmaceutically acceptable HCl salts employing L-(−)-DTTA and D-(+)-DTTA ((−)-O,O′-di-p-toluoyl-L-tar...
#1Suk Woo Chang (Kyung Hee University)H-Index: 2
#2Jin Su Lee (Kyung Hee University)H-Index: 7
Last. Dae Sik Jang (Kyung Hee University)H-Index: 31
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Cinnamomum cassia Presl (Cinnamon) has been widely cultivated in the tropical or subtropical areas, such as Yunnan, Fujian, Guandong, and Hainan in China, as well as India, Vietnam, Thailand, and Malaysia. Four new glycosides bearing apiuronic acid (1, 4, 6, and 7) and their sodium or potassium salts (2, 3, and 5), together with 31 known compounds, were isolated from a hot water extract of the bark of C. cassia via repeated chromatography. The structures of the new compounds (1-7) were determine...
#1Dahae Lee (Gachon University)H-Index: 17
#2Yutong Qi (Kyung Hee University)H-Index: 1
Last. Ki Sung Kang (Gachon University)H-Index: 24
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Phenolic compounds from natural products are considered effective enhancers of insulin secretion to prevent and treat type 2 diabetes (T2DM). The flowers of Prunus persica (L.) Batsch also contain many phenolic compounds. In this study, the extract of flowers of P. persica (PRPE) exhibited an insulin secretion effect in a glucose-stimulated insulin secretion (GSIS) assay, which led us to isolate and identify the bioactive compound(s) responsible for these effects. Compounds isolated from PRPE we...
#1Jiyoung Kim (Kyung Hee University)H-Index: 26
#2Young Hye SeoH-Index: 5
Last. Dae Sik Jang (Kyung Hee University)H-Index: 31
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Four new eudesmane-type sesquiterpenoids, (1R,5S,6R,7S,9S,10S)-1,6,9-trihydroxy-eudesm-3-ene-1,6-di-O-β-d-glucopyranoside (1), (1R,5S,6S,7R,9S,10S)-1,6,9,11-tetrahydroxy-eudesm-3-ene-1,6-di-O-β-d-glucopyranoside (3), (1R,5S,6R,7S,9S,10R)-9-O-(Z-p-coumaroyl)-1,6,9-trihydroxy-eudesm-3-ene-6-O-β-d-glucopyranoside (6), and (1R,5S,6R,7S,9S,10R)-9-O-(E-feruloyl)-1,6,9-trihydroxy-eudesm-3-ene-6-O-β-d-glucopyranoside (7), were isolated from a 95% EtOH extract of the leaves of Aster koraiensis by repeate...
#1Sunghee Bang (Duksung Women's University)H-Index: 7
#2Ha Eun Kwon (KU: Korea University)
Last. Sang Hee Shim (Duksung Women's University)H-Index: 20
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Abstract Three unusual polyketides with a 5/6/10-fused ring system, named colletotrichalactones A-Ca (1-3a), were isolated from cultures of the endophytic fungus, Colletotrichum sp. JS-0361, which was isolated from a leaf of Morus alba. Their structures, including their absolute stereochemistries, were completely established using extensive spectroscopic methods together with a chemical reaction utilizing competing enantioselective acylation coupled with LC/MS. Compounds possessing this ring ske...
#1Young Hye SeoH-Index: 5
#2Tuy An Trinh (Gachon University)H-Index: 5
Last. Jun LeeH-Index: 11
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A new phenolic glucoside, (7E,9E)-3-hydroxyavenalumic acid-3-O-[6'-O-(E)-caffeoyl]-β-d-glucopyranoside (1), and three new acetylated flavone glycosides, acacetin-7-O-[β-d-glucopyranosyl(1″″→2″)-4‴-O-acetyl-α-l-rhamnopyranosyl(1‴→6″)]-β-d-glucopyranoside (3), acacetin-7-O-[6″″-O-acetyl-β-d-glucopyranosyl(1″″→2″)-3‴-O-acetyl-α-l-rhamnopyranosyl(1‴→6″)]-β-d-glucopyranoside (5), and acacetin-7-O-[3″″,6″″-di-O-acetyl-β-d-glucopyranosyl(1″″→2″)-4‴-O-acetyl-α-l-rhamnopyranosyl(1‴→6″)]-β-d-glucopyranosi...
#1Yutong Qi (Kyung Hee University)H-Index: 1
Last. Dae Sik JangH-Index: 31
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Campanula takesimana Nakai (Campanulaceae; Korean bellflower) is one of the endemic herbs of Korea. The plant has been used as traditional medicines for treating asthma, tonsillitis, and sore throat in Korea. A hot water extract of the leaves of C. takesimana exhibited a significant inhibitory effect on lipopolysaccharide (LPS)-stimulated prostaglandin E2 (PGE2) production. Repetitive chromatographic separation of the hot water extract led to the isolation of three new neolignan glucosides, camp...
#1Hwi-Ho Lee (Kyung Hee University)H-Index: 10
#2Eungyeong Jang (Kyung Hee University)H-Index: 7
Last. Kyung-Tae Lee (Kyung Hee University)H-Index: 69
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Abstract Patrineolignan B (PB), a lignan compound isolated from the radix and rhizomes of Patrinia scabra, was previously reported to possess a strong tumor-specific cytotoxic activity and beneficial effects on nitric oxide (NO) levels in macrophages induced by lipopolysaccharide (LPS). In this study, we assessed the effects of PB on LPS-induced inflammation in RAW 264.7 cells and clarified its molecular mechanisms. PB reversed LPS-induced increase in NO levels and prostaglandin E2 (PGE2) produc...
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