John E. Pandolfino
Northwestern University
Internal medicineRadiologySurgeryCardiologyPeristalsisGERDEsophagusEndoscopyHigh resolution manometryDiseaseAchalasiaDysphagiaEsophageal motility disorderProton-pump inhibitorEsophageal pressureNuclear medicineEsophagogastric junctionRefluxMedicineGastroenterology
692Publications
79H-index
17.4kCitations
Publications 693
Newest
#1Dustin A. Carlson (NU: Northwestern University)H-Index: 23
#2Alexandra J. Baumann (NU: Northwestern University)H-Index: 5
Last. John E. Pandolfino (NU: Northwestern University)H-Index: 79
view all 9 authors...
INTRODUCTION High-resolution manometry (HRM) is generally considered the primary method to evaluate esophageal motility; functional luminal imaging probe (FLIP) panometry represents a novel method to do so and is completed during sedated endoscopy. This study aimed to compare HRM and FLIP panometry in predicting esophageal retention on timed barium esophagram (TBE). METHODS A total of 329 adult patients who completed FLIP, HRM, and TBE for primary esophageal motility evaluation were included. An...
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#1Alexander H. Xiao (NU: Northwestern University)H-Index: 2
#2Stephen Y. Chang (NU: Northwestern University)H-Index: 2
Last. Rajesh N. Keswani (NU: Northwestern University)H-Index: 32
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COVID-19 has caused a backlog of endoscopic procedures; colonoscopy must now be prioritized to those who would benefit most. We determined the proportion of screening and surveillance colonoscopies appropriate for rescheduling to a future year through strict adoption of US Multi-Society Task Force (USMSTF) guidelines. We conducted a single-center observational study of patients scheduled for “open-access colonoscopy”—ordered by a primary care provider without being seen in gastroenterology clini...
2 CitationsSource
#1Hui Su (Capital Medical University)H-Index: 3
#2Amanda J. Krause (NU: Northwestern University)H-Index: 2
Last. Dustin A. Carlson (NU: Northwestern University)H-Index: 23
view all 10 authors...
Background/Aims Incorporation of complementary and provocative test swallows to the high-resolution manometry (HRM) protocol offers potential to address limitations posed by HRM protocols that involve only a single swallow type. The aim of this study is to describe normal findings of a comprehensive HRM testing protocol performed on healthy asymptomatic volunteers. Methods Thirty healthy asymptomatic volunteers completed HRM with 5-mL liquid swallows in the supine position. They also completed 5...
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#1Rena Yadlapati (UCSD: University of California, San Diego)H-Index: 18
#2John E. Pandolfino (NU: Northwestern University)H-Index: 79
Last. Philip A. Weissbrod (UCSD: University of California, San Diego)H-Index: 10
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The Reflux Band, an external upper esophageal sphincter (UES) compression device, reduces esophago-pharyngeal reflux events. This study aimed to assess device efficacy as an adjunct to proton pump inhibitor (PPI) therapy in patients with laryngopharyngeal reflux (LPR). This two-phase prospective clinical trial enrolled adults with at least 8 weeks of laryngeal symptoms (sore throat, throat clearing, dysphonia) not using PPI therapy at two tertiary care centers over 26 months. Participants used d...
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#1Shashank Acharya (NU: Northwestern University)H-Index: 2
#2Wenjun Kou (NU: Northwestern University)H-Index: 9
Last. Neelesh A. Patankar (NU: Northwestern University)H-Index: 40
view all 7 authors...
Balloon dilation catheters are often used to quantify the physiological state of peristaltic activity in tubular organs and comment on their ability to propel fluid which is important for healthy human function. To fully understand this system's behavior, we analyzed the effect of a solitary peristaltic wave on a fluid-filled elastic tube with closed ends. A reduced order model that predicts the resulting tube wall deformations, flow velocities and pressure variations is presented. This simplifi...
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#1Abraham KhanH-Index: 9
#2Rena Yadlapati (UCSD: University of California, San Diego)H-Index: 18
Last. John E. Pandolfino (NU: Northwestern University)H-Index: 79
view all 8 authors...
The recommended diagnostic criteria for achalasia have been recently updated by Chicago Classification version 4.0 (CCv4.0), the widely accepted classification scheme for esophageal motility disorders using metrics from high-resolution manometry (HRM). CCv4.0 continued upon prior versions by subtyping achalasia into type I, type II, and type III on HRM. The achalasia subgroup of the CCv4.0 Working Group developed both conclusive and inconclusive statements for the HRM diagnoses of achalasia subt...
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#1Dustin A. Carlson (NU: Northwestern University)H-Index: 23
#2Jacqueline Prescott (NU: Northwestern University)H-Index: 4
Last. John E. Pandolfino (NU: Northwestern University)H-Index: 79
view all 9 authors...
BACKGROUND & AIMS This study aimed to assess the accuracy of functional luminal imaging probe (FLIP) Panometry to detect esophagogastric junction (EGJ) obstruction assigned by high-resolution manometry (HRM) and the Chicago Classification version 4.0 (CCv4.0). METHODS 687 adult patients that completed FLIP and HRM for primary esophageal motility evaluation and 35 asymptomatic volunteers ("controls") were included. EGJ opening was evaluated with 16-cm FLIP during sedated endoscopy via EGJ-distens...
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#1Wenjun Kou (NU: Northwestern University)H-Index: 9
#2Dustin A. CarlsonH-Index: 23
Last. John E. PandolfinoH-Index: 79
view all 7 authors...
High-resolution manometry (HRM) is the primary procedure used to diagnose esophageal motility disorders. Its interpretation and classification includes an initial evaluation of swallow-level outcomes and then derivation of a study-level diagnosis based on Chicago Classification (CC), using a tree-like algorithm. This diagnostic approach on motility disordered using HRM was mirrored using a multi-stage modeling framework developed using a combination of various machine learning approaches. Specif...
#1Tiffany Taft (NU: Northwestern University)H-Index: 16
#2Dustin A. Carlson (NU: Northwestern University)H-Index: 23
Last. John E. Pandolfino (NU: Northwestern University)H-Index: 79
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Abstract: null null Background and Aims null Patient symptom reporting often does not correlate with pathophysiological markers of esophageal disease, including eosinophilic esophagitis (EoE). Esophageal hypervigilance and symptom-specific anxiety are emerging as important considerations in understanding symptom reporting. As such, we aimed to conduct the first study of these constructs in EoE. null null null Methods null A retrospective review of an EoE patient registry was conducted and includ...
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#1Dustin A. Carlson (NU: Northwestern University)H-Index: 23
#2Alexandra J. Baumann (NU: Northwestern University)H-Index: 5
Last. John E. Pandolfino (NU: Northwestern University)H-Index: 79
view all 10 authors...
Background and aims null This study aimed to systematically evaluate a classification scheme of secondary peristalsis using functional luminal imaging probe (FLIP) panometry through comparison with primary peristalsis on high-resolution manometry (HRM). null Methods null 706 adult patients that completed FLIP and HRM for primary esophageal motility evaluation and 35 asymptomatic volunteers ("controls") were included. Secondary peristalsis, that is, contractile responses (CRs), was classified on ...
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