Transient Lower Esophageal Sphincter Relaxations and Reflux: Mechanistic Analysis Using Concurrent Fluoroscopy and High-Resolution Manometry

Background & AimsThe aim of this study was to perform a detailed analysis of the mechanics leading to esophagogastric junction (EGJ) opening during transient lower esophageal sphincter relaxations (tLESRs) using high-resolution manometry coupled with simultaneous fluoroscopy. Methods Six subjects without hiatus hernia had endoclips placed at the squamocolumnar junction and 10 cm proximal. A 36-channel solid-state manometric assembly was placed...