Peter J. Kahrilas
Northwestern University
AnatomyBolus (medicine)SwallowingInternal medicineSurgeryCardiologyPeristalsisGERDEsophagusHigh resolution manometryDiseaseAchalasiaEsophageal diseaseDysphagiaEsophageal motility disorderEsophagogastric junctionAnesthesiaRefluxMedicineGastroenterology
771Publications
122H-index
40.3kCitations
Publications 771
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#1Rena Yadlapati (UCSD: University of California, San Diego)H-Index: 18
#2Peter J. Kahrilas (NU: Northwestern University)H-Index: 122
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#1Dustin A. Carlson (NU: Northwestern University)H-Index: 23
#2Alexandra J. Baumann (NU: Northwestern University)H-Index: 5
Last. John E. Pandolfino (NU: Northwestern University)H-Index: 79
view all 9 authors...
INTRODUCTION High-resolution manometry (HRM) is generally considered the primary method to evaluate esophageal motility; functional luminal imaging probe (FLIP) panometry represents a novel method to do so and is completed during sedated endoscopy. This study aimed to compare HRM and FLIP panometry in predicting esophageal retention on timed barium esophagram (TBE). METHODS A total of 329 adult patients who completed FLIP, HRM, and TBE for primary esophageal motility evaluation were included. An...
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#1Shashank Acharya (NU: Northwestern University)H-Index: 2
#2Wenjun Kou (NU: Northwestern University)H-Index: 9
Last. Neelesh A. Patankar (NU: Northwestern University)H-Index: 40
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Balloon dilation catheters are often used to quantify the physiological state of peristaltic activity in tubular organs and comment on their ability to propel fluid which is important for healthy human function. To fully understand this system's behavior, we analyzed the effect of a solitary peristaltic wave on a fluid-filled elastic tube with closed ends. A reduced order model that predicts the resulting tube wall deformations, flow velocities and pressure variations is presented. This simplifi...
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#1Dustin A. Carlson (NU: Northwestern University)H-Index: 23
#2Jacqueline Prescott (NU: Northwestern University)H-Index: 4
Last. John E. Pandolfino (NU: Northwestern University)H-Index: 79
view all 9 authors...
BACKGROUND & AIMS This study aimed to assess the accuracy of functional luminal imaging probe (FLIP) Panometry to detect esophagogastric junction (EGJ) obstruction assigned by high-resolution manometry (HRM) and the Chicago Classification version 4.0 (CCv4.0). METHODS 687 adult patients that completed FLIP and HRM for primary esophageal motility evaluation and 35 asymptomatic volunteers ("controls") were included. EGJ opening was evaluated with 16-cm FLIP during sedated endoscopy via EGJ-distens...
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#1Dustin A. Carlson (NU: Northwestern University)H-Index: 23
#2Alexandra J. Baumann (NU: Northwestern University)H-Index: 5
Last. John E. Pandolfino (NU: Northwestern University)H-Index: 79
view all 10 authors...
Background and aims null This study aimed to systematically evaluate a classification scheme of secondary peristalsis using functional luminal imaging probe (FLIP) panometry through comparison with primary peristalsis on high-resolution manometry (HRM). null Methods null 706 adult patients that completed FLIP and HRM for primary esophageal motility evaluation and 35 asymptomatic volunteers ("controls") were included. Secondary peristalsis, that is, contractile responses (CRs), was classified on ...
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Last. Peter J. Kahrilas (NU: Northwestern University)H-Index: 122
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Background null Proton pump inhibitors (PPIs) are widely used to treat and prevent acid-related disorders. Despite high efficacy, PPI safety has been increasingly scrutinised. However, no comprehensive review summarising investigations of various adverse events is available. null Aims null To perform an umbrella review to comprehensively assess associations between adverse events and PPI use. null Methods null In accordance with PRISMA, an umbrella review of systematic reviews with meta-analyses...
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#2Marcelo F. VelaH-Index: 32
Last. Afrin KamalH-Index: 6
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#1Katharine P. Rooney (NU: Northwestern University)H-Index: 2
#2Alexandra J. Baumann (NU: Northwestern University)H-Index: 5
Last. Dustin A. Carlson (NU: Northwestern University)H-Index: 23
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Achalasia is a disorder of impaired lower esophageal sphincter (LES) relaxation and failed peristalsis traditionally characterized by manometry.1 As impaired LES relaxation is a mechanism of reduced esophagogastric junction (EGJ) opening, abnormally reduced EGJ distensibility assessed with functional luminal imaging probe (FLIP) was reported among patients with untreated achalasia.2-5 Therefore, we aimed to describe the performance characteristics of EGJ opening parameters on FLIP panometry amon...
5 CitationsSource
#1Frank ZerbibH-Index: 52
#1Frank Zerbib (University of Bordeaux)H-Index: 9
Last. C. Prakash Gyawali (WashU: Washington University in St. Louis)H-Index: 29
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Up to 40% of patients with symptoms suspicious of gastroesophageal reflux disease (GERD) do not respond completely to proton pump inhibitor (PPI) therapy. The term "refractory GERD" has been used loosely in the literature. A distinction should be made between refractory symptoms (ie, symptoms may or may not be GERD-related), refractory GERD symptoms (ie, persisting symptoms in patients with proven GERD, regardless of relationship to ongoing reflux), and refractory GERD (ie, objective evidence of...
3 CitationsSource