Biochemical and Biophysical Research Communications
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#1Mamoru Tanaka (Nagoya City University)H-Index: 14
#2Makiko Sasaki (Nagoya City University)
Last. Hiromi Kataoka (Nagoya City University)H-Index: 28
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Abstract Photodynamic therapy (PDT) utilizes photochemical reactions induced by a photosensitizer and light in the target tissue and is used to treat various cancers. There is a high degree of anticipation of success regarding the application of PDT with talaporfin (photosensitizer) for gastric cancer. Olaparib is an oral inhibitor of Poly (ADP-Ribose) polymerase (PARP) and has demonstrated optimal efficacy and clinical activity in trials. Therefore, the aim of the present study was to investiga...
#1Shoko Matsuoka (TUAT: Tokyo University of Agriculture and Technology)
#2Karin Sato (TUAT: Tokyo University of Agriculture and Technology)
Last. Taishi Umezawa (TUAT: Tokyo University of Agriculture and Technology)H-Index: 27
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Abstract Abscisic acid (ABA) is a major phytohormone that regulates abiotic stress responses and development. SNF1-rerated protein kinase 2 (SnRK2) is a key regulator of ABA signaling. To isolate compounds which directly affect SnRK2 activity, we optimized a fluorescence-based system for high-throughput screening (HTS) of SnRK2 kinase regulators. Using this system, we screened a chemical library consisting of 16,000 compounds and identified ten compounds (INH1-10) as potential SnRK2 inhibitors. ...
#1Lin Zhao (Xi'an Jiaotong University)H-Index: 2
#2Jiali SuH-Index: 1
Last. Rui-zhe Huang (Xi'an Jiaotong University)H-Index: 1
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Abstract Dental fluorosis is characterized by hypomineralization of tooth enamel caused by ingestion of excessive fluoride during enamel formation. Excess fluoride could have effects on the ERK signaling, which is essential for the ameloblasts differentiation and tooth development. MAP kinase phosphatase-1 (MKP-1) plays a critical role in regulating ERK related kinases. However, the role of MKP-1 in ameloblast and the mechanisms of MKP-1/ERK signaling in the pathogenesis of dental fluorosis are ...
#1Yusuke TakahashiH-Index: 13
#2Satoshi Serada (Kōchi University)H-Index: 29
Last. Tetsuji Naka (Kōchi University)H-Index: 52
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Abstract Lipolysis-stimulated lipoprotein receptor (LSR), also known as a component of tricellular tight junctions, is highly expressing in epithelial ovarian cancer (EOC). However, the biological role of LSR in EOC cells remains unclear. In this study, we evaluated liver kinase B1 (LKB1) mediated AMP-activated protein kinase (AMPK) activity and investigated the effect of LSR on EOC cell survival under energy stress. LSR increased the levels of phospho-AMPKα at Thr172 and phospho-acetyl-CoA carb...
#1Xueying Zhao (HMU: Harbin Medical University)H-Index: 1
#2Liyuan Zhang (HMU: Harbin Medical University)
Last. Yuwen Wang (HMU: Harbin Medical University)H-Index: 7
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Abstract Hydrogen sulfide (H2S) prevents platelet activation and neutrophils extracellular traps (NETs) formation. However, the mechanism of sodium hydrosulfide (NaHS, a donor that produces H2S) inhibits the formation of NETs in hyperhomocysteinemia (HHcy) rats has not been previously investigated. In the experiment, the expressions of HMGB1 of platelets, the expressions of TLR4, PAD4 and the phosphor-p38 of neutrophils were measured. The NETs formations, the concentration of DNA in the serum an...
1 CitationsSource
#1Hexiang Wang (SDU: Shandong University)
#2Lin Gao (SDU: Shandong University)H-Index: 2
Last. Bo Han (SDU: Shandong University)H-Index: 27
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Abstract Triple-negative breast cancer (TNBC) is a major challenge in clinical practice due to its aggressiveness and lack of targeted treatment. Cancer stem-like traits contribute to tumorigenesis and immune privilege of TNBC. However, the relationship of stemness and immunosurveillance remains unclear. Here, we demonstrate that BTF3 expression is related with stem-like properties in TNBC cells. BTF3 modulates stemness, migration and proliferation of TNBC in vitro. Bioinformatics analysis revea...
#1Xingyu Zhang (WHU: Wuhan University)H-Index: 2
#2Li Tang (WHU: Wuhan University)
Last. Zhentao Zhang (WHU: Wuhan University)H-Index: 21
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Abstract A disintegrin and metalloproteinases 10 (ADAM10) and ADAM17 are transmembrane metalloproteinases that cleave the membrane-anchored proteins. They act as α-secretase that cleaves amyloid precursor protein (APP), precluding the production of amyloid-β, thus protecting against the onset of Alzheimer’s disease (AD). However, the degradation pathway of ADAM10 and ADAM17 remains unknown. In this study, we show that ADAM10 and ADAM17 are degraded through the lysosomal pathway. The lysosomal cy...
#1Kunikazu Tanji (Hirosaki University)H-Index: 34
#2Fumiaki Mori (Hirosaki University)H-Index: 44
Last. Koichi Wakabayashi (Hirosaki University)H-Index: 63
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Abstract Transactive response DNA-binding protein of 43 kDa (TDP-43) abnormally forms aggregates in certain subtypes of frontotemporal lobar degeneration (FTLD) and in amyotrophic lateral sclerosis (ALS). The pathological forms of TDP-43 have reported to be associated with poly(ADP-ribose) (PAR), which regulates the properties of these aggregates. A recent study has indicated that tankyrase, a member of the PAR polymerase (PARP) family, regulates pathological TDP-43 formation under conditions of...
#1Zhenfeng ShiH-Index: 1
#2Jie ChenH-Index: 1
Last. Min Li (XMU: Xinjiang Medical University)H-Index: 1
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Abstract The prostate cancer (PCa) poses serious threat to men’s health. The androgen receptor (AR) is essential for normal prostate development and prostate cancer progression. We identified a novel lncRNA PCLN16 which is significantly correlated with AR signaling during prostate cancer progression. The AR-regulated PCLN16 was abundantly overexpressed in localized or metastatic prostate cancer tissues and AR-dependent cell lines. PCLN16 silence suppressed AR signaling and tumor growth. PCLN16 i...
1 CitationsSource
#1Qi-Fan Sun (ECUST: East China University of Science and Technology)
#2Yu-Cong Zheng (ECUST: East China University of Science and Technology)H-Index: 4
Last. Jiang Pan (ECUST: East China University of Science and Technology)H-Index: 22
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Abstract Oleate hydratase catalyzes the hydration of unsaturated fatty acids, giving access to C10-functionalization of oleic acid. The resultant 10-hydroxystearic acid is a key material for the synthesis of many biomass-derived value-added products. Herein, we report the engineering of an oleate hydratase from Paracoccus aminophilus (PaOH) with significantly improved catalytic efficiency (from 33 s−1 mM−1 to 119 s−1 mM−1), as well as 3.4 times increased half-life at 30 °C. The structural mechan...
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Molecular biology
Cell biology