Biochemical and Biophysical Research Communications
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Abstract null null The application of optogenetics in animals has provided new insights into both fundamental neuroscience and diseases of the nervous system. This is primarily due to the fact that optogenetics allows selectively activating or inhibiting particular types of neurons. One of the first transgenic mouse lines developed for the optogenetic experiment was Thy1-ChR2-YFP. Thy1 is an immunoglobulin superfamily member expressing in projection neurons, so it was assumed that channelrhodops...
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#1Rushi Lin (SHU: Shanghai University)
#2Haicong Zhou (SHU: Shanghai University)H-Index: 1
Last. Tieqiao Wen (SHU: Shanghai University)H-Index: 14
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Abstract null null Autism is one of the urgent problems in neuroscience. Early research in our laboratory found that dcf1 gene-deficient mice exhibited autistic behavior. Reviewing the literature, we know that the caudate putamen (CPu) brain region is closely related to the occurrence of autism. In this study, we observed that the electrical signal in the abnormal brain region of adult mice was enhanced by using field potential detection for the corresponding brain region. We then used retroviru...
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#1Yangchun Ma (Tianjin Medical University)
#2Ting-Ting Ding (Tianjin Medical University)H-Index: 1
Last. Run-Ling Wang (Tianjin Medical University)H-Index: 11
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Abstract null null Protein tyrosine phosphatase 1B (PTP1B) is a member of the phosphotyrosine phosphatase family and plays an important role in the signal transduction of diabetes. Inhibition of PTP1B activity can increase insulin sensitivity and reduce blood sugar levels. Therefore, it is urgent to find compounds with novel structures that can inhibit PTP1B. This study designed imidazolidine-2,4-dione derivatives through the computer-aided drug design (CADD) strategy, and the Comp#10 showed out...
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#1Zhengfei Guo (Henan University)
#2Xiaoyu Wang (Henan University)
Last. Zhenguo Shen (NAU: Nanjing Agricultural University)
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Abstract null null Pentatricopeptide repeat (PPR) proteins are a large family in land plants that play a role in organellular RNA processing, editing, and splicing. Here, we identify an Arabidopsis thaliana mutant, gend1-1, which exhibits a short root phenotype with reduced meristem size and cell numbers. Positional cloning of GEND1 revealed that it encodes a PPR protein, and functional analysis showed that GEND1 can bind and edit mitochondrial ccmFn-1 mRNA, causing gend1 mutants to have decreas...
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#1Rachel M. Johnson (Monash University)H-Index: 7
#2Xin Zhang (Monash University)H-Index: 4
Last. Denise Wootten (Monash University)H-Index: 33
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Abstract null null Dual agonists that can activate both the glucagon-like peptide-1 receptor (GLP-1R) and the gastric inhibitory polypeptide receptor (GIPR) have demonstrated high efficacy for the treatment of metabolic disease. Peptide-19 is a prototypical dual agonist that has high potency at both GLP-1R and GIPR but has a distinct signalling profile relative to the native peptides at the cognate receptors. In this study, we solved the structure of peptide-19 bound to the GLP-1R in complex wit...
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#1Anindita Das (SINP: Saha Institute of Nuclear Physics)H-Index: 3
#2Arpan Bysack (SINP: Saha Institute of Nuclear Physics)
Last. H. Raghuraman (SINP: Saha Institute of Nuclear Physics)H-Index: 3
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Abstract null null Membrane solubilization by detergents is a critical step for successful membrane protein purification. Alkyl maltoside detergents such as DDM and DM are very expensive and are commonly used to produce most of the high-quality proteins in stable and functional form. Recently, dual-detergent strategy using inexpensive detergents for membrane solubilization step has been shown to be highly effective in purifying different classes of membrane proteins in a cost-effective manner. I...
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#1Byong Seo Park (Incheon National University)H-Index: 4
#2Hye Li Im (UOU: University of Ulsan)
Last. Byung Ju Lee (UOU: University of Ulsan)H-Index: 23
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Abstract null null Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2. Consistent with these results, DRG2 Tg mice showed increased expression of genes involved in adipogenesis and lipid metabolis...
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Abstract null null Aim of the study null Acute lung injury (ALI) exhibits the features of noncardiogenic pulmonary edema and acute inflammatory process, and it also displays significant morbidity and mortality rates. This work focused on identifying how overexpression of PPARγ coactivator 1α (PGC-1α) positively regulated TFEB and mitophagy for resisting the lipopolysaccharide (LPS)-mediated ALI. null null null Materials and methods null The levels of autophagic proteins and inflammatory factors ...
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#1Juan Xie (HUST: Huazhong University of Science and Technology)H-Index: 3
#2Jinfang Zheng (HUST: Huazhong University of Science and Technology)H-Index: 5
Last. Shiyong Liu (HUST: Huazhong University of Science and Technology)H-Index: 18
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DNA-binding is an important feature of proteins, and protein-DNA interaction involves in many life processes. Various computational methods have been developed to predict protein-DNA complex structures due to the difficulty of experimentally obtaining protein-DNA complex structures. However, prediction of protein-DNA complex is still a challenging problem compared with prediction of protein-RNA complex, this may be due to the large conformational changes between bound and unbound structure in bo...
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#1Liping Zhang (CQMU: Chongqing Medical University)
#2Yilin Liu (CQMU: Chongqing Medical University)
Last. Gongwei Jia (CQMU: Chongqing Medical University)H-Index: 4
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Abstract null null Ischemic stroke is the leading cause of death and disability. Microglia are polarized toward the proinflammatory M1 phenotype and neuroprotective M2 phenotype after stroke and play an important role in the pathological process of ischemic stroke. Emerging research suggests that vagus nerve stimulation (VNS) can mediate microglia polarization after ischemic stroke and may serve as a potential treatment for ischemic stroke. However, the mechanism by which VNS mediates microglia ...
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