Interaction of pituitary hormones and expression of clock genes modulated by bone morphogenetic protein-4 and melatonin

Volume: 459, Issue: 1, Pages: 172 - 177
Published: Mar 1, 2015
Abstract
Functional interaction of clock genes and pituitary hormones was investigated by focusing on bone morphogenetic protein (BMP)-4 and melatonin actions in anterior pituitary cells. A significant correlation between the mRNA expression of proopiomelanocortin (POMC) and Per2 was revealed in serial cultures of corticotrope AtT20 cells. Knockdown of Per2 expression by siRNA in AtT20 cells resulted in a significant reduction of POMC mRNA level with or...
Paper Details
Title
Interaction of pituitary hormones and expression of clock genes modulated by bone morphogenetic protein-4 and melatonin
Published Date
Mar 1, 2015
Volume
459
Issue
1
Pages
172 - 177
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