Last. Ah-Ra Jang(Chonnam National University)H-Index: 2
view all 18 authors...
Abstract null BACKGROUND & AIMS null WAP four-disulfide core domain protein 2 (WFDC2), also known as human epididymis protein 4 (HE4), is a small secretory protein that is highly expressed in fibrosis and human cancers, particularly in the ovaries, lungs, and stomach. However, the role of WFDC2 in carcinogenesis is not fully understood. The present study aimed to investigate the role of WFDC2 in gastric carcinogenesis using preneoplastic metaplasia models. null METHODS null Three spasmolytic pol...
Abstract null null Background & Aims null Tissue metaplasia is uncommon in adults because established cis-element programs resist rewiring. In Barrett’s esophagus, the distal esophageal mucosa acquires predominantly intestinal character, with notable gastric features, and is predisposed to develop invasive cancers. We sought to understand the chromatin underpinnings of Barrett’s metaplasia and why it commonly displays simultaneous gastric and intestinal properties. null null null Methods null We...
Improvements in disease management, as well as endoscopic technology and quality, have dramatically changed the way in which we conceptualize and manage inflammatory bowel disease–related dysplasia over the past 20 years. Based on evolving literature, we propose a conceptual model and best practice advice statements for the prevention, detection, and management of colorectal dysplasia in people with inflammatory bowel disease. This expert review was commissioned and approved by the American Gast...
#1Philipp K. Haber(ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 4
#2Marc Puigvehí(ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
Last. Myron Schwartz(ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 91
view all 11 authors...
Abstract null null Background and Aims null Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality with a rapidly changing landscape of treatments. In the past 20 years, numerous randomized controlled trials (RCT) have aimed at improving outcomes across disease stages. We aimed at analyzing the current evidence and identifying potential factors influencing response to therapies. null null null Methods null We conducted a systematic review of phase III RCTs across disease s...
Description null The purpose of this Clinical Practice Update Expert Review is to provide clinicians with guidance on the diagnosis and management of atrophic gastritis, a common preneoplastic condition of the stomach, with a primary focus on atrophic gastritis due to chronic Helicobacter pylori infection—the most common etiology—or due to autoimmunity. To date, clinical guidance for best practices related to the diagnosis and management of atrophic gastritis remains very limited in the United S...
Abstract null Background and Aims null Acute pancreatitis (AP) is an inflammatory disease with mild to severe course that is associated with local and systemic complications and significant mortality. Uncovering inflammatory pathways that lead to progression and recovery will inform ways to monitor and/or develop effective therapies. null Methods null We performed single-cell mass cytometry (CyTOF) analysis to identify pancreatic and systemic inflammatory signals during mild (referred as AP), se...
Last. Joanne X. Shen(KI: Karolinska Institutet)H-Index: 3
view all 23 authors...
Abstract null BACKGROUND AND AIMS null Oxidative stress plays a key role in the development of metabolic complications associated with obesity, including insulin resistance and the most common chronic liver disease worldwide, non-alcoholic fatty liver disease. We have recently discovered that the microRNA miR-144 regulates protein levels of the master mediator of the antioxidant response, NRF2. Upon miR-144 silencing, the expression of NRF2 target genes was significantly upregulated, suggesting ...